Abstract.A proton cyclotron MC-50 in Korea Institute of Radiological & Medical Science (KIRAMS) is used to carry out neutron activation experiments with Y 2 O 3 targets irradiated with neutron beams of a continuous spectrum produced by proton beams on a thick beryllium target. Neutrons are generated by 9 Be (p, n) reaction with an incident proton intensity of 20 µA. The neutron spectra generated by proton beams of 30, 35, and 40 MeV are calculated by GEANT4 simulations. Nb powders are used for neutron flux monitoring by measuring the activities of 92m Nb through the reaction 93 Nb (n, 2n). By using a subtraction method, the average cross section of 89 Y(n,2n) and 89 Y(n,3n) reactions at the neutron energies of 29.8 ± 1.8 MeV and 34.8 ± 1.8 MeV are extracted and are found to be close to the existing cross sections from the EXFOR data and the evaluated nuclear data libraries such as TENDL-2015 or EAF-2010.