Effects of polyphenol‐rich traditional herbal teas on obesity and oxidative stress in rats fed a high‐fat–sugar diet

Iftikhar, Neelam; Hussain, Abdullah Ijaz; Chatha, Shahzad Ali Shahid; Sultana, Nahida; Rathore, Hassaan Anwer

doi:10.1002/fsn3.2695

Cited by 23 publications

(32 citation statements)

References 38 publications

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“…Star anise tea (SAT) was prepared as reported previously [ 16 ]. Briefly, a 20-g dried and grounded plant sample (mesh size 80) was shaken in 200 mL distilled water in an orbital shaker (Gallenkamp, UK) for continuous agitation at 180 rpm for 28 h at 55 °C temperature.…”

Section: Methodsmentioning

confidence: 99%

“…The total phenolic (TP) and total flavonoid (TF) contents of SAT extract were measured using methods as described previously [ 16 ]. For TP contents, the standard curve of gallic acid solution (10–80 ppm concentration) and results were calculated using equation (y = 0.026x + 0.000, R 2 = 0.997) and reported as mg of TP contents per gram of plant material, measured as gallic acid equivalent.…”

Section: Methodsmentioning

confidence: 99%

“…Polyphenols are further classified into two main groups, that is, flavonoids (e.g., flavanols, flavanols, flavanones, flavanones, isoflavones and anthocyanins) and non-flavonoids (e.g., phenolic acids, stillbenes, tannins, lignans, and xanthones). The use of plants’ bioactive constituents including polyphenols is gaining more interest day by day due to their prescribed role in human health research [ 1 , 5 , 15 , 16 ]. The relationship between polyphenols consumption and human health has been reported with special reference to oxidative stress, hypertension, cardiovascular diseases, diabetes, cancers and obesity [ 1 , 5 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…The use of plants’ bioactive constituents including polyphenols is gaining more interest day by day due to their prescribed role in human health research [ 1 , 5 , 15 , 16 ]. The relationship between polyphenols consumption and human health has been reported with special reference to oxidative stress, hypertension, cardiovascular diseases, diabetes, cancers and obesity [ 1 , 5 , 16 , 17 , 18 ]. In obesity, flavonoids and phenolic acids could regulate adipocyte metabolism to limit the growth of adipose tissue and are being used in the improvement of various natural weight management products [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…The relationship between polyphenols consumption and human health has been reported with special reference to oxidative stress, hypertension, cardiovascular diseases, diabetes, cancers and obesity [ 1 , 5 , 16 , 17 , 18 ]. In obesity, flavonoids and phenolic acids could regulate adipocyte metabolism to limit the growth of adipose tissue and are being used in the improvement of various natural weight management products [ 16 , 17 ]. Therefore, polyphenols or polyphenol-rich products can be safe, affordable, efficient and economical anti-obesity agents [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Anti-Obesity, and Hypolipidemic Effects of Polyphenol Rich Star Anise (Illicium verum) Tea in High-Fat-Sugar Diet-Induced Obesity Rat Model

et al. 2022

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Star anise (Illicium verum Hook. fil.) is commonly utilized as a culinary and medicinal fruit and is most famous in indigenous systems of medicine. The present research work aims to appraise and validate the potential of polyphenol-rich star anise tea (SAT) on oxidative stress, obesity and related biochemical parameters in high-fat-sugar-diet (HFSD)-induced obesity model in rats. SAT was prepared using the traditional method in warm water. The Reverse Phase High Pressure Liquid Chromatography (RP-HPLC) analysis was performed for the simultaneous determination of phenolic acids and flavonoids in SAT. Two doses (250 and 500 mg/kg body weight) were selected to investigate the anti-obesity potential of SAT using HFSD-induced obese rat model. Major (>5 mg/100 mL) phenolic acids in SAT were p-coumeric acid, gallic aid, cinamic acid, chlorogenic acid and ferulic acid while catechin and rutin were the major flavonoids detected in the SAT. SAT exhibited 51.3% DPPH radical scavenging activity. In vivo study showed that higher doses of SAT (500 mg/kg body weight) significantly reduced the body weight increase (74.82%) and BMI (0.64 g/cm2). Moreover, significant reductions in the levels of serum total cholesterol, triglyceride, LDL and VLDL were recorded in all the treatment groups in comparison to the HFSDC group. Furthermore, SAT reduced the alterations in MDA, SOD and GSH levels of experimental groups thus showing the potential against oxidative stress. The SAT-500 group showed a significant decrease in the elevated kidney and liver weights and atherogenic index in comparison to the HFSDC group. The present study proved that SAT exhibited strong protective effects against obesity and oxidative stress, especially at higher doses.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Anti-Obesity, and Hypolipidemic Effects of Polyphenol Rich Star Anise (Illicium verum) Tea in High-Fat-Sugar Diet-Induced Obesity Rat Model

et al. 2022

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Phenolic Profile of Seedless Ziziphus mauritiana Fruits and Leaves Extracts with In Vivo Antioxidant and Anti‐Inflammatory Activities: Influence on Pro‐Inflammatory Mediators

