Analysis of meconium for cocaine in neonates

Biomarkers for detection of prenatal alcohol exposure: A critical review of fatty acid ethyl esters in meconium

“…Meconium is the first stool passed by the infant usually in the first 72 h after birth, ranging from 20-70 g. Meconium is thought to accumulate in the fetal gut as early as 12 weeks of gestation but most likely begins at around 20 weeks (Browne et al, 1992;Caprara et al, 2007;Lewis et al, 1995;Vaughan and Litt, 1987). However, the size of the stool and the gestational period when meconium begins to be accumulated are not well described.…”

Great Lakes Fish as a Source of Maternal and Fetal Exposure To Chlorinated Hydrocarbons

“…Since meconium is not excreted in utero, it represents an accumulation of compounds to which the fetus has been exposed from week 16 of gestation up to birth. Meconium currently is being used as a very accurate means of determining fetal exposure to drugs such as cocaine (Browne et al, 1992), but never has been used as a monitor for fetal exposure to chlorinated hydrocarbons. It is obtained easily, noninvasive, and represents a cumulative monitor for fetal exposure to chemicals during pregnancy.…”

Fetal Gender and Cocaine Exposure as Determinants of Cord Blood Gamma-Glutamyl Transferase Activity

“…In a randomly selected subpopulation, meconium was collected for analysis of cocaine and cocaine metabolites. 9 Urine samples were collected, when clinically indicated, from mothers and infants for suspicion of illicit drug use. This study was approved by the University of Chicago Hospitals Institutional Review Board.…”

“…Meconium samples were analyzed for cocaine and its metabolites with high-performance liquid chromatography (HPLC), as described by Browne et al 9 Positive results were confirmed with gas chromatography mass spectrophotometry. 9…”