Analysis of lignans in Schisandra chinensis fruits, leaves, biomasses from in vitro cultures and food supplements

Determination of lignans and phenolic components of Schisandra chinensis (Turcz.) Baill. using HPLC-ESI-ToF-MS and HPLC-online TEAC: Contribution of individual components to overall antioxidant activity and comparison with traditional antioxidant assays

“…Baill. (Schisandraceae), known as Chinese magnolia-vine is a widely-consumed edible plant providing advantageous nutritional and bioactive properties (Ekiert, Szopa, Ekiert, Krzek, & Dzik, 2013). Its fruits are known to be useful as a tonic, sedative, adaptogenic agent in the treatment of several diseases and symptoms such as chronic coughs, spontaneous sweating, palpitation, and fatigue (Lu & Chen, 2009).…”

“…So far, its most important bioactive constituents are thought to be lignans, derivatives of dibenzo [a,c]cyclooctadiene, especially schisandrol A (schisandrin), schisandrol B (gomisin A), deoxyschisandrin (schisandrin A), and γ-schisandrin (schisandrin B) (Szopa & Ekiert, 2011). These compounds are mainly present not only in the fruit but also in the leaves, shoots, or roots (Ekiert et al, 2013;Szopa & Ekiert, 2011).…”

Assessment of absorption of four lignan constituents of JingNing particles in rat gut using <i>in situ</i> single-pass intestinal perfusion

“…The alcohol extract of Schisandra chinensis fruit is one of the components of traditional Chinese herbal medicines in the JingNing particles used as hepato-protective agents [1,2]. Schisandra chinensis fruit has been used for thousands of years in the management of insomnia, coronary heart disease, skin disorders, depression and menopausal symptoms [3,4].…”

Enzymatic assays and molecular modeling studies ofSchisandra chinensislignans and phenolics from fruit and leaf extracts

“…is a widely consumed edible and medicinal plant providing several health beneficial effects. Its fruits are used as tonic, sedative, adaptogenic, and in the treatment of several diseases such as chronic coughs, spontaneous sweating, palpitations, and fatigue 12,13 . Modern research highlighted that S. chinensis has antitumor 14 , antihepatotoxic and hepatoprotective 15,16 , anti-cancer 17 , neuroprotective 18 , anti-diabetic 19 , and antioxidant 17,20 properties.…”

“…Modern research highlighted that S. chinensis has antitumor 14 , antihepatotoxic and hepatoprotective 15,16 , anti-cancer 17 , neuroprotective 18 , anti-diabetic 19 , and antioxidant 17,20 properties. So far, its most important bioactive compounds are thought to be lignans, derivatives of dibenzocyclooctadiene, especially schisandrin (schisandrol A), schisandrol B, schisandrin A and schisandrin B 12,21 which are mainly present in the fruits. However, besides lignans, recently phenolic compounds and triterpenoids were identified in leaves and stems of S. chinensis showing promising bioactivities 22,23 .…”