Analysis of newly detected leprosy in Sohag Governorate, Upper Egypt, 2004–2008

El-Dawela, Reham Ezz; Mohamed, Abeer M; Yousef, Fouad

doi:10.47276/lr.83.1.71

Cited by 9 publications

(3 citation statements)

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“…2,5,[10][11][12][13][22][23][24][25][26][27][28][29][30]32,35,[37][38][39][40][41]43,44 World Health Organization leprosy classification data were obtained from 28 studies including 39 192 patients. 2,5,10,11,13,22,23,[25][26][27][28][30][31][32][33][34][35][36][37][38][39][41][42][43][44][45][46][47] Paucibacillary leprosy was more frequent than MB leprosy (25 9...…”

Section: Resultsmentioning

confidence: 99%

“…2,5,10,11,13,22,23,[25][26][27][28][30][31][32][33][34][35][36][37][38][39][41][42][43][44][45][46][47] Paucibacillary leprosy was more frequent than MB leprosy (25 954 [66.2%] vs 13 238 [33.8%], respectively), but patients with MB leprosy were 4-fold more likely to have physical disabilities (pooled OR, 4.32; 95% CI, 3.37-5.53; I 2 , 88.9%, P < .001) independent of the study location (Figure 2 and eFigure 3 in the Supplement). 2,5,10,11,22,23,25,27,28,[30][31][32][33][34][35][36][38][39][40][41][42]…”

Section: Resultsmentioning

confidence: 99%

“…World Health Organization leprosy classification data were obtained from 28 studies including 39 192 patients . Paucibacillary leprosy was more frequent than MB leprosy (25 954 [66.2%] vs 13 238 [33.8%], respectively), but patients with MB leprosy were 4-fold more likely to have physical disabilities (pooled OR, 4.32; 95% CI, 3.37-5.53; I 2 , 88.9%, P < .001) independent of the study location (Figure 2 and eFigure 3 in the Supplement).…”

Section: Resultsmentioning

confidence: 99%

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Risk Factors for Physical Disability in Patients With Leprosy

et al. 2019

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(WHO) 2016-2020 Global Leprosy Strategy aims to reinvigorate efforts to control leprosy and avert leprosy disability to less than 1 per million population. OBJECTIVE To systematically identify clinical factors associated with physical disability in patients with leprosy. DATA SOURCE Searches were conducted in Scopus, PubMed, and Web of Science databases to identify studies published from January 23, 1988, to May 23, 2018, using the keywords leprosy and physical disability and related terms. STUDY SELECTION Studies that evaluated patients using the WHO leprosy disability grading system and reported the number of patients with and without disability by clinical characteristics were included. DATA EXTRACTION AND SYNTHESIS The odds ratio (OR) was used as a measure of association between the clinical features and physical disability. Summary estimates were calculated using random-effects models. MAIN OUTCOMES AND MEASURES The primary outcome was physical disability according to the WHO disability classification. The association between clinical features and physical disability was evaluated. RESULTS The search identified 2447 reports. After screening titles and abstracts, 177 full-text articles were assessed for eligibility, and 32 studies were included in the systematic review; 24 of the 32 studies included sex information (39 571 patients), of whom 24 218 (61.2%) were male. Male patients with leprosy were more likely to have physical disability than female patients with leprosy (pooled OR, 1.66; 95% CI, 1.43-1.93; I 2 , 81.3%; P < .001). Persons with multibacillary leprosy were 4-fold more likely to have physical disability than those with paucibacillary leprosy (pooled OR, 4.32; 95% CI, 3.37-5.53; I 2 , 88.9%, P < .001). Patients having leprosy reactions were more likely to have disability (pooled OR, 2.43; 95% CI, 1.35-4.36; I 2 , 92.1%; P < .001). Patients with lepromatous leprosy experienced 5-to 12-fold higher odds of disability. CONCLUSIONS AND RELEVANCE This systematic review and meta-analysis confirms the association between the presence of physical disabilities and male sex, multibacillary leprosy, leprosy reactions, and lepromatous presentation. These findings can guide the development of targeted interventions for early identification of individuals at greater risk of developing physical disabilities and education campaigns to promote early consultation to institute treatment for leprosy reactions and prevent physical disability.

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