Analysis of non-benzodiazepinic anxiolytic agents by capillary zone electrophoresis

Quaglia, M.G.; Farina, A.; Bossù, E.; Dell'Aquila, Caterina

doi:10.1016/0731-7085(95)01340-q

Cited by 10 publications

(3 citation statements)

References 11 publications

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“…Buspirone hydrochloride -8-[4-(4-Pyrimidin-2-ylpiperazin-l-yl)butyl]-8-azaspiro [4,5]decane-7,9-dione hydrochloride CAS-33386-08-2 -is an azaspirodecanedione (BusCl). 1 Buspirone hydrochloride has dopaminergic, noradrenergic, and serotonin-modulating properties and its anxiolytic effects appear to be related to its action on serotonin (5-hydroxytryptamine; 5-HT) neurotransmission.…”

Section: Introductionmentioning

confidence: 99%

“…Buspirone has been shown to be as effective as benzodiazepine in the short-treatment of generalized anxiety disorders and to be less likely to cause sedation or psychomotor and cognitive impairment. It has been determined using a different number of techniques including spectrophotometry, 2 GC, 3,4 capillary zone electrophoresis, 5 voltammetry, 6 HPLC, 7,8 TLC, 9 LC, 10 LC-MS, 11,12 capillary gas chromatography, 13 colorimeric, 14 GC-MS 15 and differential pulse polarography. 16 Although there is an increasing demand for chemical surveillance in the environmental, medical and many other industries, which has created the need for highly sensitive, selective, precise and inexpensive techniques, no ion-selective electrode (ISE) has been constructed for the determination of Buspirone.…”

Section: Introductionmentioning

confidence: 99%

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Flow Injection Analysis with Tubular Membrane Ion‐Selective Electrode and Coated Wires for Buspirone Hydrochloride

et al. 2006

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Summary -New Plastic membrane ion-selective electrode for buspirone hydrochloride based on buspironium tetraphenylborate was prepared. The electrode exhibited mean slope of calibration graph of 58.4 mV per decade of BusCl concentration at 25°C. The electrode can be used within the concentration range 6.3 x10 -5 -10 -2 M BusCl at a pH range of 2.5-7.0. The standard electrode potentials were determined at different temperatures and used to calculate the isothermal temperature coefficient of the electrode, amounting to 0.00056 V°C -1 . The electrode showed a very good selectivity for BusCl with respect to a number of inorganic cations, sugars and amino acids. The electrode was applied to the potentiometric determination of the buspirone ion and its pharmaceutical preparation under batch and flow injection conditions. Also, buspirone was determined by conductimetric titrations. Graphite rod, copper and silver coated wire electrodes were prepared and characterized as sensors for the drug under investigation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Flow Injection Analysis with Tubular Membrane Ion‐Selective Electrode and Coated Wires for Buspirone Hydrochloride

et al. 2006

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“…Several analytical methods have been applied to determine Buspirone hydrochloride (Bu-HCl) quantitatively in their dosage forms including spectrophotometric method [2][3][4][5], liquid chromatography mass spectrometry LC/MS [6][7][8][9], High Performance Liquid Chromatogrphy HPLC [10][11][12][13][14][15][16][17][18], gas chromatography [19] gas chromatography mass spectrometry GCMS [20][21][22], ion selective electrode [20][21][22][23] and potentiometry [24][25][26].…”

Section: Buspirone Hydrochloride 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]mentioning

confidence: 99%

Analytical Determination of Buspirone Hydrochloride in Pure Solutions, Pharmaceutical Preparation and Urine Samples

Rizk¹

2015

Pharm Anal Acta

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Spectroscopic study of the reaction mechanism of buspirone interaction with iodine and tetracyanoethylene reagents and its applications

Zayed

El-Habeeb

2009

Drug Testing and Analysis

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The reactions between the drug buspirone (busp) in its base form and iodine amphoteric reagent (n-donor and/or sigma-acceptor) and with tetracyanoethylene as a pi-acceptor reagent (TCNE) have been studied spectrophotometrically at different reactant concentrations, time intervals, temperatures, and with different solvents and wavelengths, with the aim of selecting the conditions that give the most suitable molar extinction coefficients. This study aims chiefly to throw light on the nature of these reactions and to select the most proper conditions for spectrophotometric application of these reagents to determine this biologically active drug used in treating different diseases. The reaction mechanism involves the formation of busp-I(2) outer and inner sphere complexes. The separated busp-I(2) solid product obtained was investigated using elemental analyses, FT-IR, thermal analyses (TA) and electron ionization mass spectrometry (EI-MS) and was found to be biologically active. The reaction mechanism of busp-TCNE involves the formation of a charge transfer (CT) complex. The analytical parameters of the proposed spectrophotometric procedures were calculated. These procedures were applied in the analysis of busp in its formulations as a drug used to treat psychiatric illnesses. The values of the Sandell sensitivity, standard deviation (SD), relative standard deviation (RSD) and recovery percentage show the high sensitivity of these procedures. This study also presents a promising new busp-I(2) drug derivative that can be used more efficiently for the same purposes as its parent. It gives a clear idea about the possible metabolites and metabolic pathways of busp and its derivative that may occur in vivo.

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Analysis of non-benzodiazepinic anxiolytic agents by capillary zone electrophoresis

Cited by 10 publications

References 11 publications

Flow Injection Analysis with Tubular Membrane Ion‐Selective Electrode and Coated Wires for Buspirone Hydrochloride

Flow Injection Analysis with Tubular Membrane Ion‐Selective Electrode and Coated Wires for Buspirone Hydrochloride

Analytical Determination of Buspirone Hydrochloride in Pure Solutions, Pharmaceutical Preparation and Urine Samples

Spectroscopic study of the reaction mechanism of buspirone interaction with iodine and tetracyanoethylene reagents and its applications

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