Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment

Abstract

Background: The interaction between cancer cells and stromal cells has a significant contribution in tumorigenesis and tumor development, and plays an anti-tumor immune effect under the regulation of drug resistance-related genes, which affects the outcome of patients. Coiled-coil domain-containing protein 73 (CCDC73), DLG associated protein 1 (DLGAP1), dermatan sulfate epimerase like (DSEL), estrogen receptor 1 (ESR1), and SEC14-like 5 (SEC14L5) were identified as drug resistance-related genes in lung cancer.However, these genes have no clear value in lung cancer in terms of expression and prognosis.Methods: ONCOMINE, GEPIA, UALCAN, cBioPortal, GeneMANIA, STRING, and TIMER were utilized in this study. Results:The transcriptional expression level of DLGAP1 was remarkably decreased in lung cancer tissues, while the transcriptional level of SEC14L5 was significantly increased. The pathological stage of lung adenocarcinoma (LUAD) was tightly correlated with the expression of SEC14L5. The lung cancer patients with high transcription level of CCDC73 gene tended to have a good prognosis. The function of drug resistance-related genes is mainly related to RNA polymerization. Our results showed that infiltration of six types of immune cells (dendritic cells, macrophages, neutrophils, B cells, CD4 + T cells, and CD8 + T cells) significantly correlated with the expression of these drug resistance-related genes.Conclusions: Novel screening for immunotherapy targets and prognostic biomarkers in lung cancer may draw inspiration from our results.

New Perspectives on Sex Steroid Hormones Signaling in Cancer-Associated Fibroblasts of Non-Small Cell Lung Cancer

“…Immune-checkpoint inhibitors are widely used for lung cancer treatment [1]; therefore, the number of studies on the effects of estrogen on tumor immunity in lung cancer is increasing and data analyses using public databases have shown that ER and/or PgR expression in cancer tissues correlate with immune cell infiltration. Zhu et al reported that ERα expression is positively correlated with the infiltration of dendritic cells, macrophages, neutrophils, B cells, CD4+ T cells, and CD8+ T cells; however, there is no correlation between ERα expression and the prognosis [80]. Oh et al analyzed RNA seauencing data from The Cancer Genome Atlas and demonstrated that increased ERα was associated with high expression of immune-checkpoint markers, whereas increased PgR was associated with high levels of TGF-β genes [81].…”

Identification of Driver Epistatic Gene Pairs Combining Germline and Somatic Mutations in Cancer

“…To generate new hypotheses regarding the mechanism of cancer, we performed an analysis of the functions of the identified genes and their corresponding protein interaction networks. A previous study has shown that lung cancer patients with a high transcription level of the CCDC73 gene tend to have a good prognosis [32]. Another study found a relationship between the expression of the serotonin 2B (HTR2B) receptor and human uveal melanoma [33].…”