Analysis of Salivary Antioxidant Levels in Different Clinical Staging and Histological Grading of Oral Squamous Cell Carcinoma: Noninvasive Technique in Dentistry

Singh, Hanspal; Shetty, Pushparaja; Patidar, Madhvika

doi:10.7860/jcdr/2014/9119.4670

Cited by 10 publications

(13 citation statements)

References 18 publications

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“…22 A decreased level of Salivary uric acid was observed by Hanspal Sing et al is OSCCA patients compared to controls and among patients a progressive decrease was seen in well to moderately and poorly differentiated tumors. 23 …”

Section: Discussionmentioning

confidence: 99%

Impact of age at diagnosis on clinicopathological outcomes of oral squamous cell carcinoma patients in Karachi

Mahmood¹,

Hanif²,

Ahmed³

et al. 2018

Pak J Med Sci

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Objective:A recent trend in diagnosis of oral cancer in young age is observed, however its impact on various clinicopathological parameters needs to be explored. The aim of the current study was to compare and analyze impact of age at diagnosis with clinicopathological parameters of oral squamous cell carcinoma patients.Methods:In this cross sectional study conducted at Department of Oncology Ziauddin Hospital Karachi, we included histologically confirmed cases of oral squamous cell carcinoma. The patients were categorized as young age group (40yrs and younger) and old age group (41 yrs and above). A total of 115 patients diagnosed between 2013 and 2016 were enrolled in the study. The variables considered were age at diagnosis, sex, site of lesion, positive family history, tumor grade, stage, uric acid level and survival.Results:A statistically significant difference was observed between two age groups in overall survival, uric acid level and positive family history of cancer. No significant difference was observed in tumor location, grade and stage.Conclusion:Majority of oral cancer patients present at an advanced stage irrespective of age at diagnosis but young age has an overall improved survival. Moreover, a positive family history of cancer in young age group mandates further exploration of possible role of genetic polymorphisms which might be responsible for early onset of the disease.

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Section: Discussionmentioning

confidence: 99%

Impact of age at diagnosis on clinicopathological outcomes of oral squamous cell carcinoma patients in Karachi

Mahmood¹,

Hanif²,

Ahmed³

et al. 2018

Pak J Med Sci

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“…However, questions remain regarding the roles of salivary proteins, especially histatin, in ROS generation and oxidative stress in the oral cavity. Few studies have investigated the antioxidant effects of salivary proteins by measuring SOD level (36,37) or lipid peroxidation. (38) While the effect of copper-mediated oxidation of histatin 8 on the generation of HO • , as evaluated by electron spin resonance (ESR), has been reported, (39) the direct effects of histatin on ROS generation have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Direct assessment of the antioxidant property of salivary histatin

Komatsu

Kobayashi

Helmerhorst

et al. 2019

J. Clin. Biochem. Nutr.

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Histatin, a salivary protein, affects oral homeostasis through preservation of tooth integrity and protection against caries and fungal infections. However, the effects of histatin in the generation of oxidative stress induced by reactive oxygen species and in the oral cavity remain unclear. In this study, the effects of histatin on direct reactive oxygen species scavenging activity were examined using electron spin resonance. We demonstrated, for the first time, that histatin exhibits antioxidant activity against hydroxyl radicals generated by Fenton’s reaction by metal chelation or binding. The direct antioxidant effects of histatin, along with its antimicrobial activity, may be important in the oral protection of salivary proteins.

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“…In another study, Singh et al [ 33 ] in India compared the salivary antioxidant level of uric acid, glutathione S transferase, and superoxide dismutase between healthy controls and OSCC patients. Also, they compared the study subgroups based on clinical stage and histopathological grade of cancer.…”

Section: Discussionmentioning

confidence: 99%

Role of Serum Uric Acid as a Protective Biomarker in Patients with Different Histopathological Grades of Oral Squamous Cell Carcinoma: a Case-Control Study

Manifar

Rahimzamani

Shirkhoda

et al. 2020

BioMed Research International

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The antioxidant properties of uric acid may have a protective effect against the formation of oxygen radicals and subsequently against carcinogenicity. The present study aimed at evaluating the serum level of uric acid in patients with oral squamous cell carcinoma (OSCC) with different histopathological grades. In this descriptive-analytical, case-control study, patients with OSCC and healthy controls were selected and matched regarding age and gender. The serum samples were collected from patients (before radiotherapy and chemotherapy) and controls, and their serum uric acid levels were measured enzymatically. Data were analyzed using independent t-test and ANOVA at 0.05 level of significance. The mean serum uric acid level in OSCC patients (4.2±1.5 mg/dL) and healthy controls (4.38±1.22 mg/dL) was not significantly different (P=0.377). No significant association was noted between the histopathological grade of OSCC and mean serum uric acid (P=0.781). The serum uric acid level had a direct significant correlation with age in OSCC patients (P<0.001). The results of this study did not support the role of uric acid as a protective biomarker in OSCC. Further prospective studies are recommended to better elucidate the role of uric acid in the etiology of OSCC.

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Analysis of Salivary Antioxidant Levels in Different Clinical Staging and Histological Grading of Oral Squamous Cell Carcinoma: Noninvasive Technique in Dentistry

Cited by 10 publications

References 18 publications

Impact of age at diagnosis on clinicopathological outcomes of oral squamous cell carcinoma patients in Karachi

Impact of age at diagnosis on clinicopathological outcomes of oral squamous cell carcinoma patients in Karachi

Direct assessment of the antioxidant property of salivary histatin

Role of Serum Uric Acid as a Protective Biomarker in Patients with Different Histopathological Grades of Oral Squamous Cell Carcinoma: a Case-Control Study

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