For the 5MW offshore wind turbine blade, the control and discrete equations of the fluid domain and structural domain were established respectively, and the calculation formulas of blade loads and damping coefficient were given. Furthermore, the blade entity modeling was completed by using UG and ANSYS Workbench. Based on it, the numerical calculation of blade vibration characteristics under different wind and rotating speeds was carried out, and the reliability verification was conducted by the wind tunnel test. The results of calculation indicate that the numerical results of the first principal stresses at the blade surface along the span-wise direction are consistent with the results of wind tunnel test, which verifies the reliability of the theory and numerical models. Both the influences of the bidirectional fluid-structure interaction (BFSI) and the rotation effect on the characteristics of blade vibration should be underlined. The increase of wind or rotating speed results in the nonlinear increase of the maximum span-wise displacement of the blade and of the Mises-stresses. Under different wind or rotating speed, the blade's maximum displacement occurs at its tip, its maximum Mises-stresses appear at the relative wingspan of 0.55, and the contribution of rotating speed and average wind speed to the displacement or Mises-stress along the span-wise direction is similar.