Analysis of influencing factors on monohydroxylated derivative of oxcarbazepine plasma concentration in children with epilepsy

Epilepsy is one of the most frequent chronic neurologic disorders that affects nearly 1% of the population worldwide, especially in developing countries. Currently, several antiepileptic drugs (AEDs) are available for its therapy, and although the prognosis is good for most patients, 20%–30% amongst them do not reach seizure freedom. Numerous factors may explain AED-resistance such as sex, age, ethnicity, type of seizure, early epilepsy onset, suboptimal dosing, poor drug compliance, alcohol abuse, and in particular, genetic factors. Specifically, the interindividual differences in drug response can be caused by single nucleotide polymorphisms (SNPs) in genes encoding for drug efflux transporters, for the brain targets of AEDs, and for enzymes involved in drug metabolism. In this review, we used the PubMed database to retrieve studies that assessed the influence of SNPs on the pharmacokinetic (PK), pharmacodynamic (PD), and efficacy of new antiepileptic drugs. Our results showed that polymorphisms in the ABCB1, ABCC2, UGT1A4, UGT2B7, UGT2B15, CYP2C9, and CYP2C19 genes have an influence on the PK and efficacy of AEDs, suggesting that a genetic pre-evaluation of epileptic patients could help clinicians in prescribing a personalized treatment to improve the efficacy and the safety of the therapy.

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Analysis of influencing factors on monohydroxylated derivative of oxcarbazepine plasma concentration in children with epilepsy

Cited by 2 publications

References 52 publications

Pharmacogenetics and Oxcarbazepine in Children and Adolescents: Beyond *HLA-B**15:02

Pharmacogenetics and Oxcarbazepine in Children and Adolescents: Beyond *HLA-B**15:02

Polymorphisms Affecting the Response to Novel Antiepileptic Drugs

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Analysis of influencing factors on monohydroxylated derivative of oxcarbazepine plasma concentration in children with epilepsy

Cited by 2 publications

References 52 publications

Pharmacogenetics and Oxcarbazepine in Children and Adolescents: Beyond HLA-B*15:02

Pharmacogenetics and Oxcarbazepine in Children and Adolescents: Beyond HLA-B*15:02

Polymorphisms Affecting the Response to Novel Antiepileptic Drugs

Contact Info

Product

Resources

About

Pharmacogenetics and Oxcarbazepine in Children and Adolescents: Beyond *HLA-B**15:02

Pharmacogenetics and Oxcarbazepine in Children and Adolescents: Beyond *HLA-B**15:02