In various regions of the world, there is an urgent need to address energy challenges by accelerating the transformation of energy and industrial systems. The problem is quite complex in rapidly developing composite regions, with the necessity to coordinate the dynamic development of energy and industry in several heterogeneous subregions. Through a typical case study on the Beijing-Tianjin-Hebei (BTH) region, this study attempts to form a referable methodology for the coordinated development of energy and industry for the sustainable development of rapidly developing composite regions. The concept of an Integrated strategy of Sustainable development objectives, Decision-making systems, Operation systems, and Physical systems (I-SDOP) is proposed to describe the multilayer dynamics of complex energy and industrial systems. A five-step I-SDOP analysis is conducted to determine an integrated strategy for the coordinated development of energy and industry in the BTH region, based on the analysis of its sustainable development objectives, decision-making systems, operation systems, and physical systems. The results indicate the importance of innovation sources and extensive communications to promote market reform and engineering projects that fulfill the strong political wills and strategic plans of China's central government.