Analysis of Risk Factors Predictive of Early Mortality and Urgent ERCP in Acute Cholangitis

Abstract

Acute cholangitis is a disease that presents with varying severity. We report a scoring system that can be used to identify patients at high risk of early mortality and those that may benefit from earlier ERCP.

Mortality Risk for Acute Cholangitis (MAC): A risk prediction model for in-hospital mortality in patients with acute cholangitis

“…Adequate management of acute cholangitis is essential for survival [21][22][23][24]. However, acute cholangitis manifests from a broad variety of causes and with varied severity.…”

Initial Report of Outpatient Management of Acute Cholangitis via ERCP

“…The mean duration from initial symptoms of cholangitis to ERCP in our study was 2.14 days (51 h), which correlates well with these prior studies. In addition, early antibiotic administration is an important adjunct therapy in patients presenting with cholangitis, which all of our patients received at the time of presentation [5].…”

Management of acute cholecystitis and acute cholangitis in emergency setting

“…Gigot selected seven predictors of mortality in acute cholangitis -acute renal failure, associated liver abscesses, high malignant biliary stricture, liver cirrhosis, age and female gender-from a statistical analysis of 140 parameters in 449 acute attacks [86]. In a recent study of 108 patients, total bilirubin, partial prothrombin time and associated liver abscess were identified as predictors of mortality for acute cholangitis [87]. Most of these predictors for mortality in acute cholangitis are the criteria for severe grade III acute cholangitis.…”