Analysis of Pharmaceutical Excipient MCC Avicel PH102 Using Compaction Equations

Abstract

This paper focuses on the characterization of the tabletting process and analysis one of the most common pharmaceutical excipients MCC Avicel PH102 by Heckel, Kawakita, Cooper-Eaton and Adams compaction equations. Experimental material was determined by measuring its parameters as particle size distribution, angle of wall friction and flow properties and for more detailed characteristics of the material particles, microscopy images of the powder before and after compressing were created.

Aceclofenac Fast Dispersible Tablet Formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics

“…For evaluating compressional behavior, ten tablets from each formulation were prepared by applying different compressional pressure 7.72, 23 reported that both these compaction equations are suitable for describing the compression process of powder materials based on Avicel PH 102 (24). Different parameters of Heckel and Kawakita equations were derived from these plots i.e.…”

Dynamic Image Analysis to Determine Granule Size and Shape, for Selected High Shear Granulation Process Parameters

“…Microcrystalline cellulose (Avicel PH101, FMC Biopolymer) was used as the experimental powder material, which was obtained from the IMCD group. This material is commonly used in the pharmaceutical industry as a binder, lubricant or a solvent in the production of solid dosage forms [12]. Avicel average particle size is dmean = 46 µm, bulk density ρB = 333 kg/m 3 , true density ρT = 1580 kg/m 3 .…”

Effect of Bulk Density on Tensile Strength of Tablets Prepared by Using Hiceltmmcc (Microcrystalline Cellulose) and Hiceltmsmcc (Silicified Microcrystalline Cellulose)

“…Thereafter it is washed and filtered with ammonia with the help of filter press for getting the conductivity below 75 µS/cm, pH is neutral. [15] Then prepare slurry by addition of water in wet cake of MCC and dried with the help of spray dryer and process flow chart mentioned in fig.1. …”

“…[9] www.wjpr.net [15] Untapped Bulk Density [2] Weigh accurately 20g sample by using electronic digital balance (Mettler Toledo, Model No-ML802/A01) and poured slowly from side wall into 100 ml capacity "Class A" graduated measuring glass cylinder. Level the surface of sample in cylinder by slow movement and observed the occupied volume.…”