Analysis of retinal and optic nerve electrogenesis dynamics after vitrectomy for complicated catarct surgery

Kulikov, Alexey N.; Николаевич, Куликов Алексей; Sosnovskii, Sergei V.; Викторович, Сосновский Сергей; Nikolaenko, Evgeniya N.; Николаевна, Николаенко Евгения

doi:10.17816/ov11334-47

Cited by 3 publications

(3 citation statements)

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“…Вероятным объяснением снижения функции нейронов является депрессивное влияние ВЭ на формирование биоэлектрического ответа нейронов проксимальной сетчатки и зрительного нерва. В ранее проведённых нами исследованиях доказано обратимое достоверное снижение электрогенеза в раннем послеоперационном периоде на уровне фоторецепторов и биполярных клеток после ВЭ, выполненной по поводу макулярного разрыва, дислокации фрагментов ядра хрусталика вследствие компликационной факоэмульсификации [7]. По данным отечественной и зарубежной литературы, снижение функциональной активности нейронов сетчатки, в том числе её внутренних слоёв, объясняется наличием операционной травмы вследствие механического воздействия на сетчатку во время удаления патологических мембран [11].…”

Section: таблица 2 / Tableunclassified

“…Однако, несмотря на успешность хирургического лечения ВМТС, функциональные исходы после ВЭ нередко оказываются неудовлетворительными [5,6]. В ранее проведённых нами исследованиях, а также по данным других авторов, одна из возможных причин угнетения функционального состояния сетчатки заключается в воздействии комплекса неблагоприятных факторов ВЭ как физической (вибрационное воздействие наконечника витреотома на сетчатку, удаление мембран), так и химической (воздействие различных красителей, заменителей стекловидного тела) природы [7][8][9][10]. Безусловно, в акте зрения важны как анатомическая, так и функциональная сохранность всех звеньев зрительного нервного пути, поэтому изучение влияния ВЭ при ВМТС на функциональную активность сетчатки и зри тельного нерва с применением электрофизиологических методик представляет актуальную научную задачу.…”

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Retinal and optic nerve functional activity after vitrectomy for vitreomacular traction syndrome

Nikolaenko

Николаевна²,

Kulikov

et al. 2019

Ophthalmology Reports

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Background. Impacts of vitrectomy for vitreomacular traction syndrome on retinal and optic nerve functional activity are analyzed. Materials and methods. The electrophysiological monitoring was carried out before vitrectomy and on Days 1, 3, 7, 14, 30, 60, 180 after surgery in 59 patients (59 eyes). Patients were divided into three groups depending on the intraocular tamponade type: the first group air tamponade, the second group gas (C3F8) tamponade, the third group BSS (balanced salt solution). Results. A significant inhibition of the functional activity of neurons of internal layers of the retina and of the optic nerve was revealed on the Day 1 after surgery compared to baseline data (р 0.001). In groups I and III, the functional activity of inner layers of the retina and of the optic nerve restored twice as actively as that in the second group. Conclusions. Vitrectomy causes a reversible and significant inhibition of functional activity of retina and optic nerve. The duration of vitrectomy procedure is a significant negative factor determining the degree of depression of the functional activity of inner layers of the retina and of the optic nerve in the post-op period. The gas tamponade of the vitreous cavity with perfluoropropane-air mixture, compared to air and BSS tamponades, is a significant negative factor influencing the degree of functional activity inhibition of retina and optic nerve after surgery.

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Section: Introductionunclassified

Retinal and optic nerve functional activity after vitrectomy for vitreomacular traction syndrome

Nikolaenko

Николаевна²,

Kulikov

et al. 2019

Ophthalmology Reports

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“…В настоящее время электрофизиологические исследования, в частности метод электроретинографии, являются одним из объективных методов оценки функционального состояния сетчатки, в частности фоторецепторов, нейронов первого и второго порядка, а также отражают биохимические и функциональные нарушения [13][14][15][16][17].…”

Section: Introductionunclassified

The rabbits retina functional state after exposure to low-frequency ultrasound: electroretinogram indicators analysis

Vafiev

2022

Vestn. Ross. univ. družby nar., Ser. Med.

