Analysis of MUC4 expression in the prostatic adenocarcinoma and its pathological implications

Sundaram, Sandhya; Raj, Chanchal; Krishnakumar, R.; Santhosh, D.; Narashiman, Sangeetha; Prathiba, D

doi:10.18203/2320-6012.ijrms20162955

Cited by 1 publication

(2 citation statements)

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“…So, there is an urgent need for more effective and lasting treatment for PCa. MUC4 is one member of the mucin family that have a significant role in tumor growth, intracellular and extracellular signaling, tumor-stromal interactions, metastasis, immunity-and chemotherapeutic agent-resistance (5). The current study determined MUC4 expression in BPH, PIN and prostatic adenocarcinoma.…”

Section: Immunohistochemical Resultsmentioning

confidence: 90%

“…Mucins have the ability to control a number of cellular processes such as growth, differentiation, transformation, invasion, adhesion and immune surveillance. However, the mucin molecule itself becomes changed during progression in cancer cells (5) . Studies have revealed that MUC4 is a transmembrane mucin and epithelial cells in variable tissues expressed it.…”

Section: Introductionmentioning

confidence: 99%

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The Significance of Expression of MUC 4 and IMP-3 in Benign Prostatic Hyperplasia, High Grade Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma(immunohistochemical study)

Elshawarby,

El Attar,

shalan

2023

Benha Medical Journal

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Background: Prostate cancer is one of the most frequent malignancies worldwide. Mucin 4(MUC4) is a transmembrane mucin that is contributed in cell signaling events that guide the proliferation of cells. Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been linked to tumorgenesis and progression of many cancers. Aim: This study aimed to evaluate MUC4 and IMP-3 expression in different prostatic lesions and to relate the results with clinicopathological data. Material and method: This retrospective study examined 40 cases including 10 cases of benign prostatic hyperplasia (BPH), 6 cases of high-grade prostatic intraepithelial neoplasia (HGPIN) and 24 cases of prostatic adenocarcinoma (PCa) . MUC 4 and IMP-3 were used for immunohistochemistry. Results: MUC4 was detected in (100%) of BPH & HGPIN cases and (16.6%) of prostatic carcinoma. IMP3 expressed in (100%) of prostatic cancer cases and expressed in(10%) &(16.7%) of &HGPIN respectively. A significant statistical correlation between IMP3expression and stage, Gleason's grade, pre OP serum PSA level>10ng/ml, --capsular and perineural invasion(P<.001). Conclusion: MUC4 down regulation may be important in identifying the molecular underpinnings of PC. Association between IMP3 over expression and poor prognosis suggesting that PC patients may benefit from a targeted anti-IMP3 therapy.

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Section: Immunohistochemical Resultsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%