Analysis of micro fracture in human Haversian cortical bone under compression

Jonvaux, Julien; Hoc, Thierry; Budyn, Elisa

doi:10.1002/cnm.2478

Cited by 23 publications

(20 citation statements)

References 66 publications

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“…The generated meshes with a 10 μm resolution were exported into an FEM software [55]. The fresh bone mechanical properties and stress field were identified through a dual experimental and numerical method that followed a top-down approach in order to validate theoretical hypotheses on the multi-scale failure mechanisms [56,57] in 2D and 3D. The local elastic Young's moduli were correlated to the phase mineral content that was correlated to the local grey scale averaged in each osteon [58,59,60,61,62,63].…”

Section: Hierarchical Multiscale Model Of Osteocyte 3d Microenvironmentmentioning

confidence: 99%

“…The Poisson's ratios were determined by microextensometry with a mean value of 0.23 and a standard deviation of 0.04 and were inversely correlated to the phase grey levels [56,57]. The local Poisson ratio of osteon I was therefore calculated as follows:…”

Section: Hierarchical Multiscale Model Of Osteocyte 3d Microenvironmentmentioning

confidence: 99%

“…The cement lines Young's moduli were taken 25% lower than their encapsulated osteons based on nanoindentation measurements observed in the literature and not their grey levels. Cement line Poisson's ratio were taken equal to 0.49 owing to their specific protein composition [56]. Each osteon was considered transverse isotropic and characterized by 5 elastic moduli: E T , E L , υ T , υ TL , G TL .…”

Section: Hierarchical Multiscale Model Of Osteocyte 3d Microenvironmentmentioning

confidence: 99%

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Human Stem Cell Derived Osteocytes in Bone-on-Chip

et al. 2018

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Human mesenchymal stem cells were reseeded in decellularized human bone subject to a controlled mechanical loading to create a bone-on-chip that was cultured for over 26 months. The cell morphology and their secretome were characterized using immunohistochemistry and in situ immunofluorescence under confocal microscopy. The presence of stem cell derived osteocytes was confirmed at 547 days. Different cell populations were identified. Some cells were connected by long processes and formed a network. Comparison of the MSCs in vitro reorganization and calcium response to in situ mechanical stimulation were compared to MLOY4 cells reseeded on human bone. The bone-on-chip produced an ECM of which the strength was nearly a quarter of native bone after 109 days and that contained calcium minerals at 39 days and type I collagen at 256 days. The cytoplasmic calcium concentration variations seemed to adapt to the expected in vivo mechanical load at the successive stages of cell differentiation in agreement with studies using fluid shear flow stimulation. Some degree of bone-like formation over a long period of time with the formation of a newly formed matrix was observed.

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Section: Hierarchical Multiscale Model Of Osteocyte 3d Microenvironmentmentioning

confidence: 99%

Section: Hierarchical Multiscale Model Of Osteocyte 3d Microenvironmentmentioning

confidence: 99%

Section: Hierarchical Multiscale Model Of Osteocyte 3d Microenvironmentmentioning

confidence: 99%

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Human Stem Cell Derived Osteocytes in Bone-on-Chip

et al. 2018

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“…To further extend the study, cracks of different sizes were numerically induced in the bone to gauge the utility of the NBPS (vis‐à‐vis DBPS) in determining the extent of this kind of damage in bones that occurs during accidents. Previously, Jonvaux et al proposed a method that combined customized experimental setting for microcompression tests of millimetric bone specimens and a finite element contact model conforming to the bone morphology that tracked advancing microcracks. In the present study, the size of the crack was varied from 2‐mm spherical crack to 10‐mm spherical crack.…”

Section: Parametric Study Of Bone Degradation Monitoring Using Nbpsmentioning

confidence: 99%

Numerical evaluation of nonbonded piezo sensor for biomedical diagnostics using electromechanical impedance technique

Srivastava

Bhalla

2018

Numer Methods Biomed Eng

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Directly bonded piezo sensor, conventionally employed in the electromechanical impedance (EMI) technique, although a proven candidate for structural health monitoring, is severely constrained in its application in the biomedical field due to its bonding requirement. In contrast, nonbonded piezo sensor (NBPS) provides a viable platform to assess the condition of human bones, tissues, and other biomedical subjects using the EMI technique without inflicting pain or irritation to the skin. The name NBPS was coined to emphasize that there was no direct bonding between the PZT patch and the live subject; instead, the PZT patch was bonded to a supporting medium, which maintains the mechanical interaction between the PZT patch and the subject.However, there are several aspects in the analysis of NBPS configuration that cannot be addressed completely through experimental study due to measurement constraints, cost, and time. For example, experimentally changing the density of bone continuously to study the osteoporosis effect is a tedious task warranting large number of specimens. This paper presents a detailed parametric study based on finite element method covering condition monitoring of human bones using the NBPS configuration. It is for the first time that 3D analysis for specimen identification and damage detection in bones using NBPS has been carried out. In addition to the validation of the numerical model against the previously established experimental studies involving bones, quantification of the extent of damage and its localization has been investigated. The density changes due to osteoporosis in bones are comprehensively investigated by the NBPS including the quantification aspect of osteoporosis/damage. Definite acquisition of bone signature and detection of physiological changes in bones are achieved even with the presence of skin, muscle, and fat layers on the bone.

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“…Beno et al [77] is calculated by using equations (16)(17) [78]. Equation (15) is applied when i and j are 1, 2, 3 or 6…”

Section: Step 6: Laminate With Lrc Lamellaementioning

confidence: 99%

Multiscale approach including microfibril scale to assess elastic constants of cortical bone based on neural network computation and homogenization method

Barkaoui

Chamekh

Merzouki

et al. 2013

Numer Methods Biomed Eng

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SUMMARYThe complexity and heterogeneity of bone tissue require a multiscale modelling to understand its mechanical behaviour and its remodelling mechanisms. In this paper, a novel multiscale hierarchical approach including microfibril scale based on hybrid neural network computation and homogenisation equations was developed to link nanoscopic and macroscopic scales to estimate the elastic properties of human cortical bone. The multiscale model is divided into three main phases: (i) in step 0, the elastic constants of collagen-water and mineral-water composites are calculated by averaging the upper and lower Hill bounds; (ii) in step 1, the elastic properties of the collagen microfibril are computed using a trained neural network simulation. Finite element (FE) calculation is performed at nanoscopic levels to provide a database to train an in-house neural network program; (iii) in steps 2 to 10 from fibril to continuum cortical bone tissue, homogenisation equations are used to perform the computation at the higher scales. The neural network outputs (elastic properties of the microfibril) are used as inputs for the homogenisation computation to determine the properties of mineralised collagen fibril. The mechanical and geometrical properties of bone constituents (mineral, collagen and cross-links) as well as the porosity were taken in consideration. This paper aims to predict analytically the effective elastic constants of cortical bone by modelling its elastic response at these different scales, ranging from the nanostructural to mesostructural levels. Our findings of the lowest scale"s output were well integrated with the other higher levels and serve as inputs for the next higher scale modelling. Good agreement was obtained between our predicted results and literature data.

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Analysis of micro fracture in human Haversian cortical bone under compression

Cited by 23 publications

References 66 publications

Human Stem Cell Derived Osteocytes in Bone-on-Chip

Human Stem Cell Derived Osteocytes in Bone-on-Chip

Numerical evaluation of nonbonded piezo sensor for biomedical diagnostics using electromechanical impedance technique

Multiscale approach including microfibril scale to assess elastic constants of cortical bone based on neural network computation and homogenization method

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