Analysis of quinolone residues in edible animal products

Hernández-Arteseros, J. A.; Barbosa, J.; Compañó, R.; Prat, M.D.

doi:10.1016/s0021-9673(01)01505-9

Cited by 206 publications

(101 citation statements)

References 90 publications

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“…It is impossible to achieve chromatographic separations suitable for Sudan dyes residue analysis with fulfillment of requirements as short retention time, absolute resolution, and peak shapes. Therefore, ion-pair agents such as TEA to bind silanol groups were a common practice to decrease peak tailing [25]. The reason is that TEA in the mobile phase competes with the analytes for the active residual silanol groups to improve peak shape.…”

Section: Effect Of Teamentioning

confidence: 99%

Development of a new method for analysis of Sudan dyes by pressurized CEC with amperometric detection

Liu¹,

Zhang²,

Lin³

et al. 2007

Electrophoresis

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A new analytical method, pressurized CEC (pCEC) with amperometric detection (AD) using 1.5 mm RP nonporous silica packed columns has been developed for the rapid separation and determination of four Sudan dyes in hot chilli. The influence of several experimental parameters on the retention behavior has been investigated. The electrochemical oxidation of Sudans I-IV separated by pCEC can be reliably monitored with a carbon electrode at 10.95 V (vs. Ag/AgCl). Fast and efficient separation of the analytes was achieved within 7 min by pCEC under the optimum conditions with an ACN/water (95:5%) mobile phase containing formic acid (pH 4.3), 5% acetone and 0.002% triethylamine using a separation voltage of 12 kV. The detection limits for four Sudan dyes ranged from 8.0 6 10 27 to 1.2 6 10 26 mol/L. To evaluate the feasibility and reliability of this method, the proposed pCEC-AD method was further demonstrated with hot chilli samples spiked with Sudan dyes.

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Section: Effect Of Teamentioning

confidence: 99%

Development of a new method for analysis of Sudan dyes by pressurized CEC with amperometric detection

Liu¹,

Zhang²,

Lin³

et al. 2007

Electrophoresis

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“…Quinolones are antibacterials used for the treatment of infections in both human and veterinary medicine [301]. Their structure consists of an eight-membered heterocyclic system bearing one aromatic ring, a carboxylic acid and a ketone.…”

Section: Quinolonesmentioning

confidence: 99%

Current trends in sample preparation for growth promoter and veterinary drug residue analysis

Kinsella

O’Mahony

Malone

et al. 2009

Journal of Chromatography A

183

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A comprehensive review is presented on the current trends in sample preparation for isolation of veterinary drugs and growth promotors from foods. The objective of the review is to firstly give an overview of the sample preparation techniques that are applied in field. The review will focus on new techniques and technologies, which improve efficiency and coverage of residues. The underlying theme to the paper is the developments that have been made in multi-residue methods and particularly multi-class methods for residues of licensed animal health products, which have been developed in the last couple of years. The role of multi-class methods is discussed and how they can be accommodated in future residue surveillance.

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“…So, there is a need for a good and fast analytical procedure to accurately measure the concentration of levofloxacin in patients' blood. Different analytical methods such as capillary electro kinetic chromatography [13][14][15][16], solid phase spectrofluorimetry [17], and high performance liquid chromatography with fluorescent or UV detection [18][19][20][21][22][23][24][25][26][27] have been developed to measure the levofloxacin concentrations in plasma, urine, bile, faeces and other biological fluids [28]. To our knowledge, so far only five studies [29][30][31][32][33] have quantified levofloxacin concentrations by LC-MS/MS; however, among these studies some studies measured levofloxacin in human urine [27], other studies used plasma samples but did not provide description on run time and the ones that did had a relatively long run time and sample preparation time.…”

Section: Introductionmentioning

confidence: 99%

Determination of levofloxacin in human serum using liquid chromatography tandem mass spectrometry

Ghimire¹,

Hateren²,

Vrubleuskaya³

et al. 2018

J Appl Bioanal

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A rapid liquid chromatography tandem-mass spectrometry method was developed for the determination of levofloxacin and its metabolite (desmethyl-levofloxacin) in human serum. Sample preparation was done using protein precipitation technique. Our method had a run time of 2.5 min and retention times of 1.6 min for all analytes. The standard curves were linear within the concentration range of 0.10 to 5.00 mg/L for levofloxacin and 0.10 to 4.99 mg/L for desmethyllevofloxacin; a correlation coefficient (R 2 ) of 0.999 and 0.998 respectively. The lower limit of quantification for both analytes was 0.10 mg/L. Within-day precision ranged from 1.4% and 2.4% for levofloxacin, 1.5% to 5% for desmethyl-levofloxacin and between-day precision ranged from 3.6% to 4.1% for levofloxacin and 0.0% to 3.3% for desmethyl-levofloxacin; whereas, accuracy ranged from 0.1% to 12.7% for levofloxacin and 0.2% to 15.6% for desmethyl-levofloxacin. This method could be a useful asset for routine therapeutic drug monitoring of levofloxacin in multi-drug resistant tuberculosis patients.

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Analysis of quinolone residues in edible animal products

Cited by 206 publications

References 90 publications

Development of a new method for analysis of Sudan dyes by pressurized CEC with amperometric detection

Development of a new method for analysis of Sudan dyes by pressurized CEC with amperometric detection

Current trends in sample preparation for growth promoter and veterinary drug residue analysis

Determination of levofloxacin in human serum using liquid chromatography tandem mass spectrometry

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