Analysis of sister chromatid exchanges in lymphocytes cultured from 71 healthy men

Abstract

Sister chromatid exchanges (SCE) were analyzed in peripheral blood lymphocytes from a select group of 71 healthy men, 56 nonsmokers and 15 cigarette smokers. In addition to estimating baseline SCE, data were examined to seek relationships of SCE frequencies to age and smoking. The baseline value of 7.53 SCE per cell from the 56 nonsmokers was within the range (5.60 to 9.10 SCE/cell) reported for other human populations. No relationship was found between the mean SCE frequency per cell and age. However, a significant increase in the SCE mean value was observed in smokers as compared to nonsmokers. The results of this study are compared with those of other reports on SCE effects of age and smoking.

Spontaneous sister chromatid exchange in mitotic chromosomes of the chinchilla (Chinchilla lanigera)

“…Age significantly affects the incidence of SCE. Older animals develop more SCEs per cell compared with younger animals (Sinha et al 1985;Lazutka et al 1994;Peretti et al 2006;Husum et al 2008;Wnuk et al 2011;Wo´jcik et al 2011), and differences in the numbers of SCEs between old and young chinchillas were also observed in the present study. We observed a highly interesting interrelationship.…”

Sister chromatid exchange in selected horse breeds (<i>Equus caballus</i>)

“…In the older animals the frequency of SCEs was much higher. Such correlation was also observed in humans (Sinha et al 1985, Lazutka et al 1994, Husum et al 1986. Our own studies revealed that the age was a significant factor affecting the number of SCEs.…”

The Effect of Environmental Factors on Sister Chromatid Exchange Incidence in Domestic Horse (Equus caballus) Chromosomes

“…SCE incidence is affected by the age of animals. Older animals tend to have increasingly more SCEs (SINHA et al 1985;LAZUTKA et al 1994;PERETTI et al 2006;HUSUM et al 2008). Our study confirmed this regularity.…”