Analysis of some antispasmodic drugs: oxyphencyclimine and glycopyrronium bromide

Ebeid, Mohamed; Moussa, Bahia Abbas; Malak, Aida A. Abdel

doi:10.1007/bf01960069

Cited by 6 publications

(2 citation statements)

References 2 publications

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“…Reviewing the literature survey, several methods were carried out for estimation of formoterol fumarate including spectrophotometry [6, 7], ultra performance liquid chromatography (UPLC) [8], gas chromatography mass spectrometric method (GC–MS) [9, 10], liquid chromatography [11–18], capillary electrophoresis [19–21]. Regarding, glycopyrronium bromide, few methods were described, including: UV [22, 23], conductometry [24], classical GC [25], HPLC [26–29], and advanced HPLC–MS methods [30, 31].…”

Section: Introductionmentioning

confidence: 99%

Multiple analytical methods for determination of formoterol and glycopyrronium simultaneously in their novel combined metered dose inhaler

et al. 2019

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One of the major causes of mortality all over the world is chronic obstructive pulmonary disease (COPD). Recently approved combined inhaler of formoterol fumarate (FF) and glycopyrronium bromide (GLY) has been used in very low concentrations (µg level/actuation) doses in COPD patients. The first spectrophotometric and advanced highly sensitive liquid chromatography has been achieved successfully throughout this study, permitting validated analysis of dual combined inhaler in raw material as well as pharmaceutical inhaled dosage form. Three sensitive analytical methods were carried out for the simultaneous assay of FF and GLY in their novel combined Metered dose inhaler (MDI). The first method depends on measuring the first derivative amplitudes at 208.27 nm for FF and at 213.27 nm and 239.86 nm for GLY, respectively. The second method depends on measurement of the first derivative of the ratio spectra at 214 or 229 nm for FF and 240 or 259 nm for GLY, respectively. For the spectrophotometric methods, the linearity ranges were 0.48–9.6 µg/mL for FF and 0.9–18 µg/mL for GLY. For the third method, valid ion-pairing chromatographic method was carried out applying C 18 column and isocratic mobile phase of 60% v/v acetonitrile and 40% v/v deionized waster (pH 3.0) enclosing 0.025% sodium dodecyl sulfate, using UV detection adjusted to 210 nm and flow rate of 1.2 mL/min. For the ion-pairing chromatographic method, the linearity ranges were 0.048–4.8 µg/mL for FF and 0.09–9.0 µg/mL for GLY. The developed methods are reproducible, valid and offer efficient resolution between formoterol and glycopyrronium using spectrophotometric methods and highly sensitive and precise chromatographic method. The percent recoveries of the inhaled drugs in their MDI were good. The method was successfully established for the quantitative analysis of FF and GLY in their combined pharmaceutical inhaler capsules to validate the therapeutic efficiency of the combined drugs in quality control labs. Electronic supplementary material The online version of this article (10.1186/s13065-019-0592-9) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Multiple analytical methods for determination of formoterol and glycopyrronium simultaneously in their novel combined metered dose inhaler

et al. 2019

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“…It's a white, nonhygroscopic powder, freely soluble in water, soluble in methanol (96%), very slightly soluble in methylene chloride (O'Neil, 2013). Ultibro ® Breezhaler is a combination of indacaterol maleate and glycopyrronium bromide licensed as a maintenance bronchodilator treatment to treat chronic obstructive pulmonary disease in which indacaterol maleate is long acting β 2 agonist and glycopyrronium bromide is long acting antimuscarinic (Frampton, 2014) .There is a few reported spectrophotometric method for simultaneous determination of indacaterol maleate and glycopyrronium bromide (Maha et al, 2016& Jaya et al, 2017 .Literature survey revealed that different methods for determination of glycopyrronium bromide in biological fluids using LC-MS (Matassa et al ,1992& Storme et al ,2008 HPLC (Venkateshwaran et al, 1995), GC (Murray et al,1984),visible spectrophotometric method (Ebeid et al, 1986 ).The objective of the present work is to design and prepare three ion selective electrodes, PVC, coated graphite and modified carbon paste sensors for determination of glycopyrronium bromide in bulk powder and pharmaceutical preparation.…”

Section: Introductionmentioning

confidence: 99%

Potentiometric Determination of Glycopyrronium Bromide in Binary Mixture With Indacaterol Maleate Using Polyvinyl Chloride (Pvc) Membrane, Coated Graphite and Carbon Paste Sensors

Dosoky

2018

Al-Azhar Journal of Pharmaceutical Sciences

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A novel approach was conducted in this article for the determination of glycopyrronium bromide (GLY) in binary mixture with indacaterol maleate using ion selective electrodes for its selective determination in pure form and pharmaceutical formulation. Four ion selective electrode sensors were designed for determination of glycopyrronium bromide namely; glycopyrronium bromide-polyvinyl chloride (GLY-PVC) membrane, GLY-Coated graphite sensor and GLY-modified carbon paste sensors. The sensors are based on the ion association complexes of GLY cation with sodium tetra phenyl borate (GLY-TPB) and phosphomolybidic acid (GLY-PMA) counter anions as ion exchange sites using dioctylphthalate (DOP) as plasticizer. Validation of the method shows suitability of the proposed sensors for use in the quality control assessment of GLY and for its routine analysis. The results obtained were statistically compared to reported method and there was no significant difference between the proposed methods and the reported method regarding the accuracy and precision. The method was validated according to International Conference on Harmonization (ICH) guidelines and the results were satisfactory.

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High hydrostatic pressure pretreated fermented apple juice attenuated anaphylaxis by improving gut microbiota and metabolic regulation

Ma,

Zhang,

Ren

et al. 2025

Food Bioscience

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Analysis of some antispasmodic drugs: oxyphencyclimine and glycopyrronium bromide

Cited by 6 publications

References 2 publications

Multiple analytical methods for determination of formoterol and glycopyrronium simultaneously in their novel combined metered dose inhaler

Multiple analytical methods for determination of formoterol and glycopyrronium simultaneously in their novel combined metered dose inhaler

Potentiometric Determination of Glycopyrronium Bromide in Binary Mixture With Indacaterol Maleate Using Polyvinyl Chloride (Pvc) Membrane, Coated Graphite and Carbon Paste Sensors

High hydrostatic pressure pretreated fermented apple juice attenuated anaphylaxis by improving gut microbiota and metabolic regulation

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