Analysis of mixed type endometrial carcinoma

Duzguner, Soner; Ilgın, Hilal; Taşçı, Tolga; Duzguner, Ipek Nur Balin; Turan, Taner; Boran, Nurettin; Özfuttu, Ahmet; Tulunay, Gökhan

doi:10.4274/tjod.94759

Cited by 2 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the ratio of metastases to the omentum in the group of patients who had an omentectomy was 5.9%. It was 9.1% in our previous study evaluating mixed-type endometrial carcinoma (19). Similarly, the ratio of omental metastasis in endometrial cancer was reported between 2.4% and 8.3% (8)(9)(10)(11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 98%

What is the importance of omental metastasis in patients with endometrial cancer?

Turan

Üreyen

Karalök

et al. 2014

J Turkish German Gynecol Assoc

Self Cite

View full text Add to dashboard Cite

Objective: To identify surgico-pathologic factors, survival, and the factors determining survival in patients with omental metastasis from endometrial cancer. Material and Methods:Patients with endometrial cancer operated on between 1993-2012 in our hospital and who had omental metastases were included. Patients with either uterine sarcoma or synchronous tumors were excluded.Results: Omentectomy was performed in 811 patients with endometrial cancer, and omental metastasis was found in 48 (5.9%) patients.Tumor type was endometrioid cancer in 26 patients. Omental metastasis was macroscopic and microscopic in 60% and 40% of the patients, respectively. Total omentectomy increased the chance of detection of the microscopic metastases. Among the patients with omental metastasis, 68.8% had positive peritoneal cytology, 66.7% had adnexal involvement, 60.5% had metastases in the lymph nodes, 47.9% had cervical involvement, and 29.2% had serosal involvement; 43.8% of these patients had intra-abdominal spread beyond the omentum, adnexa, and peritoneal cytology. Two-year disease-free survival (DFS) was 28.2%, and 2-y overall survival (OS) was 40%. The depth of myometrial invasion, grade, cytology, and status of pelvic lymph nodes affected 2-y DFS, while cervical invasion and cytology affected 2-y OS. Conclusion:Omental metastasis in endometrial cancer means poor prognosis, and two-thirds of these patients are lost at the end of the second year. Although total omentectomy increases the chance of the detection of micrometastases, its effect on survival is controversial. New treatment modalities are necessary in this patient group. (J Turk Ger Gynecol Assoc 2014; 15: 164-72) Key words: Endometrial cancer, omental metastases, survival Received: 03 June, 2014 Accepted: 25 July, 2014 What is the importance of omental metastasis in patients with endometrial cancer? Abstract of patients involving all stage IV patients. Patients without other intra-abdominal metastases and patients with microscopic omental metastases were included in these studies. The reports, except the studies mentioned above, were presented as very small case series or case reports. The patients with omental metastases were not analyzed with regard to surgico-pathologic characteristics and survival, and the factors determining survival have not been identified sufficiently in endometrial cancer. In this study, the determination of surgico-pathologic factors, survival, and the factors determining survival in patients with omental metastases from endometrial cancer is aimed. Material and Methods Study PopulationThe records and pathologic reports of patients with endometrial cancer who were operated in our clinic between 1993 and 2012 were analyzed retrospectively. The patients with omental metastasis were included. Patients with uterine sarcoma, endometrioid carcinoma involving a sarcoma component, or synchronous tumors were excluded. The data related to demographic characteristics, intraoperative findings, debulking status, surgico-pathologic results, pat...

show abstract

Section: Discussionmentioning

confidence: 98%

What is the importance of omental metastasis in patients with endometrial cancer?

Turan

Üreyen

Karalök

et al. 2014

J Turkish German Gynecol Assoc

Self Cite

View full text Add to dashboard Cite

show abstract

“…These rates differ with tumor histopathology and stage. A study evaluating the mixed histologic type was reported omental metastasis rates as 9.1%, whereas it was 18.7% in serous carcinoma [19,20]. In early-stage serous carcinomas, it is only 5.1-9.8% [21,22].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of omental disease and the role of omentectomy in non-endometrioid endometrial cancer

Seyfettinoglu,

Khatib,

Güleç

et al. 2023

Ginekol Pol

View full text Add to dashboard Cite

Objectives: Non-endometrioid endometrial cancers (non-EEC) have different management from endometrioid endometrial cancers. The purpose of this study was to investigate the prognostic significance of omental disease and the role of omentectomy in non-endometrioid endometrial cancer and discuss the current literature with the findings. Material and methods:The study included two hundred-three patients with non-EEC who underwent surgical treatment and follow-up between January 1996 and December 2018 in a University Hospital Gynecologic Oncology Center. The patients were divided into three groups according to whether omentectomy was performed and the presence of omental metastasis. The patient's demographics, clinical characteristics such as stage, grade, histopathologic type, lymphovascular space invasion (LVSI), myometrial invasion, lymph node involvement, and survival outcomes were compared between the groups. Results:The study included 203 patients. Twenty-five patients (12%) had omental metastases. LVSI was reported in 57.3%, 88.0%, and 43.2% of the non-omentectomy, no-omental metastasis, and omental metastatic groups, respectively (p = 0.001). The 5-year disease-free survival (DFS) and overall survival (OS) rates according to the tumor grade, peritoneal cytology, and lymphadenectomy were also compared and were found to be statistically similar. The five-year OS rates were 70.6% for the group without omental metastases and 16.2% for the group with omental metastases, respectively (p = 0.001). In the group of omentectomy, the five-year DFS rates were 62.2% in cases without omental metastasis and 13.0% in cases with omental metastasis (p = 0.001). The five-year OS rates of 86.3% and DFS rates of 80.0% in the group without omentectomy. Conclusions:In non-endometrioid tumors, the survival rate was better in the group that did not undergo omentectomy. Based on these results, we can say that omentectomy may not be necessary for non-endometrioid tumors whose omentum is found to be normal in intraoperative visual examination.

show abstract

Analysis of mixed type endometrial carcinoma

Cited by 2 publications

References 4 publications

What is the importance of omental metastasis in patients with endometrial cancer?

What is the importance of omental metastasis in patients with endometrial cancer?

Prognostic significance of omental disease and the role of omentectomy in non-endometrioid endometrial cancer

Contact Info

Product

Resources

About