Analysis of the Action of Quaternized Chitosans with Different Molecular Weight on Anticoagulant Activity of Heparins In Vitro

Дрозд, Н. Н.; Logvinova, Yu.S.; Shagdarova, Balzhima; Ильина, А. В.; Варламов, В. П.

doi:10.1007/s10517-019-04509-w

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…This positive charge enables electrostatic interaction with anions on the surface of red blood cells, inducing robust aggregation at the wound site. This aggregation forms a blood clot promptly, effectively halting bleeding (32). Notably, chitosan is present in certain foods like chia seeds and almonds, emphasizing the significance of the degree of amino group protonation in the chitosan chain for red blood cell adsorption (33).…”

Section: Characteristics Of Chitosan Resultsmentioning

confidence: 99%

The Potential of Shell Extract as a Hemostasis and Wound Healing Agent: A Literature Review

Erlyn,

Irfannuddin,

Murti

et al. 2024

JKB

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Hemostasis is an emergency medical treatment to reduce pain and patient mortality, therefore research is being developed to find effective hemostasis. The utilization of natural materials for hemostasis and wound healing is rapidly expanding, including chitosan found in shell extracts. Chitosan is obtained from chitin found in the soft shells of marine animals such as squid, shrimp, and crabs, or from hard shells such as clams, crabs, and lobsters. Chitosan offers advantages such as good biodegradability, biocompatibility, and non-toxicity, and has been widely used in biomedical, chemical, food, and cosmetic industries. This literature review aims to investigate the potential of shell extracts, particularly the characteristics of chitosan, in wound healing across hemostasis, inflammation, proliferation, and remodeling stages. The study results indicate that extracts from shells containing chitosan exhibit varying characteristics in terms of molecular weight and degree of deacetylation. Chitosan with higher molecular weight and degree of deacetylation tends to yield better outcomes in hemostasis and wound healing. The material is effective in reducing antithrombin, enhancing blood clotting processes, and aiding clot formation. Increased molecular weight contributes to stimulating various cytokines, such as TNF-α, TGF-ß1, and FGF2, which play a key role in the wound healing process. Additionally, higher degree of deacetylation chitosan is effective in stimulating fibroblast proliferation. Chitosan also influences VEGF in inducing angiogenesis and enhancing neovascularization in bone healing. Chitosan from shell extracts with certain molecular weight characteristics and degree of deacetylation has the potential to be the material of choice for accelerating hemostasis and wound healing.

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Section: Characteristics Of Chitosan Resultsmentioning

confidence: 99%

The Potential of Shell Extract as a Hemostasis and Wound Healing Agent: A Literature Review

Erlyn,

Irfannuddin,

Murti

et al. 2024

JKB

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show abstract

“…The incorporation of the sulfate groups in the structure of chitosan improves its compatibility with blood by its complexing ability with the blood components (Heise et al, 2018). The anticoagulant activity of the chitosan and its derivatives is also greatly influenced by many factors such as degree of sulfonation (Xiong et al, 2011, Shagdarova et al, 2016, Subhapradha et al, 2013, Yang et al, 2013, Drozd et al, 2019, Song et al, 2018, Ouerghemmi et al, 2018, Drozd et al, 2017, Skorik et al, 2017, Ragab et al, 2018). Further, the N-alkylation of chitosan to primary or secondary chitosan derivatives and finally to quaternary chitosan derivatives increase the water solubility of the chitosan derivatives (Mustafa et al, 2015, Szymańska and Winnicka, 2015, Yadu et al, 2017, Cheung et al, 2015, Avadi et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…This indicated that all the synthesized derivatives had a faster onset of action and potency than nicoumalone. This may be because of the expected higher water solubility of the synthesized derivative because of the presence of sulphate group and the quaternary ammonium group (Heise et al, 2018, Shagdarova et al, 2016, Drozd et al, 2019, Song et al, 2018). However, after 3 h of drug administration the potency of compounds was less than nicoumalone.…”

Section: Discussionmentioning

confidence: 99%

“…The chitosan has a similar close structure like heparin (Heise et al, 2018). Based on this feature, many chitosan derivatives as anticoagulants have been synthesized (Vongchan et al, 2002, Vonghan et al, 2003, Vikhoreva et al, 2005, Huang et al, 2003, Xiong et al, 2011, Baumann and Faust, 2001, Shagdarova et al, 2016, Subhapradha et al, 2013, Yang et al, 2013, Drozd et al, 2019, Song et al, 2018, Ouerghemmi et al, 2018, Drozd et al, 2017, Skorik et al, 2017, Park et al, 2004, Ragab et al, 2018). Recently (Heise et al, 2018), it has been stated that incorporation of the sulfate groups in the structure of chitosan improve its compatibility with blood and increase its anticoagulation effects by its complexing ability with the blood.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, characterization and anticoagulant activity of chitosan derivatives

Imran

Sajwan

Alsuwayt

et al. 2020

Saudi Pharmaceutical Journal

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Chitosan derivatives are reported as anticoagulants in the literature. This work was undertaken to develop novel chitosan derivatives as anticoagulants. The sulfonated derivatives of chitosan were formed by the reaction of chitosan derivatives with chlorosulfonic acid in N,N-dimethylformamide. The structures of these derivatives were established by FTIR and 1H NMR spectra. The prepared derivatives were evaluated for their in vivo anticoagulant effects by the tail bleeding method in Wistar rats utilizing nicoumalone as a standard drug. The results revealed that the sulfonation of the chitosan increases its anticoagulant activity. The developed compounds exhibited faster onset of action and potency than nicoumalone after one hour of the drug administration. The sulphated N-alkyl derivatives of chitosan were more potent anticoagulants than sulfated quaternary derivatives/sulfated chitosan. It is also suggested to develop analogs of Ethyl chitosan sulfate (4b) and Benzyl chitosan sulfate (4c), which may provide some more fruitful anticoagulants having faster onset of action as well as longer duration of action and possessing a balanced hydrophilic/lipophilic character.

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“…As poly-L-lysine can be prepared by bacterial fermentation or synthetically, it may not be as vulnerable Update on the Pharmacology of Heparin and Related Drugs as protamine to supply problems. A different readily available cationic macromolecule is the polysaccharide chitin, which can be converted to quaternized chitosan with similar neutralizing effects to protamine (Drozd et al, 2019). Completely synthetic block copolymers, consisting of one neutral and one cationic block, have been made and optimized for heparin binding in vitro (V€ alim€ aki et al, 2016); the complexes so formed have a neutral outer surface and do not aggregate.…”

Section: B Neutralization Of Heparin By Protamine and Other Compoundsmentioning

confidence: 99%

Pharmacology of Heparin and Related Drugs: An Update

et al. 2023

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Analysis of the Action of Quaternized Chitosans with Different Molecular Weight on Anticoagulant Activity of Heparins In Vitro

Cited by 5 publications

References 13 publications

The Potential of Shell Extract as a Hemostasis and Wound Healing Agent: A Literature Review

The Potential of Shell Extract as a Hemostasis and Wound Healing Agent: A Literature Review

Synthesis, characterization and anticoagulant activity of chitosan derivatives

Pharmacology of Heparin and Related Drugs: An Update

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