This study presents a combination of optimal placement and power system development with the aim of supplying electricity for Nuclear Power Plant after the trip of power plant. Power supply to the internal loads of power plant by the off-site power system is one of the main fields of research in achieving the safety Nuclear Power Plant. One of the main purposes in this article is to introduce a suitable and safe place for the construction and connection of a Nuclear Power Plant to the power system. These locations are identified by the power plants on-site loads and the average of the lowest number of relay protection after the Nuclear Power Plant trip, based on electricity considerations. Along with the optimal placement in this paper, the power system development, including the generation and transmission development in order to provide electricity with higher reliability to the Nuclear Power Plant after the trip is also presented. Monte Carlo and Latin Hypercube Sampling probabilistic methods are proposed for locating the site of a Nuclear Power Plant and algorithms of Genetic and Particle Swarm Optimization for locating and developing power generation and transmission systems. The simulation results are implemented on the IEEE RTS 24-bus system, and finally suitable locations for the construction of the Nuclear Power Plant and the generation and transmission development with the aim of feeding the power plant from the off-site power system and sufficient assurance that the reactor core does not melt after the trip, are determined.