Analysis of Prognostic and Immunohistochemical Factors in Gastrointestinal Stromal Tumors With Malignant Potential

Özgüç, Halil; Yılmazlar, Tuncay; Yerci, Ömer; Soylu, Rusen; Tümay, Latif Volkan; Filiz, Gülaydan; Zorluoğlu, Abdullah

doi:10.1016/j.gassur.2004.07.003

Cited by 30 publications

(19 citation statements)

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“…GIST is the most common mesenchymal neoplasm of the gastrointestinal (GI) tract [9][10][11]. Because GISTs are neoplasms with low malignant potential, they would necessitate lifelong followup or resection.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic band ligation of small gastric stromal tumors and follow-up by endoscopic ultrasonography

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Endoscopic band ligation of small gastric stromal tumors and follow-up by endoscopic ultrasonography

et al. 2006

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“…Only a few studies have analyzed the prognostic value of molecular cell differentiation proteins in GIST [6][7][8][9]. In this study we assessed the impact of cell markers and clinical features on survival as well as recurrence rate in a series of 35 GIST patients.…”

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confidence: 99%

Protein S100 as Prognostic Marker for Gastrointestinal Stromal Tumors: A Clinicopathological Risk Factor Analysis

Perez

Demartines

Meier

et al. 2007

Journal of Investigative Surgery

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Gastrointestinal stromal tumors (GISTs) are a heterogenous group of mesenchymal neoplasms ranging from semibenign tumors to highly aggressive neoplasms. Predicting their clinical behavior is challenging and criteria delineating benign from malignant cases are controversially discussed. The aims of the present study were to define the clinicopathological features of 35 GISTs and to determine whether any specific parameters were associated with the patient's outcome. In the present series, protein S100 (S100) expression was found in 13/35 (37%) patients with a varying staining intensity ranging between strong and moderate. The multivariate statistical analysis in the S100-positive group revealed a significantly poorer survival (p = .0058) and a tendency for higher recurrence (p = .052) compared to the negative GIST patients. Furthermore, the statistical analysis disclosed a correlation between the expression of CD117, CD34, desmin, and alpha-smooth muscle actin and survival or recurrence (p > .05). Positive immunoreactivity was seen for CD117 in 25 (71%) patients and for CD34 in 19 (54%) patients. In addition we confirmed the previously reported impact of initial tumor size on survival and recurrence rate (p = .034 and p = .039). The series was also analyzed according to established prognostic factors (tumor size and mitotic activity), which indicated that 77% of S100-positive cases were at high risk for malignant tumor behavior, 15% at intermediate risk, and 8% at low risk. Based on these findings, we suggest that protein S100 represents an additional prognostic factor to better define the malignant potential of GISTs and stratify the risk for each patient.

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“…10 In addition, a male sex, high age, high MIB-1 grade, desmin staining, and an incomplete resection have been shown to be factors having a signifi cant impact on the overall survival. 4,11,12 The consensus risk grouping of GISTs has been recently proposed; the prediction of the biological behavior of GISTs is based on two prognostic factors, the tumor size and the number of mitoses and many reports support this risk category. 1,13 Because of the inaccuracy of the mitotic count, Hasegawa et al attempted to defi ne the MIB-1 labeling index as more objective pathological characteristics of malignancy and thus evaluate the risk using the combination of the tumor size and the MIB-1 score.…”

Section: Discussionmentioning

confidence: 99%

The Outcome of Gastrointestinal Stromal Tumors (GISTs) After a Surgical Resection in Our Institute

et al. 2007

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Analysis of Prognostic and Immunohistochemical Factors in Gastrointestinal Stromal Tumors With Malignant Potential

Cited by 30 publications

References 33 publications

Endoscopic band ligation of small gastric stromal tumors and follow-up by endoscopic ultrasonography

Endoscopic band ligation of small gastric stromal tumors and follow-up by endoscopic ultrasonography

Protein S100 as Prognostic Marker for Gastrointestinal Stromal Tumors: A Clinicopathological Risk Factor Analysis

The Outcome of Gastrointestinal Stromal Tumors (GISTs) After a Surgical Resection in Our Institute

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