Analysis of the associations among Helicobacter pylori infection, adiponectin, leptin, and 10-year fracture risk using the fracture risk assessment tool: A cross-sectional community-based study

Abstract

Helicobacter pylori (H. pylori) infection may induce inflammatory cytokines or adipokines that influence bone turnover and bone fracture risk. This study aimed to evaluate the association among H. pylori infection, adipokines, and 10-year fracture risk using the Fracture Risk Assessment Tool scale. From August 2013 to February 2016, a community-based cohort was surveyed by Keelung Chang-Gung Memorial Hospital. Subjects were included if they were older than 40 years and not pregnant. All participants underwent a standardized questionnaire survey, physical examination, urea breath test, and blood tests. A total of 2,689 participants (1,792 women) were included in this cross-sectional study. In both sexes, participants with a high fracture risk were older and had higher adiponectin values than participants without a high fracture risk (mean age, female: 72.9 ± 5.6 vs. 55.8 ± 7.3 years, P < 0.0001; male: 78.9 ± 4.7 vs. 58.1 ± 8.9 years, P < 0.001) (adiponectin, female: 10.8 ± 6.3 vs. 8.7 ± 5.2 ng/ml, P < 0.001; male: 9.7 ± 6.1 vs. 5.5 ± 3.8 ng/ml, P < 0.001). Adiponectin was correlated with high fracture risk in both sexes, but H. pylori infection and leptin was not. In logistic regression analysis, adiponectin could not predict high fracture risk when adjusting the factor of body mass index (BMI) in men group. In conclusion, H. pylori infection and leptin could not predict 10-year fracture risk in either sex. Adiponectin was correlated with bone fracture risk in both sexes and the correlation might be from the influence of BMI.

Role of Helicobacter pylori infection in the manifestation of old age‐related diseases

“…These factors can lead to several cardiovascular disorders and diabetes mellitus. It is a common condition affecting geriatric population (Kapil et al, ; Kapil et al, ), also leading to frailty (Lopez‐Garcia et al, ), sarcopenia (Chang et al, ), increasing the risk of fracture (Chen, Chen, Hsieh, Kuo, & Chien, ), osteoporosis (Cui et al, ), and affecting cognitive and functional abilities in this group of population (Viscogliosi, Donfrancesco, Palmieri, & Giampaoli, ). Yang and Xuan () demonstrated that H. pylori infection is associated with the increased risk of metabolic syndrome in Chinese population with the odds ratio of 5.427.…”

Correlation between Helicobacter pylori Infection and Metabolic Abnormality in General Population: A Cross-Sectional Study

“…IL-1 and TNF- α trigger bone resorption [ 9 ]. In addition, osteoporosis is a condition with progressively decreasing BMD and increased bone fragility, with increased risk of bone fractures [ 10 ]. Metabolic syndrome and osteoporosis have become worldwide public health issue, especially in elderly subjects, with huge clinical and economic burdens.…”

Assessment of Bone Metabolism and Bone Mineral Density in Children with Helicobacter pylori Infection

“…Another mechanism postulated is that impaired gastric acidification (gastric mucosal atrophy and hypo-, and achlorhydria) related to H. pylori infection might induce malabsorption of calcium and alter bone architecture (9,(13)(14)(15)(16)(17)(18) . Asaoka et al (8) reported that endoscopic gastric mucosal atrophy tended to correlate with osteoporosis and suggested that the decrease of dissolution of calcium salts caused by the decrease in gastric acid secretion in atrophic gastritis may also result in the malabsorption of calcium.…”

“…There is also reduced bone mass in osteopenia, but without involvement of microarchitecture (2,6) . While several studies reported an association between H. pylori infection and osteoporosis (8,19,20) , some of them suggested that H. pylori infection would not to be a risk factor for decreased BMD (10,18) . There are studies determining immune response and cytokines in children with gastritis (12) , but the studies evaluating association between H.pylori infection and osteoporosis in children are limited (10) .…”