Analysis of seroprevalence and risk factors for hepatitis E virus (HEV) in donation candidates and blood donors in Northeast Brazil

Cunha, Gabriel Galindo; Bezerra, Luan Araújo; Júnior, José Valter Joaquim Silva; Gonçales, Juliana Prado; Montreuil, Ana Cristina Bezerra; Coêlho, Maria Rosângela Cunha Duarte

doi:10.1007/s42770-022-00816-z

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…Hardtke et al [ 78 ] reported similarly high anti-HEV prevalence in pregnant women (19%) and female blood donors from Curitiba (PR), using cryopreserved samples obtained in 2002–2003. These data contrast with the low prevalence in blood donors from the Northeast (0.9%) [ 84 ] and North (0.4%) [ 71 ] ( Table 1 ), demonstrating a paradigm shift of the binomial poverty−higher risk of HEV infection in developing countries. As a matter of fact, the estimated anti-HEV prevalence in the USA, a high-income country with a 0.92 HDI (human development index), was significantly higher than in Brazil (HDI 0.76) and other poorer South American countries with suboptimal hygiene and sanitation conditions [ 103 ].…”

Section: Hev Prevalence In the Brazilian Populationmentioning

confidence: 83%

Hepatitis E Virus Research in Brazil: Looking Back and Forwards

Oliveira

Santos

Pinto

2023

Viruses

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Hepatitis E virus (HEV) has emerged as a public health concern in Brazil. From the first identification and characterization of porcine and human HEV-3 strains in the 2000s, new HEV subtypes have been identified from animal, human, and environmental isolates. As new potential animal reservoirs have emerged, there is a need to compile evidence on the zoonotic dissemination of the virus in animal hosts and the environment. The increasing amount of seroprevalence data on sampled and randomly selected populations must be systematically retrieved, interpreted, and considered under the One Health concept. This review focused on HEV seroprevalence data in distinct animal reservoirs and human populations reported in the last two decades. Furthermore, the expertise with experimental infection models using non-human primates may provide new insights into HEV pathogenesis, prevention, and environmental surveillance.

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