Qualitative and quantitative procedures for the analysis of creams of the oil-in-water type are reviewed and discussed, with special attention to the clean-up methods. It is concluded that systematic investigations have hardly been reported, except for creams containing corticosteroids.It5-I98O Pharmaceutisch Weekblad I429 ABSTRACT A simple and rapid method for the spectrofluorimetric determination of adrenaline and some related compounds in pharmaceutical preparations was developed. The method is based on the measurement of the fluorescence of the compounds at their respective emission maxima after excitation of solutions in o. I M sodium dihydrogen phosphate. The influence of several additives (drugs, preservatives, buffers, etc.) was studied. With the method amounts of 1-4 /zg/ml of the various drugs could be determined. The method was tested with a variety of pharmaceutical formulations.