Analysis of some industrial metals and ions in the cerebral cortex of goats in Nigeria

Olopade, J. O.; Onwuka, SK; Adejumo, D. O.; Ladokun, AA

doi:10.4314/nvj.v26i2.3492

Cited by 6 publications

(10 citation statements)

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“…Increased exploitation of minerals has led to pollution of confined environments ( Igado et al, 2008 , Olopade et al, 2005 ), as documented in the Niger Delta in Nigeria ( Usende et al, 2016 , Usende et al, 2017 , Usende et al, 2020 , Usende et al, 2022 ). Air pollution which is a complex mixture of gases, metals, indoor and outdoor organic compounds, endotoxins and particulate matter is associated with adverse health effects ( Calderon-Garciduenas et al, 2001 , Calderon-Garciduenas et al, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Neuroecotoxicology: Effects of environmental heavy metal exposure on the brain of African giant rats and the contribution of vanadium to the neuropathology

Usende¹,

Olopade²,

Azeez³

et al. 2022

IBRO Neuroscience Reports

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Section: Introductionmentioning

confidence: 99%

Neuroecotoxicology: Effects of environmental heavy metal exposure on the brain of African giant rats and the contribution of vanadium to the neuropathology

Usende¹,

Olopade²,

Azeez³

et al. 2022

IBRO Neuroscience Reports

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“…The human population has been on a steady increase in third world countries [1] , resulting in destructive human activities such as increased exploitation of minerals leading to pollution of confined environments [1] , [2] .…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress changes observed in selected organs of African giant rats (Cricetomys gambianus) exposed to sodium metavanadate

Usende

Olopade

Emikpe

et al. 2018

International Journal of Veterinary Science and Medicine

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Vanadium is a contaminant of crude oil that released into the atmosphere through burning of fossil fuels. The mechanism by which it exerts toxic influences had not been fully elucidated in African giant rat (AGR). This study investigates the mechanisms of sodium metavanadate (SMV) induced oxidative stress in AGR. A total of 24 adult male AGR weighing 600–850 g were used. Animals were randomly divided into six groups. Groups 1, 3 and 5 served as control while groups 2, 4 and 6 were treated with intraperitoneal 3 mg/kg body weight of SMV for 3, 7 and 14 days, respectively. Serum, brain, liver, testes, kidneys, spleen and lungs were harvested for biochemical assays. SMV induced significant increase in malondialdehyde, hydrogen peroxide, sulfhydryl (total thiol) and protein carbonyl levels but decreased non-protein thiol levels in tissues accessed. A significant decrease was observed in glutathione-S-transferase (GST), superoxide dismutase (SOD), reduced glutathione (GSH) and glutathione peroxidase (GPx) levels in SMV treated rats compared to controls. Serum myeloperoxidase, xanthine oxidase and Advanced Oxidative Protein Products (AOPP) were markedly increased while nitrous oxide levels were significantly decreased in all treated groups. SMV exposure to AGR induced oxidative stress through generation of reactive oxygen species (ROS) and depletion of the antioxidant defence system. These conditions could become severe with prolonged exposure.

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“…Environmental pollution in third world countries has been on the increase for the past ve decades due to increased exploration of minerals (Calderon-Garciduenas et al, 2003;Olopade et al, 2005;Usende et al, 2016). Metals such as vanadium are emitted as a result of this constant increase of environmental pollution mainly due to combustion of fossil fuel (Calderon-Garciduenas et al, 2003;Igado et al, 2008;Usende et al, 2016Usende et al, , 2017.…”

Section: Introductionmentioning

confidence: 99%

Reproductive Hormones Imbalance, Germ Cell Apoptosis, Abnormal Sperm Morphophenotypes and Ultrastructural Changes in Testis of African Giant Rats (Cricetomys gambianus, Waterhouse, 1840) Exposed to Sodium Metavanadate Intoxication

Usende

Oyelowo

Adikpe

et al. 2021

Preprint

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Environmental exposure to vanadium has been on the increase in recent time. This metal is a known toxicant. The current study was conducted to investigate the reproductive toxicity of sodium metavanadate (SMV) in male African giant rats. Administration of SMV was done intraperitoneally daily for 14 consecutive days at a dosage of 3mg/kg body weight. Sterile water was administered to the control group. We analyzed serum reproductive hormones, sperm reserve and quality as well as testicular ultrastructural changes following SMV treatment. Our results showed SMV exposed AGR group had statistically increased progesterone but decreased testosterone, FSH and LH concentrations. Also, SMV treated group had statistically decreased sperm motility and mass activity with increased percentage of abnormal morphophenotypes of spermatozoa and upregulation of P53 immunopositive cell. Ultrastructural study revealed vocuolation of germ and Sertoli cells, cytoplasmic and nucleus; and mitochondrial swelling and vacuolations were also observed. There was severe disintegration of the seminiferous tubules, atrophy and degeneration of myeloid cells and apoptosis of the Leydig, Sertoli and germ cells. In conclusion, intraperitoneal SMV exposure exerts severe adverse effects on some serum reproductive hormones, reduction of sperm reserve and quality, apoptosis and degenerative changes of the Leydig, Sertoli and germ cells which can lead to infertility.

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Analysis of some industrial metals and ions in the cerebral cortex of goats in Nigeria

Cited by 6 publications

References 0 publications

Neuroecotoxicology: Effects of environmental heavy metal exposure on the brain of African giant rats and the contribution of vanadium to the neuropathology

Neuroecotoxicology: Effects of environmental heavy metal exposure on the brain of African giant rats and the contribution of vanadium to the neuropathology

Oxidative stress changes observed in selected organs of African giant rats (Cricetomys gambianus) exposed to sodium metavanadate

Reproductive Hormones Imbalance, Germ Cell Apoptosis, Abnormal Sperm Morphophenotypes and Ultrastructural Changes in Testis of African Giant Rats (Cricetomys gambianus, Waterhouse, 1840) Exposed to Sodium Metavanadate Intoxication

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