Analysis of phenolic acids by non-aqueous capillary electrophoresis after electrokinetic supercharging

Lu, Yongming; Breadmore, Michael C.

doi:10.1016/j.chroma.2010.08.078

Cited by 33 publications

(18 citation statements)

References 52 publications

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“…As reported in FASI works , a short plug of pure solvent injected in the beginning of the capillary before the electrokinetic injection improves the performance. ACN, MeOH, ACN/MeOH (50:50 v/v), 1‐butanol, and ethyleneglycol were tested in the plug.…”

Section: Resultsmentioning

confidence: 68%

On‐line preconcentration of perfluorooctanoic acid and perfluorooctanesulfonic acid by nonaqueous capillary electrophoresis

et al. 2012

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Separation of major environmental pollutants as perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) by capillary electrophoresis is reported for the first time. It is not possible to resolve the solutes in an aqueous media. However, the use of methanol and acetonitrile as the background electrolyte (BGE) solvents allowed their rapid separation in an uncoated capillary. A major effort was put into BGE optimization in respect to both separation efficiency and detection for further on-line preconcentration. 5 mmol.L⁻¹ naphthalene-1-sulfonic acid and 10 mmol.L⁻¹ triethylamine dissolved in ACN/MeOH (50:50 v/v) provided best separation and detection conditions. Next, the large-volume sample stacking and the field-amplified sample injection were applied and compared. Large-volume sample stacking improved limits of detection (LODs) with regard to the standard injection by 69 times for PFOA and 143 times for PFOS with LODs of 280 and 230 nmol.L⁻¹, respectively. Field-amplified sample injection improved LODs 624 times for PFOAand 806 times for PFOS with LODs 31 and 40 nmol.L⁻¹, respectively. Both preconcentration methods showed repeatabilities of migration times less than 1.2% RSD intraday and 6.6% RSD interday. The method was applied on PFOA and PFOS analysis in a sample of river water treated with solid-phase extraction, which further improved LOD toward 5.6 × 10⁻¹⁰ mol.L⁻¹ for PFOS and 6.4 × 10⁻¹⁰ mol.L⁻¹ for PFOA and allows the method to be used for river water contamination screening or decomposition studies.

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Section: Resultsmentioning

confidence: 68%

On‐line preconcentration of perfluorooctanoic acid and perfluorooctanesulfonic acid by nonaqueous capillary electrophoresis

et al. 2012

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“…The developed PA‐EKS system allowed the injection of the NSAIDs for up to 60 min at ‒14 kV and the sensitivity was enhanced by up to 47 000‐folds with LODs down to 15 ng/L. Lu and Breadmore utilised EKS in non‐aqueous CE conditions for pre‐concentration of phenolic acids. The authors reversed the EOF through formation of a polyelectrolyte multilayer coating based on poly (diallyldimethylammonium chloride) and polystyrene sulfonate.…”

Section: Sequential Stacking Methodsmentioning

confidence: 99%

Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2010–2012)

et al. 2013

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CE has been alive for over two decades now, yet its sensitivity is still regarded as being inferior to that of more traditional methods of separation such as HPLC. As such, it is unsurprising that overcoming this issue still generates much scientific interest. This review continues to update this series of reviews, first published in Electrophoresis in 2007, with updates published in 2009 and 2011 and covers material published through to June 2012. It includes developments in the field of stacking, covering all methods from field amplified sample stacking and large volume sample stacking, through to isotachophoresis, dynamic pH junction and sweeping. Attention is also given to online or inline extraction methods that have been used for electrophoresis.

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“…The new system permitted increase in injection time by 80% over the previous system without loss of resolution, as it allowed the analytes to be injected at À10 kV for 3 min. The detection sensitivity was enhanced by 3440-fold when compared to conventional hydrodynamic injection, and almost eight times better than other stacking techniques, that gave LODs down to 0.22 mg/L [37].…”

Section: Eks In Capillary Electrophoresismentioning

confidence: 98%

High‐sensitivity capillary and microchip electrophoresis using electrokinetic supercharging

Dawod

Chung

2011

J of Separation Science

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Electrokinetic supercharging (EKS) is considered as one of the most powerful online preconcentration techniques in electrophoresis. It combines the efficient preconcentration power of field-amplified sample injection and the exceptional selective nature of transient isotachophoresis. It has a wide range of applications to different types of analytes ranging from small ions to large proteins and DNA fragments. This comprehensive review--up to date--provides listing for all the works, developments, and advances in EKS. The review will pay particular attention to innovations, new methodologies for manipulation, challenges for improving the detection sensitivity, and various applications of EKS in capillaries and microchips.

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Analysis of phenolic acids by non-aqueous capillary electrophoresis after electrokinetic supercharging

Cited by 33 publications

References 52 publications

On‐line preconcentration of perfluorooctanoic acid and perfluorooctanesulfonic acid by nonaqueous capillary electrophoresis

On‐line preconcentration of perfluorooctanoic acid and perfluorooctanesulfonic acid by nonaqueous capillary electrophoresis

Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2010–2012)

High‐sensitivity capillary and microchip electrophoresis using electrokinetic supercharging

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