Analysis of peripheral nerve and autonomic nervous system function
and the stage ofmicroangiopathy in patients with secondary
Raynaud’s phenomenon in the course of connective tissue diseases

Gosk−Bierska, Izabela; Misterska-Skóra, Maria; Wasilewska, Marta; Bilińska, Małgorzata; Gosk, Jerzy; Adamiec, Rajmund; Koszewicz, Magdalena

doi:10.17219/acem/75618

Cited by 11 publications

(7 citation statements)

References 21 publications

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“…Increased latency in SSR may originate from milder neuropathic damage or from loss of thicker axons, changes in cholinergic fibres and/or sweat glands and synaptic transmission interruption through central processing. 23 Since there was no evidence of afferent somatic fibres or central nervous system or sweat gland diseases in the present study, it is suggested that the source of SSR latency abnormalities might be the sympathetic efferent nerves.…”

Section: Discussioncontrasting

confidence: 53%

“…noted a significantly low SSR amplitude and long latency in their palms and soles. 23 In patients with SRP, no relationship was found between SSR and microangiopathy; this confirmed that these two processes occur independently in patients with SRP. The authors concluded that normal peripheral nerve function with impaired ANS suggested the central origin of SRP.…”

Section: Discussionmentioning

confidence: 54%

“…Abnormal SSR habituation might also result from the central mechanism. 23 Gledhill et al . showed ANS dysfunction in nine SRP patients with cardiovascular autonomic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

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Is There Any Sympathetic Skin Response (SSR) Abnormality in Raynaud Phenomenon?

Emad

Farpour

Ahmed

et al. 2021

Sultan Qaboos Univ Med J

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Objectives: Sympathetic skin response (SSR) is a technique for assessment of the damage of peripheral neuropathies and the disorders of the sympathetic system. This study aimed to evaluate SSR among patients with Raynaud phenomenon (RP). Methods: Between January 1, 2015 and December 30, 2018, about 20 patients with RP and 20 healthy subjects as the control group were recruited from patients referring to the Outpatient Clinics of Shiraz medical University. All the participants were clinically examined, and the SSR was performed using a standard protocol. SSR is abnormal when the latency is prolonged and/or the amplitude reduced. Results: Raynaud's group consisted of 19 women (95 %) and 1 male (5%). 3 patients (15 %) with primary Raynaud's phenomenon (PRP) and 17 patients (85%) with secondary Raynaud's phenomenon (SRP). The control group consisted of 16 women (80%) and 4 males (20%). The mean age of the Raynaud's group and control subjects was 43.1±9 and 36.7±8.6 years, respectively. The SSR to the electrical stimulus was absent in 3 patients (PRP patients). The total median nerve mean latencies in the upper limb were 1.9±0.57 and 1.19±0.52 seconds for the Raynaud's group and control groups, respectively (p <0.001). These findings revealed significantly prolonged SSR latencies in the Raynaud's group, while the mean amplitude showed no significant differences in both groups (p =0.756). Conclusion: Absence or prolonged latency of SSR was associated with the disorders of the unmyelinated axons in the sympathetic system. Our findings suggested the disorders of unmyelinated axons in Raynaud's phenomenon. Keywords: Raynaud Disease; Autonomic Nervous System; Electrodiagnosis; Sympathetic Fibers; Nerve Conduction.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 54%

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Is There Any Sympathetic Skin Response (SSR) Abnormality in Raynaud Phenomenon?

Emad

Farpour

Ahmed

et al. 2021

Sultan Qaboos Univ Med J

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“…19 Central autonomous involvement has also been suggested to be important in the pathogenesis of connective tissue disease-associated RP. 20 Cold stimuli causes relocation of alpha 2c-adrenergic receptors from the Golgi apparatus to the cell surface, through activation of the rho kinase, which then increases the sensitivity of contractile proteins and subsequent vasoconstriction. 21 Increased alpha 2c-adrenergic expression in vascular smooth muscle cells has been reported in RP.…”

Section: Vascularmentioning

confidence: 99%

Raynaud's phenomenon

Haque

Hughes

2020

Clinical Medicine

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“…Fries also demonstrated the increased skin resistance to the passage of weak electric current in the digits of patients with SSc [ 10 ]. This was interpreted as autonomic underactivity, and it was suggested that this might be a compensatory mechanism to increase blood flow to ischemic areas [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Sympathetic skin response in patients with systemic sclerosis and rheumatoid arthritis

Badry

Gamal

Hassanien

et al. 2018

Egypt J Neurol Psychiatry Neurosurg

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BackgroundSympathetic skin response (SSR) is a technique to assess the sympathetic cholinergic pathways. Sympathetic dysfunction may participate in the development of pain, which is the major complaint in patients with systemic sclerosis (SSc) and rheumatoid arthritis (RA).ObjectivesIn this study, we aimed to assess the autonomic dysfunction in patients with (SSc) and (RA) using SSR as a simple neurophysiologic test.MethodsPalmar SSR to median nerve electrical stimulation was recorded in 21 patients with SSc, 39 patients with RA, and in 60 healthy age and sex-matched control subjects.ResultsPalmar SSR to median nerve stimulation (of SSc patients and RA patients) shows significantly delayed latency and reduced amplitude in comparison to the control group. SSR of SSc patients has significantly delayed latency and reduced amplitude when compared to RA patients. Moreover, six SSc patients have delayed SSR in spite of the absence of manifestations of polyneuropathy.ConclusionsPatients with SSc and RA have features of autonomic dysfunction with more affection of SSc patients.

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Analysis of peripheral nerve and autonomic nervous system function and the stage ofmicroangiopathy in patients with secondary Raynaud’s phenomenon in the course of connective tissue diseases

Cited by 11 publications

References 21 publications

Is There Any Sympathetic Skin Response (SSR) Abnormality in Raynaud Phenomenon?

Is There Any Sympathetic Skin Response (SSR) Abnormality in Raynaud Phenomenon?

Raynaud's phenomenon

Sympathetic skin response in patients with systemic sclerosis and rheumatoid arthritis

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