Analysis of survival and prognosis of 298 gastric adenocarcinoma patients with no distant metastasis

Abstract

This study investigated the survival and prognosis of 298 gastric adenocarcinoma patients with no distant metastasis. For analysis and comparison of the prognosis of patients, a retrospective analysis was performed in 298 patients with perfect clinical data and follow-up data who received the D2 resections for gastric cancer in Shandong Provincial Hospital Affiliated to Shandong University between January, 2005 and January, 2012, and were diagnosed as gastric adenocarcinoma with no distant metastasis in postoperative pathological examination. Among the gastric adenocarcinoma patients without distant metastasis, we found that differences of sex, age, differentiation and position of tumor had no statistical significance (P>0.05), while comparisons of the tumor diameter, regional lymphatic metastasis, vascular invasion and pathological TNM stages (pTNM; T for tumor, N for lymph node and M for metastasis) showed statistical significance (P<0.05). One-way analysis of variance (ANOVA) indicated the correlation between the prognosis of gastric adenocarcinoma patients and tumor diameter, regional lymphatic metastasis, vascular invasion and pTNM stages of patients (P<0.05). Multivariate analysis of Cox regression models was performed for discovering the factors associated with the prognosis of patients, and the results suggested that position of tumor (P=0.016), regional lymphatic metastasis (P=0.042), vascular invasion (P=0.021) and pTNM stage (P=0.009) were the independent risk factors affecting the prognosis of gastric adenocarcinoma patients. During 60-month follow-up, the median survival duration of gastric adenocarcinoma patients with no distant metastasis was 38 months, while the 5-year accumulate survival rate was 49.3%. The results indicated that in gastric adenocarcinoma patients without distant metastasis, tumor diameter, regional lymphatic metastasis, vascular invasion and pTNM stage are major indicators affecting the prognosis of patients.

Long-term clinicopathological prognosis on 609 cases after gastrectomy: A 10-year follow up single-institutional retrospective analysis

“…Univariate analysis showed that sex was not an independent prognostic factor of GC, which was keeping with previous studies [20][21]. We indicated that prognosis was associated with tumor size, location, type of gastrectomy and BMI.…”

“…5. Whereas multivariate analysis showed that these outcomes were not independent prognostic factors in GC, inconsistent with some studies [7,20,21]. The type of gastrectomy mainly depends on tumor location and size in clinical practice.…”

Prognostic value of RNA methylation-related genes in gastric adenocarcinoma based on bioinformatics

“…GC is the major cause of mortality from neoplastic disorders ( Wu et al, 2019 ), with gastric adenocarcinoma accounting for about 95% of stomach cancers ( Liu et al, 2017 ). As has been shown in recent decades, the development of stomach cancer is a complex process involving several components, and different molecular manifestations have variable clinical prognostic repercussions for patients.…”

<p>Construction of a nomogram for the prediction of prognosis in patients with resectable gastric cancer undergoing fewer than sixteen lymph node biopsies</p>

“…Currently, the American Joint Committee on Cancer (AJCC) pTMN is used as a basis, the 7th version of which was published in 2010 2. In patients undergoing surgery, studies have shown that both the depth of invasion (pT stage) of the primary lesions and lymph node metastases (pN stage) affect prognosis 3,4. The stage of lymph node metastasis is affected by the area of lymph node dissection, the number of examined lymph nodes (eLNs), and individual patient differences.…”