Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China

Ding, Xiaohu; Jiang, Meng; Jing, Hao; Wei, Sheng; Wang, Xingwen; Han, Jianyong; Wang, Lühua

doi:10.1007/s11356-014-3970-9

Cited by 70 publications

(51 citation statements)

References 25 publications

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“…In women with BC, the trace elements, cadmium, magnesium, copper, cobalt and lithium, were found in high levels. This suggests a possible association between serum levels of trace elements and breast cancer risk, however, this requires further investigation and if confirmed, the modulation of trace elements may help to reduce breast cancer risk (Ding et al, 2015).…”

Section: Dietary Factorsmentioning

confidence: 99%

“…Dietary factors associated with increased BC risk included intake of total n-6 polyunsaturated fatty acids (PUFA) (Kiyabu et al, 2015), vitamin D deficiency or insufficiency (Shi et al, 2014a;Park et al, 2015a), high levels of serum cadmium (Nagata et al, 2013;Itoh et al, 2014;Ding et al, 2015), high intake of salt (Park et al, 2014b), sugar (Sulaiman et al, 2014), meat (Ko et al, 2013), and saturated fat and oils (Balasubramaniam et al, 2013;Wang et al, 2013a). In women with BC, the trace elements, cadmium, magnesium, copper, cobalt and lithium, were found in high levels.…”

Section: Dietary Factorsmentioning

confidence: 99%

“…High intake of dietary fiber was associated with decreased BC risk (Sulaiman et al, 2014) along with high levels of α-carotene, β-carotene, β-cryptoxanthin, lutein/ zeaxanthin (Wang et al, 2014a), and soy products or isoflavones (Ko et al, 2013;Li et al, 2013a;Wada et al, 2014) (Table 2). In addition, BC patients had significantly lower levels of manganese, aluminum, iron and titanium than women who did not have BC (Ding et al, 2015). High consumption of fruit and vegetables has also been linked to a reduction in breast cancer risk in Asia.…”

Section: Dietary Factorsmentioning

confidence: 99%

See 2 more Smart Citations

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Youn

Han

2020

Asian Pac J Cancer Prev

105

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Background and Aim: Breast cancer is the most prevalent cancer in women. To date, regional differences in breast cancer risk factors have not been identified. The aim of our review was to gain a better understanding of the role of risk factors in women with breast cancer in Asia. Methods: We conducted a PubMed search on 15 March 2016, for journal articles published in English between 2011 and 2016, which reported data for human subjects in Asia with a diagnosis of breast cancer. Search terms included breast neoplasm, epidemiology, Asia, prevalence, incidence, risk and cost of illness. Studies of any design were included, except for review articles and meta-analyses, which were excluded to avoid duplication of data. No exclusions were made based on breast cancer treatment. We reported the results using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Results: A total of 776 abstracts were retrieved. After screening against the eligibility criteria, 562 abstracts were excluded. The remaining 214 abstracts, which were published between 2013 and 2015, were included in this review. Results were summarized and reported under three categories: incidence, prevalence or outcomes for breast cancer in Asia; modifiable risk factors; and non-modifiable risk factors. We found that the increased risk of breast cancer among participants from Asia was associated with older age, family history of breast cancer, early menarche, late menopause, high body mass index, being obese or overweight, exposure to tobacco smoke, and high dietary intake of fats or fatty foods. In contrast, intake of dietary fruits, vegetables, and plant-and soy-based products was associated with a decreased breast cancer risk. While based on limited data, when compared to women from the United States, women from Asia had a decreased risk of breast cancer. Conclusions: This review of 214 abstracts of studies in Asia, published between 2013 and 2015, confirmed the relevance of known non-modifiable and modifiable risk factors for women with breast cancer.

