Analysis of iodinated haloacetic acids in drinking water by reversed-phase liquid chromatography/electrospray ionization/tandem mass spectrometry with large volume direct aqueous injection

Li, Yongtao; Whitaker, Joshua S.; McCarty, Christina L.

doi:10.1016/j.chroma.2012.05.005

Cited by 30 publications

(20 citation statements)

References 42 publications

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“…In general, co-existing anions (particularly chloride and sulfate) at high concentrations could interference with the ESI/MS sensitivity if injected directly. The anion concentrations in the water samples collected from P1 (Table S1) were lower than 300 mg/L and sufficient absolute recoveries (89-106%) were obtained for all the iodoacetic acids [24]. In addition, the precursor and product ions of the anions (chlorate, bromate, iodate and perchlorate) in LC-MS/MS [36] are different from those of the HAAs in this study.…”

Section: Occurrence and Concentration Of Haas In Finished Water From mentioning

confidence: 85%

“…Recently they have been analyzed by LC/MS using a modified column (porous graphitic carbon) for retention of MIAA [23]. To improve the sensitivity, large volume direct aqueous injection with LC/ESI/MS/MS was applied for the analysis of four iodo-HAAs (MIAA, CIAA, BIAA, and DIAA) at low concentration (ng/L) in drinking water [24]. Optimization of UPLC/MS methods would be a logical choice for emerging mixed HAAs in disinfected water, and especially for more hydrophilic acidic DBPs.…”

Section: Introductionmentioning

confidence: 99%

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Optimized chromatographic conditions for separation of halogenated acetic acids by ultra-performance liquid chromatography–electrospray ionization-mass spectrometry

Luo

Wang

et al. 2013

Journal of Chromatography A

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a b s t r a c tEmerging halogenated acetic acids (HAAs), especially mixed halogenated acids such as chlorobromo-, chloroiodo-and bromoiodo-acetic acids, are unregulated disinfection by-products in drinking water. Because these compounds are hydrophilic and strongly acidic, they are difficult to detect at trace levels using approved analytical methods. In the present study, 13 HAAs were effectively separated on three ultra-performance liquid chromatography columns. The effects of changing in the aqueous mobile phase, acidic solutions and cationic volatile ion pair reagents were investigated. The samples were pretreated by filtration, and extraction, while derivatization and concentration procedures were not required. The limits of quantitation for regulated HAAs were between 0.5 g/L and 1.7 g/L and for unregulated HAAs were 1.2 and 5.8 g/L, especially for the iodinated acetic acids were 1.5 and 2.1 g/L. The method was applied to two finished water samples collected in China (Shanghai and Xuzhou) from water treatment plants that use chlorine for disinfection. Multiple unregulated HAAs were found in the two samples, but iodoacids were only detected in the water sample from Shanghai, which could be attributed to the characteristics of the source water. The presence of unregulated HAAs, especially mixed bromo-and iodoacetic acids, in the finished water samples could affect human health, and this warrants further investigation.

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Section: Occurrence and Concentration Of Haas In Finished Water From mentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Optimized chromatographic conditions for separation of halogenated acetic acids by ultra-performance liquid chromatography–electrospray ionization-mass spectrometry

Luo

Wang

et al. 2013

Journal of Chromatography A

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“…Among them, we highlight direct aqueous injection (DAI) without any concentration or enrichment steps. It is a technique that has significantly simplified the analytical process by eliminating the need for timeconsuming and labor-intensive sample extraction in water samples (Li et al 2012;Hao et al 2013).…”

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confidence: 99%

Environmentally Relevant Concentrations of Atrazine and Ametrine Induce Micronuclei Formation and Nuclear Abnormalities in Erythrocytes of Fish

Botelho

Monteiro

Christofoletti

et al. 2015

Arch Environ Contam Toxicol

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A rapid and sensitive method using liquid chromatography coupled with mass spectrometry triple quadrupole direct aqueous injection for analysis of atrazine and ametrine herbicides in surface waters was developed. According to the validation method, water samples from six different locations in the Piracicaba River were collected monthly from February 2011 to January 2012 and injected into a liquid chromatographer/dual mass spectrometer without the need for sample extraction. The method was validated and shown to be precise and accurate; limits of detection and quantification were 0.07 and 0.10 µg L(-1) for atrazine and 0.09 and 0.14 µg L(-1) for ametrine. During the sampling period, concentrations of atrazine ranged from 0.11 to 1.92 µg L(-1) and ametrine from 0.25 to 1.44 µg L(-1). After analysis of the herbicides, Danio rerio were exposed a range of concentrations found in the river water to check the induction of micronuclei and nuclear abnormalities (NAs) in erythrocytes. Concentrations of atrazine and ametrine >1.0 and 1.5 µg L(-1), respectively, induced MN formation in D. rerio. Ametrine was shown to be more genotoxic to D. rerio because a greater incidence of NAs was observed compared with atrazine. Therefore, environmentally relevant concentrations of atrazine and ametrine found in the Piracicaba River are dangerous to the aquatic biota.

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“…Researchers have embraced MS for HAAs analysis (Duan et al, 2011;Zhang et al, 2011;Li et al, 2012Li et al, , 2013Prieto-Blanco et al, 2012;Casas Ferreira et al, 2013;Hung and Her, 2013;Luo et al, 2013). Derivatization methods (Li et al, 2013) convert the HAAs to volatile species amenable for GC-MS analysis, similar to USEPA methods (USEPA, 1995(USEPA, , 2003 and others (Hammami and Driss, 2013;Liu et al, 2013), but have high labor costs.…”

Section: Introductionmentioning

confidence: 98%

“…An effort to automate the grab sample derivatization (Casas Ferreira et al, 2013) proved successful, thus minimizing the labor. Tandem MS techniques typically use some form of pretreatment or preconcentration coupled with GC (Li et al, 2013), high pressure liquid chromatography (HPLC) (Li et al, 2012;Prieto-Blanco et al, 2012), ultra pressure LC (UPLC) (Duan et al, 2011;Luo et al, 2013), or capillary electrophoresis (CE) (Zhang et al, 2011;Hung and Her, 2013) to detect and quantify HAAs. Two reports (Duan et al, 2011;Li et al, 2012) and USEPA 557 (USEPA, 2009) use direct aqueous injection and avoid complex pretreatment and preconcentration techniques with excellent results.…”

Section: Introductionmentioning

confidence: 99%

A fully-automated analyzer for determining haloacetic acid concentrations in drinking water

2014

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Analysis of iodinated haloacetic acids in drinking water by reversed-phase liquid chromatography/electrospray ionization/tandem mass spectrometry with large volume direct aqueous injection

Cited by 30 publications

References 42 publications

Optimized chromatographic conditions for separation of halogenated acetic acids by ultra-performance liquid chromatography–electrospray ionization-mass spectrometry

Optimized chromatographic conditions for separation of halogenated acetic acids by ultra-performance liquid chromatography–electrospray ionization-mass spectrometry

Environmentally Relevant Concentrations of Atrazine and Ametrine Induce Micronuclei Formation and Nuclear Abnormalities in Erythrocytes of Fish

A fully-automated analyzer for determining haloacetic acid concentrations in drinking water

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