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Relevance. Currently, several groups of scientists are working on the implementation of low-frequency ultrasound in surgery of the retina and vitreous body. But there are not enough articles on the study of the functional activity of the retina when exposed to this type of energy. Electrophysiological research methods make it possible to analyze and evaluate the safety, effectiveness of surgical interventions, the effect of new drugs at the level of neurons and visual pathways. The electroretinography method makes it possible to record the bioelectrical activity of retinal neurons during light stimulation during dark and light adaptation. The aim of the study is to carry out a comparative analysis of the aand b-wave indices of the rabbit electroretinogram after experimental removal of the vitreous body using low-frequency ultrasound and mechanical action. Materials and Methods. Experiments were carried out in two groups of Chinchilla rabbits (n = 40). In the experimental group, surgery to remove the vitreous body was performed using low-frequency ultrasound, in the control group a fragmentator with guillotine mechanism was used. Before and after the surgery (1, 7, 14, 30 days) an electroretinogram was recorded, the parameters of the amplitude and latency of the aand b-waves were measured. Results and Discussion. In both groups, a sharp decrease in all parameters was observed on day 1. Later, on the 7th day, the dynamics of the latency of aand b-waves slightly decreased than the preoperative values. On the 14th day after the exposure, the amplitude and peak latency of the aand bwaves in both groups remained at the same level as on the 7th day. On the 30th day, the indicators increased, which indicates the restoration of the functions of photoreceptors and Mueller cells in both groups. There were no statistically significant differences between the study groups at all periods of the study. Conclusion. The use of low-frequency ultrasound for vitreous removal can be considered safe and has prospects for further development and application.

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The rabbits retina functional state after exposure to low-frequencyultrasound: electroretinogram indicators analysis

Vafiev¹

2022

Vestn. Ross. univ. družby nar., Ser. Med.

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Relevance. Currently, several groups of scientists are working on the implementation of low-frequency ultrasound in surgery of the retina and vitreous body. But there are not enough articles on the study of the functional activity of the retina when exposed to this type of energy. Electrophysiological research methods make it possible to analyze and evaluate the safety, effectiveness of surgical interventions, the effect of new drugs at the level of neurons and visual pathways. The electroretinography method makes it possible to record the bioelectrical activity of retinal neurons during light stimulation during dark and light adaptation. The aim of the study is to carry out a comparative analysis of the a- and b-wave indices of the rabbit electroretinogram after experimental removal of the vitreous body using low-frequency ultrasound and mechanical action. Materials and Methods. Experiments were carried out in two groups of Chinchilla rabbits (n = 40). In the experimental group, surgery to remove the vitreous body was performed using low-frequency ultrasound, in the control group a fragmentator with guillotine mechanism was used. Before and after the surgery (1, 7, 14, 30 days) an electroretinogram was recorded, the parameters of the amplitude and latency of the a- and b-waves were measured. Results and Discussion. In both groups, a sharp decrease in all parameters was observed on day 1. Later, on the 7th day, the dynamics of the latency of a- and b-waves slightly decreased than the preoperative values. On the 14th day after the exposure, the amplitude and peak latency of the a- and b-waves in both groups remained at the same level as on the 7th day. On the 30th day, the indicators increased, which indicates the restoration of the functions of photoreceptors and Mueller cells in both groups. There were no statistically significant differences between the study groups at all periods of the study. Conclusion. The use of low-frequency ultrasound for vitreous removal can be considered safe and has prospects for further development and application.

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Analysis of retinal and optic nerve electrogenesis dynamics after vitrectomy for complicated catarct surgery

Cited by 3 publications

References 8 publications

Retinal and optic nerve functional activity after vitrectomy for vitreomacular traction syndrome

Retinal and optic nerve functional activity after vitrectomy for vitreomacular traction syndrome

The rabbits retina functional state after exposure to low-frequency ultrasound: electroretinogram indicators analysis

The rabbits retina functional state after exposure to low-frequencyultrasound: electroretinogram indicators analysis

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