Analysis of Serum Proteins and Enzymes Level in Human Subjects with Osteoarthritis

Ahmad, Aqil; Irshad, Mohd; Ahmad, Waseem; Khan, Abdul Hakim; Ahmad, Riaz

doi:10.2478/v10011-010-0045-4

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…Obesity has been associated with low serum le vels of vitamin D. The logic explanation for such an observation is probably the life style of the individuals with BMI >25 (sedentary, indoors, not expo sed to sunlight in order to hide the overweight). Besides, there is the fact that vitamin D is a fat-so luble vitamin that is taken up by adipose tissues (42)(43)(44)(45)(46).…”

Section: Vitamin D Deficiency and The Risk Of Developing Sarcoidosismentioning

confidence: 99%

The role of vitamin D in multisystem sarcoidosis / Uloga vitamina D u sarkoidozi

Mihailović-Vučinić¹,

Ignjatović²,

Dudvarski-Ilić³

et al. 2012

Journal of Medical Biochemistry

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Summary: Recently published data indicate that vitamin D abnormalities are common in sarcoidosis patients. The purpose of this study was to compare serum vitamin 25(OH)D levels among sarcoidosis patients with different clinical courses of the disease. The study also included the first observations on cognitive functions (i.e. depression and fatigue syndrome) in relation to vitamin D deficiency in sarcoidosis patients. At the Biochemical Laboratory of the Clinical Center of Serbia, Belgrade, vitamin D25(OH)D was measured using the Elecsys ® Vitamin D total test. A total of 226 patients with biopsy-positive sarcoidosis were analyzed. The average median value of serum vitamin D was 9.47 mg/L, suggesting severe deficiency. Statistically significant correlation was found in patients with chronic disease and low levels of serum vitamin 25(OH)D (Chi-Square=6.044; df=2; p=0.014). The patient group with vitamin D serum levels higher than 20 mg/L showed higher levels of the mean forced vi tal capacity (FVC) by 380 mL, and forced expiratory volume in one second (FEV1) by 220 mL, when compared to the patient group with lower serum vitamin D. A statistically significant role was established for serum vitamin 25(OH)D levels as the predictor of fatigue (R 2 =0.878; p=0.038 (b=0.216)) and depression in patients with sarcoidosis (R 2 =0.80; p=0.000 (b=0.391)). The insufficiency of 25(OH)D seems to be an important factor in predicting the course of chronic disease, significant lung function impairments and cognitive failures such as fatigue and depression. The fact that the majo rity of the analyzed sarcoidosis patients had totally deficient serum 25(OH)D levels made this finding even more notable. Keywords: vitamin D, deficiency, sarcoidosisKratak sadr`aj: Nedavno objavljena istra`ivanja kod obole lih od sarkoidoze govore o ~estim abnormalnim vrednostima vitamina D. Cilj ove studije bio je da se uporedi nivo vita mina 25(OH)D kod obolelih od sarkoidoze sa razli~itim klini~kim tokom bolesti. Tako|e, ova studija predstavlja prva za pa `anja o vezi izme|u kognitivnih funkcija (odnosno ose}a ja depresije i zamora) i deficita vitamina D kod obolelih od sarko idoze. U Biohemijskoj laboratoriji Klini~kog centra Srbije vitamin D -25(OH)D meren je kori{}enjem testa Elec sys ® Vitamin D. Analizirano je 226 bolesnika sa sarkoidozom potvr|enom biopsijom. Prose~na srednja vrednost vitamina D u serumu bila je 9,47 mg/L, {to ukazuje na ozbiljan nedostatak. Statisti~ki zna~ajna korelacija na |e na je kod pa cije nata sa hroni~nom formom bolesti i niskim nivoom vitamina 25(OH)D u serumu (Xi-kvad rat=6,044; df=2; p=0,014). Grupa pacijenata sa nivoom vitamina D u serumu ve}im od 20 mg/L pokazuje ve}i nivo srednjeg for siranog vitalnog kapaciteta (FVC) za 380 mL i forsiranog ekspi ratornog volumena u prvoj sekundi (FEV1) za 220 mL u od nosu na grupu pacijenata sa ni`im nivoom D vitamina. Utvr|eno je da nivo vitamina 25(OH)D u serumu ima stati sti~ki zna~ajnu ulogu kao prediktor zamora i depresije kod obolelih od sarkoidoze. Insuficijencija 25(OH)D ...

