Fetal Gender and Cocaine Exposure as Determinants of Cord Blood Gamma-Glutamyl Transferase Activity

Allen, Katrina J.; Wassef, Samir; Tebbett, Ian R.; Covert, Robert F.; Whitington, Peter F.

doi:10.1038/sj.jp.7210619

Cited by 1 publication

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“…Despite the fact that the increased activity is neither having any known clinical significance nor resulted from any fetal forms of the enzyme besides indicating immaturity [29], the activity of GGT was higher in newborns ( p < 0.0001 , Figure 1c) than in infants. In newborns, GGT activity may reach up to 5–7 times the upper limit of normal for adults [30].…”

Section: Discussionmentioning

confidence: 99%

Robust reference intervals for Liver function test (LFT) analytes in newborns and infants

et al. 2012

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BackgroundReference intervals (RIs) are ranges of upper and lower limits of a given analyte which are used for a laboratory test to determine whether a disease is present or absent or to know if the patient is at risk for future disease states. In Ethiopia, a country with highly diversified population groups and geographical sites, there are no established RIs to metabolic analytes including the liver function test (LFT) analytes for the pediatric population though it has been known that liver function assessment in this population is vital as a result of varied vulnerability to both endogenous and xenobiotic substances.MethodsA cross sectional study was conducted in Tikur Anbessa Specialized Hospital (TASH) and Teklehaymanot Health Center (THC) from November 2010 to April 2011. 117 cord blood (from newborns) and venous blood samples (from infants) were collected and analyzed using HumaStar 300. All pre-analytical, analytical and post-analytical aspects were thoroughly controlled. A robust, CLSI/ IFCC recommended, method was used for the determination of upper and lower end points covering 95% of the reference values of each analyte with respective 90% CIs using MedCalc® software.ResultsCombined RIs for newborns and infants were established for albumin, AST, ALP, direct bilirubin and total bilirubin to be 3.88-5.82 g/dl, 16.1-55.4U/l, 130-831U/l, <0.41 mg/dl and <1.37 mg/dl respectively. But, separated RIs were indicated for ALT and GGT as 1.2-23.1U/l and 6.94-24.8U/l ALT; and 30.6-160.7U/L and 10–28.2U/l GGT for newborns and infants respectively. Some maternal and infantile factors were identified to affect the values of analytes.ConclusionAlmost all analytes were different from previously reported values for other target population of similar age group, kit insert values and adult values. So, interpretation of values of these analytes in newborns and infants of Ethiopian population sounds better to be performed by using such RIs taking the effect of some maternal and infantile factors in to account.

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Section: Discussionmentioning

confidence: 99%

Robust reference intervals for Liver function test (LFT) analytes in newborns and infants

et al. 2012

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Fetal Gender and Cocaine Exposure as Determinants of Cord Blood Gamma-Glutamyl Transferase Activity

Abstract: Our findings demonstrate that the reference range for cord blood GGT activity is wide and appears to be influenced by fetal gender and cocaine exposure.

Cited by 1 publication

References 12 publications

Robust reference intervals for Liver function test (LFT) analytes in newborns and infants

Robust reference intervals for Liver function test (LFT) analytes in newborns and infants

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