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Section: Dietary Factorsmentioning

confidence: 99%

Section: Dietary Factorsmentioning

confidence: 99%

Section: Dietary Factorsmentioning

confidence: 99%

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A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Youn

Han

2020

Asian Pac J Cancer Prev

105

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“…Some risk factors including early menarche, late menopause occurred, body mass index (BMI) and obesity after menopause, estrogen intake, alcohol consumption and tobacco use, exposure to ionizing radiation, and eating habits (3), as well as genetic (4)(5)(6), environmental factors (5,6), and ethnicity (7) can effect on the incidence of BC. In various studies, it was found that the serum levels of trace elements in patients with BC have changed and although their role is not fully understood, it may be associated with the risk of this disease (8). Zinc (Zn) is a vital mineral for the operation of numerous cellular processes and growth and may play an important role in malignancy etiology and outcome (9).…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Selenium and Zinc in Patients with Breast Cancer: A Case-Control Study

et al. 2017

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Background: Zinc (Zn) and Selenium (Se) are trace minerals that have high anti-cancer and chemopreventive properties. Objectives: This study aimed at evaluating the serum levels of both elements in women with breast cancer (BC) compared with control group and the correlation of them with risk factors of BC. Methods: In a case-control study, 142 women with BC and 158 healthy controls, aged 19 to 88 years, were selected. Both groups did not use any type of supplement 3 months before participation in the study; there was no history of chronic kidney or liver disease or malabsorption disorders among the participants and body mass index was between 18.5 and 30 based on Quetelet index. The Se by graphite furnace and Zn by flame were atomized and the amount of each of 2 elements was measured and recorded by the Absorption device.

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“…Recently Larner et al have studied the isotopic compositions of Zn in breast cancer tissues and observed that breast cancer tumors are found to have a significantly lighter isotopic distribution of Zn than in blood, serum, and healthy breast tissues. Ding et al have analyzed the concentration levels of 15 trace elements such as Zn, Mn, Al, Cd, Fe, Mg, Ca, Pb, Cu, Se, Ni, Ti, Co, Li, and Cr in breast cancer patients in Shandong of China. They have observed that breast cancer patients have significantly higher serum levels of Cd, Mg, Cu, Co, and Li and significantly lower serum levels of Mn, Al, Fe, and Ti compared with their matched controls.…”

Section: Introductionmentioning

confidence: 99%

Determination of trace elements in normal and malignant breast tissues of different age group using total reflection X‐ray fluorescence spectrometer

Mirji

Badiger²,

Sanyal

et al. 2018

X-Ray Spectrometry

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The trace elements in normal and malignant breast tissues of different age groups have been determined using total reflection X‐ray fluorescence (TXRF) spectrometry. The low Z elements are detected using a vacuum chamber of low Z–high Z (WOBISTRAX) TXRF spectrometer and medium and high Z elements using Ital structures TX‐2000 TXRF spectrometers. The trace elements such as Al, P, S, Cl, K, Ca, Ti, Fe, Cu, Zn, Br, Sr, and Y have been detected in normal and malignant breast tissues in the age group 31–40, 41–50, 51–60, and 61–70 years. It is found that the concentration of trace elements such as Al and Ti, Cu and Zn, Ti and Br, and Al and Y are higher in normal breast tissues than in the malignant breast tissues in the samples of age group 31–40, 41–50, 51–60, and 61–70 years, respectively. It is very important to note that the trace element Pb is not observed in the samples of age group 31–40, 41–50, and 51–60, but it has been observed in the samples of age group 61–70 years. Trace elements in normal and malignant tissues measured using TXRF spectrometers. Tissues of different age group have been selected to ascertain the role of trace elements. Trace elements P, S, Cl, K, Ca, Fe, and Sr are found to be higher in malignant tissues. Trace element Pb is found to be higher in malignant tissues in the age group 61–70.

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Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China

Cited by 70 publications

References 25 publications

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Serum Levels of Selenium and Zinc in Patients with Breast Cancer: A Case-Control Study

Determination of trace elements in normal and malignant breast tissues of different age group using total reflection X‐ray fluorescence spectrometer

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