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Section: Vitamin D Deficiency and The Risk Of Developing Sarcoidosismentioning

confidence: 99%

The role of vitamin D in multisystem sarcoidosis / Uloga vitamina D u sarkoidozi

Mihailović-Vučinić¹,

Ignjatović²,

Dudvarski-Ilić³

et al. 2012

Journal of Medical Biochemistry

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“…Apart from the MMPs, esterase is detected in the synovial fluid of OA patients. [75][76][77] Since the ester bonds present in TG-18 are susceptible to esterase and MMPs, we used it to achieve sustained release of BI-4394. 51 To investigate the release of the encapsulated BI-4394 in response to the enzymes, Gel@5 and Gel@10 were placed in dialysis bags containing 100 U mL À1 esterase.…”

Section: Rheologymentioning

confidence: 99%

On-demand release of a selective MMP-13 blocker from an enzyme-responsive injectable hydrogel protects cartilage from degenerative progression in osteoarthritis

Roy,

Murugesan,

Kulkarni

et al. 2024

J. Mater. Chem. B

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“…Obesity has been associated with low ser um le vels of vitamin D. The logic explanation for such an obser vation is probably the life style of the individuals with BMI >25 (sedentary, indoors, not expo sed to sunlight in order to hide the overweight). Besides, there is the fact that vitamin D is a fat-so luble vitamin that is taken up by adipose tissues (42)(43)(44)(45)(46).…”

Section: Vitamin D Deficiency and The Risk Of Developing Sarcoidosismentioning

confidence: 99%

THE role of vitamin D in multisystem sarcoidosis

Mihailović-Vučinić¹,

Videnović-Ivanov²,

Filipović³

et al. 2012

Pneumologie

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Recently published data indicate that vitamin D abnormalities are common in sar coidosis patients. The purpose of this study was to compar e serum vitamin 25(OH)D levels among sarcoidosis patients with differ ent clinical courses of the disease. The study also included the first obser vations on cognitive functions (i.e. depr ession and fatigue syndrome) in r elation to vitamin D deficiency in sar coidosis patients. At the Biochemical Laboratory of the Clinical Center of Serbia, Belgrade, vitamin D25(OH)D was measur ed using the Elecsys ® Vitamin D total test. A total of 226 patients with biopsy-positive sarcoidosis were analyzed. The average median value of ser um vitamin D was 9.47 mg/L, suggesting severe deficiency. Statistically significant cor relation was found in patients with chronic disease and low levels of serum vitamin 25(OH)D (Chi-Squar e=6.044; df=2; p=0.014). The patient group with vitamin D serum levels higher than 20 mg/L showed higher levels of the mean for ced vi tal capacity (FVC) by 380 mL, and for ced expiratory volume in one second (FEV1) by 220 mL, when compared to the patient group with lower serum vitamin D. A statistically significant role was established for serum vitamin 25(OH)D levels as the pr edictor of fatigue (R 2 =0.878; p=0.038 (b=0.216)) and depression in patients with sar coidosis (R 2 =0.8 0; p=0.000 (b=0.391)). The insufficiency of 25(OH)D seems to be an important factor in pr edicting the course of chr onic disease, significant lung function impair ments and cognitive failur es such as fatigue and depr ession. The fact that the majo rity of the analyzed sarcoidosis patients had totally deficient ser um 25(OH)D levels made this finding even mor e notable.

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Analysis of Serum Proteins and Enzymes Level in Human Subjects with Osteoarthritis

Cited by 5 publications

References 43 publications

The role of vitamin D in multisystem sarcoidosis / Uloga vitamina D u sarkoidozi

The role of vitamin D in multisystem sarcoidosis / Uloga vitamina D u sarkoidozi

On-demand release of a selective MMP-13 blocker from an enzyme-responsive injectable hydrogel protects cartilage from degenerative progression in osteoarthritis

THE role of vitamin D in multisystem sarcoidosis

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