Analysis of propolis from Baccharis dracunculifolia DC. (Compositae) and its effects on mouse fibroblasts

Funari, Cristiano Soleo; Ferro, Vicente de Oliveira; Mathor, Mônica Beatriz

doi:10.1016/j.jep.2006.11.032

Cited by 60 publications

(52 citation statements)

References 41 publications

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“…The yields of the selected markers were higher than those obtained in the other studies, except for DHCA, whose value was about 60% of value reported by Funari et al (2007). The yields of p-coumaric acid and kaempferide were approximately 60% higher than those obtained by Funari et al (2007) and about 2 times and 3 times higher than the values obtained by Biscaia and Ferreira (2009), respectively. These three samples of propolis were obtained from different places.…”

Section: Extraction Yield Of Dry Ethanolic Extract Of Propolis (Eep)contrasting

confidence: 64%

“…The global extraction yield (39.5%) was similar than that obtained by Funari et al (2007) and slightly lower than that obtained by Biscaia and Ferreira (2009). The yields of the selected markers were higher than those obtained in the other studies, except for DHCA, whose value was about 60% of value reported by Funari et al (2007).…”

Section: Extraction Yield Of Dry Ethanolic Extract Of Propolis (Eep)supporting

confidence: 40%

“…These compounds represent approximately 10% in mass of the dry EEP and were chosen for analysis because they represent the main phenolic components of this type of propolis, with Artepillin C being the most important component due to its biological properties. Table 1 shows the global yield and the yields of the 4 markers of the dry ethanolic propolis extract (EEP), and also makes a comparison with the ethanolic extracts obtained by Funari et al (2007) and by Biscaia and Ferreira (2009).…”

Section: Methodsmentioning

confidence: 99%

“…These three samples of propolis were obtained from different places. The sample used in this work was obtained from state of Minas Gerais, the sample of Funari et al (2007) was from "Serra do Japi, state of São Paulo and the sample of Biscaia and Ferreira (2009) was from the state of Paraná. Another important variable that affects the composition, is the season that the sample is collected, as shown in the work of Simões-Ambrosio et al (2010), where the composition of several compounds were analysed, and the concentration of Artepillin C ranged between 1 and 65 mg/g in the course of the year.…”

Section: Extraction Yield Of Dry Ethanolic Extract Of Propolis (Eep)mentioning

confidence: 99%

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Supercritical CO2 extraction of raw propolis and its dry ethanolic extract

Paviani

Saito

Dariva

et al. 2012

Braz. J. Chem. Eng.

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-Three types of propolis extract were prepared and analyzed with respect to their global extraction yields and with respect to the concentration of the following markers: 3,5-diprenyl-4-hydroxycinnamic acid; 3-prenyl-4-hydroxycinnamic acid; 4-hydroxycinnamic acid and 4-methoxy-3,5,7-trihydroxyflavone. The extract EEP (ethanolic extract of propolis) was obtained by the conventional method from raw propolis using ethanol as solvent. The extracts (SFE) were obtained by supercritical solvent extraction from the raw propolis using supercritical carbon dioxide (sc-CO 2 ), with and without the addition of ethanol as a co-solvent. The fractionated supercritical extracts (FSCE) were obtained by fractionation (extract and raffinate) of the dry EEP with sc-CO 2 . EEP yields of 39.5% were obtained and maximum global extraction yields were 7.3% for SFE with no co-solvent, 51% for SFE with 15% ethanol and 18% for the FSCE extract fraction. The concentrations of the markers in the different extracts differed as a function of the operational parameters, indicating that the addition of co-solvent and the selectivity of sc-CO 2 could be manipulated so as to obtain extracts with the yields and concentrations of interest.

