Analysis of omeprazole and its main metabolites by liquid chromatography using hybrid micellar mobile phases

Rambla-Alegre, Maria; Esteve‐Romero, Josep; Carda‐Broch, Samuel

doi:10.1016/j.aca.2008.11.059

Cited by 28 publications

(8 citation statements)

References 35 publications

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“…Some methods have been reported to simultaneously determine OPZ, OH-OPZ, and OPZ-SFN in human plasma (Rezk et al, 2006;Rambla-Alegre et al, 2009). However, the nonstereospecific LC-MS/MS method adopted in this article has not been reported previously.…”

Section: Discussionmentioning

confidence: 88%

Relative bioavailability and pharmacokinetic comparison of two different enteric formulations of omeprazole

Liu

Shentu

et al. 2012

J. Zhejiang Univ. Sci. B

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Abstract:In order to comply with the requirements for a drug listed in China, the study was developed to compare the pharmacokinetics and relative bioavailability of two different enteric formulations of omeprazole (OPZ) in healthy Chinese subjects. A total of 32 volunteers participated in the study. Plasma concentrations were analyzed by nonstereospecific liquid chromatography/tandem mass spectrometric (LC-MS/MS) method. After administration of a single 40-mg dose of the two OPZ formulations, the comparative bioavailability was assessed by calculating individual AUC 0-t (the area under the concentration-time curve from time zero to the last measurable concentration), AUC 0-∞ (the area under the concentration-time curve extrapolated to infinity), C max (the maximum observed concentration), and T peak (the time to C max ) values of OPZ, 5-hydroxyomeprazole (OH-OPZ), and omeprazole sulfone (OPZ-SFN), respectively. The 90% confidence intervals (CIs) of AUC 0-t , AUC 0-∞ , and C max were 85

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Section: Discussionmentioning

confidence: 88%

Relative bioavailability and pharmacokinetic comparison of two different enteric formulations of omeprazole

Liu

Shentu

et al. 2012

J. Zhejiang Univ. Sci. B

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“…Therefore, determining of these drugs in pharmaceutical formulations and biological samples is very important. Many analytical methods, such as highperformance liquid chromatography (HPLC) [5][6][7][8][9][10][11][12], microdialysis and HPLC [13], HPLC-mass spectrometry [14], HPLC-tandem mass spectrometry [15], HPLC with coulometric detection [16], liquid chromatography-electrospray quadrupole liner ion trap mass spectrometry [17], solid phase extraction and micellar electrokinetic capillary chromatography [18], liquid chromatography with liquidliquid extraction [19], UV-visible spectrophotometry [20][21][22], and derivative spectroscopy [23,24], have been used for quantitative determination of pantoperazole and omoprazole in drug formulations, plasma, and other biological fluids. Although the chromatographic methods have sufficient sensitivity for determination of OMZ and PNZ in pharmaceutical dosage forms and in biological fluids, they require sample pretreatment and time-consuming extraction steps prior to assay of the drugs.…”

Section: Introductionmentioning

confidence: 99%

Sensitive amperometric detection of omeprazole and pantoperazole at electrodeposited nickel oxide nanoparticles modified glassy carbon electrode

Salimi

Enferadi

Noorbakhash

et al. 2011

J Solid State Electrochem

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Glassy carbon electrode modified with electrodeposited nickel oxide nanoparticles (NiOxNPs) was used as electrocatalyst for oxidation of omeprazole and pentoperazole in alkaline solution. The modified electrode exhibited efficient electrocatalytic activity for the oxidation of omeprazole and pentoperazole with relatively high sensitivity, excellent stability, and long lifetime. Hydrodynamic amperometric method is used for determination of selected analytes. Under optimized condition, the linear concentration range, detection limit, and sensitivity of modified electrode toward omeprazole detection are 4.5-120 μM, 0.4 μM (at signal to noise 3), and 40.1 nA μM −1 cm −2 , respectively. For pantoperazole, hydrodynamic amperometric determination yielded calibration curve with linear range of 2.5-180 μM, detection limit of 0.2 μM, and sensitivity of 39.2 nA μM −1 cm −2 , respectively. The proposed method was successfully applied to pentoperazole and omeprazole determination in drug samples.

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“…MLC allows the analysis of complex matrices, usually without the aid of extraction [23,24] because micelles tend to bind proteins competitively, thereby releasing protein-bound drugs and proteins, thus considerably reducing the cost and analysis time. Proteins are solubilised in micellar media and washed harmlessly away to elute with the solvent front rather than precipitating into the column In addition, MLC has proved to be a useful technique in urine analyses [25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Validation of a MLC method with fluorescence detection for the determination of quinolones in urine samples by direct injection

Rambla-Alegre

Esteve‐Romero

Carda‐Broch

2009

Journal of Chromatography B

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Analysis of omeprazole and its main metabolites by liquid chromatography using hybrid micellar mobile phases

Cited by 28 publications

References 35 publications

Relative bioavailability and pharmacokinetic comparison of two different enteric formulations of omeprazole

Relative bioavailability and pharmacokinetic comparison of two different enteric formulations of omeprazole

Sensitive amperometric detection of omeprazole and pantoperazole at electrodeposited nickel oxide nanoparticles modified glassy carbon electrode

Validation of a MLC method with fluorescence detection for the determination of quinolones in urine samples by direct injection

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