Khanam,

Ijaz Hussain,

Mohammed

et al. 2024

Chemistry & Biodiversity

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The study aimed to assess the antioxidant and anti‐inflammatory activities of polyphenol‐rich extracts of seedless variety of Ziziphus mauritiana (SZM). Reverse Phase High Performance Liquid Chromatography analysis of SZM leaves and fruit extracts in ethanol revealed the presence of sixteen phenolics including chlorogenic acid, p‐coumeric acid, gallic acid, kaempferol and rutin. Leaf extract showed higher total phenolic and total flavonoid contents (177.6 mg/100 g and 46.2 mg/100 g) than in fruit extract (137.8 mg/100 g and 14.1 mg/100 g). The leaf extract exhibited higher DPPH radical‐scavenging activity (63.5%) than the fruit extract (58.2%). The anti‐inflammatory activity was evaluated on carrageenan‐induced rat model and suppression of inflammatory biomarkers (Interleukin‐6, Tumor necrosis factor‐α and CRP) were studied. The fruit extract exhibited inhibition (98.1%) at the dose of 500 mg/kg body weight (BW), comparable to the indomethacin (98.4%). Both extracts suppressed the inflammatory biomarkers, but pronounced results showed by the fruit extract including CRP, IL‐6, and TNF‐α. The leaf extract demonstrated the higher antioxidant potential as evident from the superoxide dismutase, catalase, malondialdehyde, glutathione peroxidase and glutathione levels. These findings suggest that SZM leaf and fruit extracts possess potential antioxidant and anti‐inflammatory properties and can play a significant role in mitigating oxidative stress.

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Research progress on the regulation of oxidative stress by phenolics: the role of gut microbiota and Nrf2 signaling pathway

Liu,

Wang,

Podio

et al. 2023

J Sci Food Agric

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In recent years, the increase in high‐calorie diets and sedentary lifestyles has made obesity a global public health problem. An unbalanced diet promotes the production of proinflammatory cytokines and causes redox imbalance in the body. Phenolics have potent antioxidant activity and cytoprotective ability. They can scavenge free radicals and reactive oxygen species, and enhance the activity of antioxidant enzymes, thus combating the body's oxidative stress. They can also improve the body's inflammatory response, enhance the enzyme activity of lipid metabolism, and reduce the contents of cholesterol and triglyceride. Most phenolics are biotransformed and absorbed into the blood after the action by gut microbiota, then these metabolites undergo phase I and II metabolism and regulate oxidative stress by scavenging free radicals and increasing expression of antioxidant enzymes. Phenolics induce the expression of genes encoding anti‐oxidant enzymes and phase II detoxification enzymes by stimulating Nrf2 to enter the nucleus and bind to the ARE after uncoupling from Keap1, thereby promoting the production of antioxidant enzymes and phase II detoxification enzymes. The absorption rate of phenolics in the small intestine is extremely low. Most phenolics reach the colon, where they interact with the microbiota and undergo a series of metabolism. Their metabolites will reach the liver via the portal vein and undergo conjugation reactions. Afterward, the metabolites reach the whole body to exert biological activity by traveling with the systemic circulation. Phenolics can promote the growth of probiotics, reduce the ratio of Firmicutes/Bacteroidetes (F/B), and improve intestinal microecological imbalance. This paper reviewed the nutritional value, bioactivity, and antioxidant mechanism of phenolics in the body, aiming to provide a scientific basis for the development and utilization of natural antioxidants and provide a reference for elucidating the mechanism of action of phenolics for regulating oxidative stress in the body.This article is protected by copyright. All rights reserved.

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Effects of polyphenol‐rich traditional herbal teas on obesity and oxidative stress in rats fed a high‐fat–sugar diet

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 23 publications

References 38 publications

Antioxidant, Anti-Obesity, and Hypolipidemic Effects of Polyphenol Rich Star Anise (Illicium verum) Tea in High-Fat-Sugar Diet-Induced Obesity Rat Model

Antioxidant, Anti-Obesity, and Hypolipidemic Effects of Polyphenol Rich Star Anise (Illicium verum) Tea in High-Fat-Sugar Diet-Induced Obesity Rat Model

Phenolic Profile of Seedless Ziziphus mauritiana Fruits and Leaves Extracts with In Vivo Antioxidant and Anti‐Inflammatory Activities: Influence on Pro‐Inflammatory Mediators

Research progress on the regulation of oxidative stress by phenolics: the role of gut microbiota and Nrf2 signaling pathway

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