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Section: Extraction Yield Of Dry Ethanolic Extract Of Propolis (Eep)contrasting

confidence: 64%

Section: Extraction Yield Of Dry Ethanolic Extract Of Propolis (Eep)supporting

confidence: 40%

Section: Methodsmentioning

confidence: 99%

Section: Extraction Yield Of Dry Ethanolic Extract Of Propolis (Eep)mentioning

confidence: 99%

See 2 more Smart Citations

Supercritical CO2 extraction of raw propolis and its dry ethanolic extract

Paviani

Saito

Dariva

et al. 2012

Braz. J. Chem. Eng.

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“…Phenolic compounds are potent antioxidants, and epidemiological studies have suggested a direct correlation between their high intake with diet and reduced risk of coronary heart disease mortality by suppressing the oxidation of low-density lipoprotein [19]. Cinnamic acid and p-coumaric acid antiulcer effects have been demonstrated (Frey et al, 2001;Pereira et al, 2003;Funari et al, 2007;Siddaraju and Shylaja, 2007;Barros et al, 2008). Two new cinnamoyl 1-deoxyglucosides, cinnamic acid, besides two new coumaroyl 1-deoxyglucosides, were isolated by semi-preparative HPLC and the structures was established using NMR experiments Nwidu et al, 2011. This study quantitatively isolate, elucidate the active compounds from the EAF by semi-preparative HPLC and subjecting the fraction to radical scavenging assays (RSA).…”

Section: Introductionmentioning

confidence: 99%

Antiulcer Effects of Ethyl acetate Fraction of Carpolobia lutea Leaf

Nwidu¹

2012

J. App. Pharm. Sci.

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Carpolobia lutea leaves (CLL) (Polygalaceae) were earlier screened and the antiulcer ethnomedicinal claim established. This article seeks to quantitatively isolate, elucidate the active compounds from most active CLL fraction. Fractionation was by semi-preparative HPLC; the active fraction was subjected to radical scavenging assays (RSA) and quantification of the total phenolic content (TPC) were also executed. Results: Ethyl acetate fraction (EAF) was observed to be the most pharmacologically active antiulcer fraction when screened using acute ulcer models induced in rodents. The EAF demonstrated significant (p < 0.05-0.001) antiulcer activity in various in vivo induced ulceration models by reducing the ulcer index and increasing the preventive ratio. The EAF demonstrated > 70% in TPC and < 20 % in RSA. Cinnamic and coumaric acids derivatives were isolated from EAF. Cinnamic acids have been implicated and patented as antiulcer agent. Isolated compounds could in part mediate the observed pharmacological activities which lend credence to its ethnobotanical uses.

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PVA hydrogels loaded with a Brazilian propolis for burn wound healing applications

Oliveira

McGuinness

Rouze

et al. 2015

J of Applied Polymer Sci

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PVA hydrogels offer many suitable characteristics for burn wound dressings. However, unmodified PVA gels do not act against infection. Propolis is a natural antimicrobial agent suitable for incorporation into PVA gels. PVA-propolis gels were produced by freeze-thawing method, and their microstructure, mechanical, and swelling properties (in standard PBS and a PBS-based solution with pH 4.0) were characterized. The propolis release profiles and the gel's antibacterial and cytotoxicity properties were also investigated. The presence of propolis in the gels interfered with the PVA crystallization profile and with the mechanical properties. All samples swelled at least 400% in both media. The propolis was mostly released to the media in the first day of immersion. PVA-propolis gels with concentrations of 15% propolis or more were active against the gram-positive bacterium Staphylococcus aureus, which is associated with initial colonization of the wound. All PVA-propolis samples acted as barriers to microbial penetration.

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Analysis of propolis from Baccharis dracunculifolia DC. (Compositae) and its effects on mouse fibroblasts

Cited by 60 publications

References 41 publications

Supercritical CO2 extraction of raw propolis and its dry ethanolic extract

Supercritical CO2 extraction of raw propolis and its dry ethanolic extract

Antiulcer Effects of Ethyl acetate Fraction of Carpolobia lutea Leaf

PVA hydrogels loaded with a Brazilian propolis for burn wound healing applications

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