Using collocated measurements from geostationary and polar-orbital satellites over tropical continents, we provide a large-scale statistical assessment of the relative influence of aerosols and meteorological conditions on the lifetime of mesoscale convective systems (MCSs). Our results show that MCSs' lifetime increases by 3-24 h when vertical wind shear (VWS) and convective available potential energy (CAPE) are moderate to high and ambient aerosol optical depth (AOD) increases by 1 SD (1σ). However, this influence is not as strong as that of CAPE, relative humidity, and VWS, which increase MCSs' lifetime by 3-30 h, 3-27 h, and 3-30 h per 1σ of these variables and explain up to 36%, 45%, and 34%, respectively, of the variance of the MCSs' lifetime. AOD explains up to 24% of the total variance of MCSs' lifetime during the decay phase. This result is physically consistent with that of the variation of the MCSs' ice water content (IWC) with aerosols, which accounts for 35% and 27% of the total variance of the IWC in convective cores and anvil, respectively, during the decay phase. The effect of aerosols on MCSs' lifetime varies between different continents. AOD appears to explain up to 20-22% of the total variance of MCSs' lifetime over equatorial South America compared with 8% over equatorial Africa. Aerosols over the Indian Ocean can explain 20% of total variance of MCSs' lifetime over South Asia because such MCSs form and develop over the ocean. These regional differences of aerosol impacts may be linked to different meteorological conditions. mesoscale convective systems | aerosols | meteorological parameters T he hypothesis that aerosols may delay precipitation and increase cloud lifetime of shallow marine clouds (1) has motivated many researchers to study the aerosol indirect effect on convective clouds; however, the influence of aerosols on enhancing cloud lifetime has remained under debate. Mesoscale convective systems (MCSs) are deep convective clouds that cover several hundred kilometers. Previous studies have shown that aerosols affect deep convection, in particular that aerosols increase the number of smaller size cloud condensation nuclei (CCN) (2), which weaken coagulation and coalescence that form rain droplets, and consequently delay warm rainfall (3, 4). These processes allow more cloud droplets to rise above the freezing level and increase latent heat released due to glaciation (5), resulting in stronger updraft speed, enhanced cloud ice content (6), larger anvil size (5), and higher cloud top height (7). The top of the troposphere warms owing to the aerosol-induced changes in convective anvils (8). Although these aerosol effects have been seen in observations from field campaigns (9, 10), they have been undetectable on large spatial and multiyear scales. Rosenfeld et al. (11) have attributed this lack of detectability on the large scale of aerosol invigoration of convection to its variation with meteorological conditions and to the lack of knowledge of the relative humidity (RH) outside the clo...