Analysis of other phenolics (capsaicin, gingerol, and alkylresorcinols)

Shah, Ismail; Shah, Muhammad Ajmal; Nawaz, Muhammad Asif; Pervez, Sidra; Noreen, Nida; Vargas-De-La-Cruz, Celia; Khan, Fazlullah; Blundell, Renald; Briffa, Jessica; Azzopardi, Joseph; Niaz, Kamal

doi:10.1016/b978-0-12-816455-6.00006-8

Cited by 8 publications

(8 citation statements)

References 76 publications

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“…However, adding detergent or ethanol can increase its effectiveness and eliminate 99.9% of the HCoV-229E within 5 min. Similarly, chemicals made from phenolics need other helpers to be effective (Shah et al 2020).…”

Section: Phenolicsmentioning

confidence: 99%

Environmental concern regarding the effect of humidity and temperature on 2019-nCoV survival: fact or fiction

Harmooshi

Shirbandi

Rahim

2020

Environ Sci Pollut Res

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The new coronavirus, called 2019-nCoV, is a new type of virus that was first identified in Wuhan, China, in December 2019. Environmental conditions necessary for survival and spread of 2019-nCoV are somewhat transparent but unlike animal coronaviruses. We are poorly aware of their survival in environment and precise factors of their transmission. Countries located in east and west of globe did not have a significant impact on prevalence of disease among communities, and on the other hand, north and south have provided a model for relative prediction of disease outbreaks. The 2019-nCoV can survive for up to 9 days at 25°C, and if this temperature rises to 30°C, its lifespan will be shorter. The 2019-nCoV is sensitive to humidity, and lifespan of viruses in 50% humidity is longer than that of 30%. Also, temperature and humidity are important factors influencing the COVID-19 mortality rate and may facilitate 2019-nCoV transmission. Thus, considering the available and recent evidence, it seems that low temperatures, as well as dry and unventilated air, may affect stability and transmissibility of 2019-nCoV.

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Section: Phenolicsmentioning

confidence: 99%

Environmental concern regarding the effect of humidity and temperature on 2019-nCoV survival: fact or fiction

Harmooshi

Shirbandi

Rahim

2020

Environ Sci Pollut Res

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“…After isolation, the structures of compounds 1-7 were elucidated by diagnostic scrutiny of nuclear magnetic resonance (NMR) and MS data. Compounds were therefore identified, and their 13 C NMR data were identical to those reported for the known metabolites (-)-cytisine (1) [61], alpinumisoflavone (2) [62], (+)-aphylline (3) [63], (-)-anagyrine (4) [64], (-)-N-methylcytisine (5) [65], wighteone (6) [66], and (+)-5,6-dehydrolupanine (7) [67]. The structures of 1-7 are presented in Figure 3.…”

Section: Isolation and Identification Of Opls-recognized Anti-prolife...mentioning

confidence: 99%

“…Gm10 extract yielded compounds 1, 3, and 4, and Gm9 extract afforded compounds 2, 5, 6, and 7. Structures of isolated compounds were elucidated by 1 H and 13 C NMR, through the attached proton test (APT), on an Avance 400 spectrometer (Bruker, Billerica, MA, USA) using CDCl 3 as solvent (400 Mz 1 H; 100 MHz 13 C). All shifts are given in δ (ppm) using tetramethylsilane (TMS) as the internal standard.…”

Section: Purification and Identification Of Anti-proliferatives 1-7 B...mentioning

confidence: 99%

“…Due to these features, this plant can also cause considerable damage and alterations to ecosystems into which it is introduced and, consequently, it is classified as an invasive plant [8,11]. Various strategies have been pursued to handle and control G. monspessulana invasion, and therefore, several studies have been developed to study its ecological relationships [12,13] and even its biomass exploitation [7,14,15].…”

Section: Introductionmentioning

confidence: 99%

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Identification of Anti-Proliferative Compounds from Genista monspessulana Seeds through Covariate-Based Integration of Chemical Fingerprints and Bioactivity Datasets

2022

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Genista monspessulana (L.) L.A.S. Johnson (Fabaceae) is a Mediterranean plant introduced to South America and other regions for ornamental purposes. However, it is considered an invasive shrub due to its reproductive vigor in many areas. Unlike other Genista plants, G. monspessulana has few studies disclosing its biologically active components, particularly cytotoxic agents against cancer cells. Thus, as part of our research on anti-proliferative bioactives, a set of ethanolic seed extracts from ten accessions of G. monspessulana, collected in the Bogotá plateau, were evaluated against four cell lines: PC-3 (prostate adenocarcinoma), SiHa (cervical carcinoma), A549 (lung carcinoma), and L929 (normal mouse fibroblasts). Extracts were also analyzed through liquid chromatography coupled with mass spectrometry (LC/MS) to record chemical fingerprints and determine the composition and metabolite variability between accessions. Using multiple covariate statistics, chemical and bioactivity datasets were integrated to recognize patterns and identify bioactive compounds among studied extracts. G. monspessulana seed-derived extracts exhibited dose-dependent antiproliferative activity on PC-3 and SiHa cell lines (>500 µg/mL < IC50 < 26.3 µg/mL). Seven compounds (1–7) were inferred as the compounds most likely responsible for the observed anti-proliferative activity and subsequently isolated and identified by spectroscopic techniques. A tricyclic quinolizidine (1) and a pyranoisoflavone (2) were found to be the most active compounds, exhibiting selectivity against PC-3 cell lines (IC50 < 18.6 µM). These compounds were used as precursors to obtain a quinolizidine-pyranoisoflavone adduct via Betti reaction, improving the activity against PC-3 and comparable to curcumin as the positive control. Results indicated that this composition–activity associative approach is advantageous to finding those bioactive principles efficiently within active extracts. This correlative association can be employed in further studies focused on the targeted isolation of anti-proliferative compounds from Genista plants and accessions.

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“…These herbal teas are used not only as refreshment drinks but also as traditional remedies for various ailments, including obesity (Chien et al., 2016 ; Lingesh et al., 2019 ; Paranjpe et al., 1990 ; Priya & Veeranjaneyulu, 2016 ). Phenolic compounds, due to their antioxidant potential, have shown various biological and pharmacological activities (Hussain et al., 2013 ; Shah et al., 2020 ). Therefore, polyphenol‐rich plant extracts have gained much interest by pharmacologists due to various potential biological activities (Shah et al., 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of polyphenol‐rich traditional herbal teas on obesity and oxidative stress in rats fed a high‐fat–sugar diet

Iftikhar

Hussain

Chatha

et al. 2022

Food Science & Nutrition

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Analysis of other phenolics (capsaicin, gingerol, and alkylresorcinols)

Cited by 8 publications

References 76 publications

Environmental concern regarding the effect of humidity and temperature on 2019-nCoV survival: fact or fiction

Environmental concern regarding the effect of humidity and temperature on 2019-nCoV survival: fact or fiction

Identification of Anti-Proliferative Compounds from Genista monspessulana Seeds through Covariate-Based Integration of Chemical Fingerprints and Bioactivity Datasets

Effects of polyphenol‐rich traditional herbal teas on obesity and oxidative stress in rats fed a high‐fat–sugar diet

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