2013
DOI: 10.1118/1.4818424
|View full text |Cite
|
Sign up to set email alerts
|

Analysis of metabolic washout of positron emitters produced during carbon ion head and neck radiotherapy

Abstract: On the time scale of an in-beam or in-room measurement only the medium-time washout processes play a remarkable role. A slow component may be neglected if the measurements do not exceed 20 min after the end of the irradiation. The fast component is not observed due to the low relative blood filled volume in the brain.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

3
24
0

Year Published

2015
2015
2023
2023

Publication Types

Select...
5
2
1

Relationship

3
5

Authors

Journals

citations
Cited by 29 publications
(27 citation statements)
references
References 24 publications
3
24
0
Order By: Relevance
“…Treatment) have to be taken into account. The biological washout [18,[32][33][34] (perfusion), that has been deduced from a rabbit model and decay analysis of patient data [18,35] and the physical decay, as well as the distribution itself depend on how long the matter was irradiated, how much time passed until the recording started and how long the recording lasted at all [11].…”
Section: Simulationmentioning
confidence: 99%
“…Treatment) have to be taken into account. The biological washout [18,[32][33][34] (perfusion), that has been deduced from a rabbit model and decay analysis of patient data [18,35] and the physical decay, as well as the distribution itself depend on how long the matter was irradiated, how much time passed until the recording started and how long the recording lasted at all [11].…”
Section: Simulationmentioning
confidence: 99%
“…Since this holds true for all investigated time scenarios, one can assume that there is no physically caused deterioration of the image quality within the first 6 − 7 min after the irradiation. It has to be highlighted that metabolic processes also influence the PET image taken with in-room PET, even though the effect is less pronounced compared to off-line PET [17]. Biologically caused effects could not be considered in these phantom experiments.…”
Section: Discussionmentioning
confidence: 90%
“…In-room PET may also utilize a portable PET scanner [14,15]. Regarding off-line PET the most important limitation is the extensive influence of the patient metabolism [13,16,17]. The chemistry of the created radioactive nuclides is very complex and the metabolic processes depend strongly on the anatomic region and the respective physiology of the patient.…”
Section: Introductionmentioning
confidence: 99%
“…Future applications might also benefit from dedicated instrumentation allowing for in-beam PET imaging at enhanced counting statistics 37 and reduced washout effects. 38 This might also allow for shorter PET scan times and enhance clinical practicability as well as patient comfort with respect to the discussed offline approach, where a 30 min acquisition time is used to collect a sufficiently large number of true coincidences.…”
Section: Discussionmentioning
confidence: 99%