Analysis of Prostate Cancer Susceptibility Variants in South African Men: Replicating Associations on Chromosomes 8q24 and 10q11

Fernandez, P.; Salie, Muneeb; Toit, Danielle du; Merwe, André van der

doi:10.1155/2015/465184

Cited by 19 publications

(24 citation statements)

References 47 publications

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“…Notwithstanding, this review not only highlights the disparity of PCa incidence and mortality rates but the disparity in research geared to understanding the disease towards developing therapies for MAA compared to men of European ancestry (MEA). Fairly recent data indicates a decline in PCa incidence, yet, the overall PCa‐related mortality continues to rise among MAA …”

Section: Introductionmentioning

confidence: 99%

Disparities in prostate cancer incidence and mortality rates: Solvable or not?

et al. 2019

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Prostate cancer (PCa) is recognized as a disease possessing not only great variation in its geographic and racial distribution but also tremendous variation in its potential to cause morbidity and death and it, therefore, ought not to be considered a homogenous disease entity. Morbidity and death from PCa are disproportionately higher in men of African ancestry (MAA) who are generally observed to have more aggressive disease and worse outcomes following treatment compared to men of European ancestry (MEA). The higher rates of PCa among MAA relative to MEA appear to be multifactorial and related to inherent differences in biological aggressiveness; a continued lack of awareness of the disease and methods of prevention; a lower prevalence of screen‐detected PCa; comparatively lower access to quality healthcare as well as systemic and institutionalized disparities in the administration of optimal care to MAA in developed countries such as the United States of America where high‐quality care is available. Even when access to quality healthcare is assured in equal access settings, it appears that MAA still have worse outcomes after PCa treatment stage‐for‐stage and grade‐for‐grade compared to MEA, suggesting that, inherent racial, ethnic and biological differences are paramount in predicting poor outcomes. This review has explored the different contributing factors to the current disparities in PCa incidence and mortality rates with emphasis on the incongruence in how research has been conducted in understanding the disease towards developing therapies.

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Section: Introductionmentioning

confidence: 99%

Disparities in prostate cancer incidence and mortality rates: Solvable or not?

et al. 2019

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“…According to an estimate by the American Cancer Society, 180,890 new diagnoses of prostate cancer will be made in 2016, and nearly 26,120 patients will die due to this malignancy (1). Recent data suggest that the prostate cancer incidence is declining, but the overall prostate cancer-related mortality continues to rise among African-American (AA) men (2). …”

Section: Introductionmentioning

confidence: 99%

“…According to publish data, AA men are 1.6 times more susceptible to develop prostate cancer, and about 2 times more likely to die from this disease than EA men. In fact, the disparity in mortality rate between AA and EA men is higher for prostate cancer than that for any other malignancy (2). In general, AA men are often diagnosed with more advanced and aggressive prostate cancer compared to any other racial/ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

Racial disparities in prostate cancer a molecular perspective

et al. 2017

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Prostate cancer incidence and mortality rates are remarkably higher in African-American men as compared to their European-Americans counterparts. Despite these recognitions, precise causes underlying such prevalent racial disparities remain poorly understood. Although socioeconomic factors could account for such differences up to a certain extent, it is now being increasingly realized that such disparity has a molecular basis. Indeed, several differences, including genetic polymorphism, gene mutations, epigenetic modifications, miRNAs alterations, etc., have been reported in malignant prostate tissues from patients of diverse racial backgrounds. Here, we attempt to provide a molecular perspective on prostate cancer racial disparities by gathering available information on these associated factors and discussing their potential significance in disproportionate incidence and clinical outcomes.

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“…Afterward, other studies have provided additional evidence to support the association between 10q11 and PCa susceptibility, including both GWASs and validation studies [49][50][51][52][53][54][55]. One of these PCa risk-associated genetic variants was located in the close proximity of the transcription start site of the gene Microseminoprotein B (MSMB ) which encodes a tumor-suppressor, and was, therefore, even considered as potentially functional.…”

Section: Q11mentioning

confidence: 99%

Genetic Association Studies on Prostate Cancer

Nikolic¹,

Savić‐Pavićević²,

Brajušković³

2016

Prostate Cancer - Leading-Edge Diagnostic Procedures and Treatments

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The modern research on molecular basis of prostate cancer (PCa) development includes studies aiming to identify potential genetic markers which could be used in diagnostics and/or monitoring of PCa. Genome-wide association studies (GWASs) have identified over 75 variants associated with PCa risk. One of the major PCarelated regions identified through GWASs is found to be a segment of 8q24. Other important PCa-susceptibility regions are 17q12, 17q24, 10q11, and 19q13. Candidategene based approach has also provided evidence of association between PCa risk and genetic variants located in functionally significant genes (both protein-coding and noncoding RNA genes) involved in normal prostatic cell growth, malignant transformation, or in the development of metastases. Nevertheless, the success of these studies is questionable, since numerous candidates for PCa-susceptibility variants were identified, but these results failed to replicate. The main aim of both types of genetic association studies on PCa is the identification of potential PCa genetic markers which could be used for constructing reliable algorithms for evaluating the risk for PCa development and/or PCa progression.

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Analysis of Prostate Cancer Susceptibility Variants in South African Men: Replicating Associations on Chromosomes 8q24 and 10q11

Cited by 19 publications

References 47 publications

Disparities in prostate cancer incidence and mortality rates: Solvable or not?

Disparities in prostate cancer incidence and mortality rates: Solvable or not?

Racial disparities in prostate cancer a molecular perspective

Genetic Association Studies on Prostate Cancer

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