Analysis of MMP-3 polymorphism in osseointegrated implant failure

Munhoz, Francielle Boçon de Araujo; Nogara, Paula Regina Bach; Costa, Francisco Rafael da Costa; Branco, Filipe; Santos, Maria Cristina Leme Godoy dos

doi:10.20396/bjos.v15i4.8650045

Cited by 4 publications

(7 citation statements)

References 20 publications

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“…The literature supports the evidence that SNPs play an important role in the transcription of these inflammatory mediators and may influence the osseointegration success, including single‐nucleotide polymorphism (SNPs) in MMPs …”

Section: Discussionmentioning

confidence: 57%

“…20 Moreover, an intense inflammatory process is mediated by cytokines that point to different cell types and stimulating the production of prostaglandins and MMPs, which are associated with bone and connective tissue breakdown. 21 The literature supports the evidence that SNPs play an important role in the transcription of these inflammatory mediators and may influence the osseointegration success, [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] including singlenucleotide polymorphism (SNPs) in MMPs. [8][9][10] An important point to validate the association between polymorphism and pathological processes is a methodological and study design restricted.…”

Section: Discussionmentioning

confidence: 79%

“…Some single‐nucleotide polymorphism (SNPs) may affect gene expression levels and protein production or functions; consequently, they influence osteogenesis and inflammatory responses. Some SNPs in cytokines and lipid mediators genes were associated with implant loss and peri‐implantitis, explain some of interindividual risk factors …”

Section: Introductionmentioning

confidence: 99%

“…-St. Lituania, UE) overnight. The total amount of aliquot of the digest was electrophoresed on a 2% agarose gel at 20 mA and stained by GelRed Nucleic Acid Stain (Biotium, Inc. Fremont, California).Part of the samples (30% of samples) was genotype in the previous studies of our research group [8][9][10]18.…”

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confidence: 99%

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Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case‐control study

Munhoz

Branco²,

Souza

et al. 2018

Clin Implant Dent Rel Res

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Background Dental implants consist in the treatment of choice to replace tooth loss. The knowledge that implant loss tends to cluster in subsets of individuals may indicate that host response is influenced by genetic factors. Matrix metalloproteinases (MMPs) are enzymes that contribute to degradation and removal of collagen from extracellular matrix. Purpose This case‐control study aimed to investigate the haplotypic combination of MMP polymorphism (rs1144393, rs1799750, rs3025058, and rs11225395) and implant loss. Materials and Methods Two hundred nonsmokers subjects were matched by gender, age, implant number and position and divided in control group, 100 patients with one or more healthy implants, and test group, and 100 patients with one or more implant failures. Genomic DNA was extracted from saliva and genotypes were obtained by PCR‐RFLP. Results A significant association of rs1799750 (MMP‐1) and rs11225395 (MMP‐8) polymorphism on early implant loss was demonstrated (P ≤ 0.001). Global haplotype analysis indicated a significant difference between both groups (P < 0.0001). Haplotype T‐A‐GG‐5A‐C had a statistically significant risk effect, while haplotype C‐A‐G‐6A‐C andT‐G‐2G‐5A‐C had a protective effect in implant loss. Conclusions The results of this study showed that MMPs haplotype are a risk factor to early implant loss.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case‐control study

Munhoz

Branco²,

Souza

et al. 2018

Clin Implant Dent Rel Res

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“…Rogers et al did not specify the minimum implant survival duration. All of the remaining papers chose patients whose implants survived 1 year or longer 11–13,24,25. These studies also varied in how they designed their case-control study.…”

Section: Resultsmentioning

confidence: 99%

<p>The relationship between single nucleotide polymorphisms and dental implant loss: a scoping review</p>

Zhang

Finkelstein²

2019

CCIDE

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Objectives The purpose of this review was to evaluate the relationship between genetic polymorphisms and dental implant loss. Materials and methods All case-control studies examining single nucleotide polymorphisms (SNPs) and dental implant failure were considered. A Boolean search was conducted on PubMed and Scopus to find eligible studies. Results The initial search produced 78 results. Twenty-one studies were considered for inclusion after review and 16 were included in the final review. Twenty-two different polymorphisms were analyzed and statistically significant correlation was found for IL-4, IL-1A, IL-1B, MMP-8, and MMP-1 polymorphisms for dental implant failure. Discussion A limited number of comprehensive studies have been done in this field. Additional studies with larger sample sizes and different ethnic backgrounds need to be done to see if the results can be reproduced. Of the polymorphisms studied, the IL-4 (+33), MMP-8 (−799), MMP-1 (−519), and MMP-1 (−1607) polymorphisms show the greatest association with dental implant loss.

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Profiling Pro‐Inflammatory Proteases as Biomolecular Signatures of Material‐Induced Subcutaneous Host Response in Immuno‐Competent Mice

Tran,

Truong,

Nguyen

et al. 2024

Advanced Science

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Proteases are important modulators of inflammation, but they remain understudied in material‐induced immune response, which is critical to clinical success of biomedical implants. Herein, molecular expression and proteolytic activity of three distinct proteases, namely neutrophil elastase, matrix metalloproteinases, cysteine cathepsins (cathepsin‐K and cathepsin‐B) are comprehensively profiled, in the subcutaneous host response of immuno‐competent mice against different biomaterial implants. Quantitative non‐invasive monitoring with activatable fluorescent probes reveals that different microparticulate materials induce distinct levels of protease activity with degradable poly(lactic‐co‐glycolic) acid inducing the strongest signal compared to nondegradable materials such as polystyrene and silica oxide. Furthermore, protein expression of selected proteases, attributable to both their inactive and active forms, notably deviates from their activities associated only with their active forms. Protease activity exhibits positive correlations with protein expression of pro‐inflammatory cytokines tumor necrosis factor α and interleukin 6 but negative correlation with pro‐fibrotic cytokine transforming growth factor β1. This study also demonstrates the predictive utility of protease activity as a non‐invasive, pro‐inflammatory parameter for evaluation of the anti‐inflammatory effects of model bioactive compounds on material‐induced host response. Overall, the findings provide new insights into protease presence in material‐induced immune responses, facilitating future biomaterial assessment to evoke appropriate host responses for implant applications.

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Analysis of MMP-3 polymorphism in osseointegrated implant failure

Cited by 4 publications

References 20 publications

Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case‐control study

Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case‐control study

<p>The relationship between single nucleotide polymorphisms and dental implant loss: a scoping review</p>

Profiling Pro‐Inflammatory Proteases as Biomolecular Signatures of Material‐Induced Subcutaneous Host Response in Immuno‐Competent Mice

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