Analysis of the Complete Nucleotide Sequences of Goose and Muscovy Duck Pervoviruses Indicates Common Ancestral Origin with Adeno-Associated Virus 2

Abstract

The complete nucleotide sequences of two parvoviruses isolated from goose and muscovy duck were determined. The two virus genomes share 81.9% nucleotide sequence identity, indicating that they are closely related. The coding regions are bracketed by inverted terminal repeats containing palindromes. This is similar to the genome organization of human parvoviruses, adeno-associated virus 2, and B19. Amino acid sequence comparison shows that the closest relative of the goose and muscovy duck parvoviruses is adeno-associated virus 2. This is surprising, because the goose and muscovy duck parvoviruses do not require any helper virus for productive replication, suggesting that adeno-associated virus 2 has been derived from a helper-independent ancestor.

Novel parvovirus from the worm lizard Trogonophis wiegmanni — First virus ever detected in amphisbaenian hosts

“…The phylogenetic analyses indicated the newly recognised amphisbaenian parvovirus to be unequivocally a member of the genus Dependovirus. In spite of the name referring to the dependence of most members on helper viruses, this genus also contains a couple of viruses, namely the goose and duck parvoviruses that are capable of replicating autonomously (Le Gall-Reculé and Jestin, 1994;Brown et al, 1995;Zádori et al, 1995). The other avian and mammalian parvoviruses, classified into this genus, are strictly dependent on helpers.…”

“…However, several parvoviruses, known to cause serious disease, namely the so-called Derzsy's disease in goose and Muscovy duck, are exceptions to this rule. These viruses are capable of autonomous replication in spite of their genome organisation and phylogenetic place showing them clearly to belong to the Dependovirus genus (Le Gall-Reculé and Jestin, 1994;Brown et al, 1995;Zádori et al, 1995). Nonetheless, parvoviruses in reptiles have been found with concomitant adeno-or herpesvirus infection in all cases reported previously (Heldstab and Bestetti, 1984;Ahne and Scheinert, 1989;Jacobson et al, 1996;Wozniak et al, 2000;Kim et al, 2002;Farkas and Gál, 2008).…”

Isolation of a goose parvovirus from swan and its molecular characteristics

“…GPV was first documented by Fang in 1962 and the virus causes highly contagious and fatal disease in goslings and Muscovy ducklings (Fang, 1962;Gough et al, 2005;Lu et al, 1993;Takehara et al, 1995;Zadori et al, 1995). GPV has a linear single stranded DNA genome of approximately 5,106 nt (Brown et al, 1995;Zadori et al, 1995). The genome of GPV contains two ORFs flanked by inverted terminal repeat (ITR) regions (Zadori et al, 1995).…”

“…GPV has a linear single stranded DNA genome of approximately 5,106 nt (Brown et al, 1995;Zadori et al, 1995). The genome of GPV contains two ORFs flanked by inverted terminal repeat (ITR) regions (Zadori et al, 1995). The first ORF encodes the non-structural protein (NS), and the second ORF encodes the capsid proteins VP1-3 (Zadori et al, 1995).…”

“…The genome of GPV contains two ORFs flanked by inverted terminal repeat (ITR) regions (Zadori et al, 1995). The first ORF encodes the non-structural protein (NS), and the second ORF encodes the capsid proteins VP1-3 (Zadori et al, 1995). Current GPV distribution is wide (Derzsy et al, 1970;Irvine et al, 2008;Jansson et al, 2007;Lu et al, 1993;Schettler, 1971;Sirivan et al, 1998;Takehara et al, 1995;Wan, et al, 2011;Wozniakowski et al, 2009).…”