Analysis of risk factors for patients with early‐stage cervical cancer: A study of 374 patients

Abstract

AimThis study aimed to identify the postoperative histological features affecting the prognosis of patients with early‐stage cervical cancer who underwent open radical hysterectomy.MethodsThis retrospective study enrolled 374 patients with pT1a, 1b1 and 2a1 early‐stage cervical cancer who underwent open radical hysterectomy between 2001 and 2018. Survival outcomes were analyzed by Kaplan–Meier method and compared with log‐rank test. Using the Cox proportional hazards regression test, we conducted a multivariate analysis for disease‐free survival and overall survival.ResultsOthers histology, including other epithelial tumors and neuroendocrine tumors, had a significantly worse prognosis in both disease‐free survival and overall survival than those of squamous cell carcinoma and adenocarcinoma (hazard ratio, 4.37 and 11.76; P = 0.006 and P = 0.002, respectively), along with lymph node metastasis (hazard ratio, 2.99 and 7.03; P = 0.009 and P = 0.001, respectively).ConclusionOthers histology including adenosquamous carcinoma had a poor prognosis in early‐stage cervical cancer as with high‐risk factors.

Initial treatment for FIGO 2018 stage IIIC cervical cancer based on histological type: A 14‐year multicenter study

“…A principal type of CC is squamous cell carcinoma (SCC), diagnosed in 75%–80% of cases, followed by adenocarcinoma (AC) diagnosed in 20%–25% of cases; adenosquamous cell carcinoma (ASC) is a rare type of CC. Previous studies have reported inconsistent prognoses for these different types of CC, with similar outcomes reported in several studies, 11–21 while others have reported differences in prognosis 22–29 . In addition, various histological types of CC respond differently to initial treatment, which has an impact on prognosis 28,30–33 .…”

“…Previous studies have reported comparable prognoses of SCC and AC/ASC types of CC, 11–21 as well as for AC and ASC 21 . Recently, differences in oncological characteristics, including pathophysiology, epidemiology, patterns of tumor metastasis, and prognosis, have been reported between the different histological types of CC 22–29 . The presence or absence of LNM might influence the outcomes, with comparable prognoses for SCC and AC types of CC without LNM but with a worse prognosis for AC than SCC type with LNM 37,38 .…”

“…21 Recently, differences in oncological characteristics, including pathophysiology, epidemiology, patterns of tumor metastasis, and prognosis, have been reported between the different histological types of CC. [22][23][24][25][26][27][28][29] The presence or absence of LNM might influence the outcomes, with comparable prognoses for SCC and AC types of CC without LNM but with a worse prognosis for AC than SCC type with LNM. 37,38 In our study sample of 3762 patients with SCC and 325 with AC/ASC type of FIGO 2018 stage IIIC CC, both the 5-year OS and DFS were better for those with SCC, in alignment with the results of Nakanishi et al 37 and of Kodama et al 38 With regard to R-CT, chemotherapy included simultaneously with radiotherapy provides a sensitizing effect on radiotherapy which may further reduce the repair capacity of tumor cells.…”

“…Previous studies have reported inconsistent prognoses for these different types of CC, with similar outcomes reported in several studies, [11][12][13][14][15][16][17][18][19][20][21] while others have reported differences in prognosis. [22][23][24][25][26][27][28][29] In addition, various histological types of CC respond differently to initial treatment, which has an impact on prognosis. 28,[30][31][32][33] Consequently, the initial treatment for stage IIIC CC should be individualized and be specific to the histological type.…”

Machine learning to reveal an astute risk predictive framework for Gynecologic Cancer and its impact on women psychology: Bangladeshi perspective

“…Some previous studies also showed that neurodegenerative disease spurs on cervical and ovarian cancer [ 9 , 10 ]. National Cancer Institute summarizes that cervical tumor constitutes in the cervix, a body part associating with uterus and vagina [ 11 , 12 ] Human Papillomavirus (HPV) is the main reason behind cervical cancer [ 13 ] For the well-known impact of HPV on cervical cancer, an examination [ 14 ] was made which audits the articles based on the information on HPV and cervical cancer among Malaysian inhabitants before and after the usage of HPV antibody programs. In [ 15 ] a research has been conveyed a study where he found cervical slowly develops without showing any indication at the beginning seemingly hard to discover but can be noticed with respective pap tests.…”