Analysis of interleukin-10 gene polymorphisms and hepatitis C susceptibility in Pakistan

Afzal, Muhammad Sohail; Tahir, Sadia; Salman, Amna; Baig, Tahir Ahmed; Shafi, Talha; Zaidi, Najm Us Sahar Sadaf; Qadri, Ishtiaq

doi:10.3855/jidc.1338

Cited by 41 publications

(44 citation statements)

References 29 publications

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“…Two genotype polymorphisms of IL-18 (137/GC and 607/CA) were associated with the outcome of HCV infection in Tunisian patients [20]. The analysis of IL-10 gene polymorphisms indicated a variation between the proinflammatory and anti-inflammatory cytokine responses, which may have resulted in immunodeficiency to HCV infection in Pakistan [21]. Meanwhile, no significant correlation has been found between SNPs of IL-10 and histological activity index in HCV patients [22].…”

Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphisms of interleukins associated with hepatitis C virus infection in Egypt

Khalil

Arfa

El-Masrey

et al. 2017

J Infect Dev Ctries

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Introduction: Hepatitis C is a liver disease caused by the hepatitis C virus (HCV). It can cause both acute and chronic hepatitis infection. Based on secretion of required cytokines upon infection, HCV can improve its own RNA and successfully complete the replication cycle. Importantly, single nucleotide polymorphisms (SNPs) are the most common type of genetic variation and have been found to play a critical role in modulation of cellular cytokine production and interaction. Methodology: A total of 100 blood samples were obtained from HCV patients, and 120 samples were obtained from healthy individuals who served as controls. SNPs of interleukin-10/592 (IL-10/592) and IL-4/589 were investigated for possible connection with HCV infection. Relative expression of IL-4, IL-6, and IL-10 were detected using real-time polymerase chain reaction and enzyme-linked immunosorbent assay Results: The polymorphisms of IL-10 revealed a high rate of mutant genotype CC within the location IL-10/592 in HCV patients and controls, which resulted in low secretion of IL-10. Interestingly, the findings here demonstrate a positive association between HCV load of viremia and the mutant genotype IL-4-589/TT accompanied with low expression IL-4 in comparison with IL-6 expression. Conclusions: These data suggest that the expression of IL-4 is inversely proportional to HCV load of viremia, and this connection is due to the high level of mutant genotype IL-4-589/TT in infected patients located in gene promoter and inhibits gene expression.

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Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphisms of interleukins associated with hepatitis C virus infection in Egypt

Khalil

Arfa

El-Masrey

et al. 2017

J Infect Dev Ctries

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“…Recent meta-analysis further showed no significant association between IL-10-819C/T (MaeIII) and IL-10 -592A/C (RsaI) polymorphisms with chronic HCV infection compared to healthy controls in Caucasian and Oriental populations [29]. By contrast, Afzal et al reported suggestive evidence of an association with hepatitis C for the IL-10 -819C/T (-592C/A) promoter polymorphism at the allele level but not in genotype distribution in a Pakistani population [33].…”

Section: Discussionmentioning

confidence: 92%

Association of interleukin-10 polymorphisms with chronic hepatitis C virus infection in a case-control study and its effect on the response to combined pegylated interferon/ribavirin therapy

et al. 2014

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We conducted a case-control study involving 150 genotype 3 chronic hepatitis C virus (HCV) patients and 150 healthy controls to investigate the association of polymorphisms in the interleukin-10 (IL-10) gene with chronic HCV infection and the association of these polymorphic variants with the combination of pegylated interferon (Peg-IFN) and ribavirin therapy response. Our data revealed that the GG genotype of IL-10 -1082A/G exhibited significant association with genotype 3 chronic HCV infection compared to controls. Treatment response data also showed a significant increase in risk for the GG genotype of IL-10 -1082A/G in response-relapse patients or non-responder patients compared to sustained virological response patients. Further, a significant increase in risk was also revealed for the CC genotype of IL-10 -592A/C in response-relapse patients or non-responder patients compared to sustained virological response patients, suggesting a role of the GG genotype of IL-10 -1082A/G and CC genotype of IL-10 -592A/C in the treatment outcome of combined Peg-IFN/ribavirin therapy.

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“…In previous studies, the CCG haplotype was associated with increased IL-10 production compared with the ATA and CCA haplotypes (Turner et al, 1997). In addition, Afzal et al (2011), showed that there were significant differences between HBV patients and controls in regard to ATG and CCA haplotypes. Haplotype analysis in Japanese and Chinese populations also revealed that IL-10 haplotype ATA was related to the persistent of HBV infection (Miyazoe et al, 2002;Peng et al, 2006).…”

Section: Il-10mentioning

confidence: 89%

Impact of host gene polymorphisms on susceptibility to chronic hepatitis B virus infection

Moudi

Heidari

Mahmoudzadeh‐Sagheb

2016

Infection, Genetics and Evolution

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Analysis of interleukin-10 gene polymorphisms and hepatitis C susceptibility in Pakistan

Abstract: Introduction: Hepatitis C virus (HCV) commonly causes a chronic infection but few of patients are able to clear the virus naturally. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that can suppress the immune response against HCV. Interindividual variations in IL-

Cited by 41 publications

References 29 publications

Single nucleotide polymorphisms of interleukins associated with hepatitis C virus infection in Egypt

Single nucleotide polymorphisms of interleukins associated with hepatitis C virus infection in Egypt

Association of interleukin-10 polymorphisms with chronic hepatitis C virus infection in a case-control study and its effect on the response to combined pegylated interferon/ribavirin therapy

Impact of host gene polymorphisms on susceptibility to chronic hepatitis B virus infection

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