Analysis of the equivalent dipole moment of red blood cell by using the boundary element method

Panklang, Nitipong; Techaumnat, Boonchai; Wisitsoraat, Anurat

doi:10.1016/j.enganabound.2019.12.002

Cited by 6 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…where 𝜎𝜎 and 𝑗𝑗 were the conductance and the permittivity of the medium on either side of the membrane, respectively, 𝐄𝐄 𝑛𝑛 was the normal component of the electric field, 𝑗𝑗 was the electric frequency, 𝐶𝐶 𝑚𝑚 was the specific membrane capacitance, and 𝐕𝐕 𝑚𝑚 was the transmembrane voltage. For the simulation, the intracellular permittivity 𝑗𝑗 𝑐𝑐 was 60𝑗𝑗 0 , conductivity 𝜎𝜎 𝑐𝑐 was 0.328 S/m, and 𝐶𝐶 𝑚𝑚 = 0.912 µF/cm 2 [38]. The extracellular medium was an aqueous solution with a 0.02 S/m conductivity, referred from our experimental condition.…”

Section: Numerical Simulationmentioning

confidence: 99%

On-Chip Impedance Spectroscopy of Malaria-Infected Red Blood Cells

Panklang,

Techaumnat,

Tanthanuch

et al. 2024

Sensors

Self Cite

View full text Add to dashboard Cite

Malaria is a disease that affects millions of people worldwide, particularly in developing countries. The development of accurate and efficient methods for the detection of malaria-infected cells is crucial for effective disease management and control. This paper presents the electrical impedance spectroscopy (EIS) of normal and malaria-infected red blood cells. An EIS microfluidic device, comprising a microchannel and a pair of coplanar electrodes, was fabricated for single-cell measurements in a continuous manner. Based on the EIS results, the aim of this work is to discriminate Plasmodium falciparum-infected red blood cells from the normal ones. Different from typical impedance spectroscopy, our measurement was performed for the cells in a low-conductivity medium in a frequency range between 50 kHz and 800 kHz. Numerical simulation was utilized to study the suitability parameters of the microchannel and electrodes for the EIS experiment over the measurement frequencies. The measurement results have shown that by using the low-conductivity medium, we could focus on the change in the conductance caused by the presence of a cell in the sensing electrode gap. The results indicated a distinct frequency spectrum of the conductance between the normal and infected red blood cells, which can be further used for the detection of the disease.

show abstract

Section: Numerical Simulationmentioning

confidence: 99%

On-Chip Impedance Spectroscopy of Malaria-Infected Red Blood Cells

Panklang,

Techaumnat,

Tanthanuch

et al. 2024

Sensors

Self Cite

View full text Add to dashboard Cite

show abstract

“…Considering the survival conditions of cells, the medium conductivity used in this study is 0.002 S/m. Previous studies have shown that cells can survive at this conductivity, and will not be damaged in structure or activity due to irreversible electroporation upon application of an electric field [32,41,42]. Figure A12 shows the Re[K(ω)] values of MDA-MB-231, RBC, and Granulocytes (a type of WBC) as a function of frequency for medium conductivities of 0.002 S/m.…”

Section: Frequency Response Characteristics Of Cellsmentioning

confidence: 99%

Rational Design and Numerical Analysis of a Hybrid Floating cIDE Separator for Continuous Dielectrophoretic Separation of Microparticles at High Throughput

Wang

Pesch

et al. 2022

Micromachines

View full text Add to dashboard Cite

Dielectrophoresis (DEP) enables continuous and label-free separation of (bio)microparticles with high sensitivity and selectivity, whereas the low throughput issue greatly confines its clinical application. Herein, we report a novel design of the DEP separator embedded with cylindrical interdigitated electrodes that incorporate hybrid floating electrode layout for (bio)microparticle separation at favorable throughput. To better predict microparticle trajectory in the scaled-up DEP platform, a theoretical model based on coupling of electrostatic, fluid and temperature fields is established, in which the effects of Joule heating-induced electrothermal and buoyancy flows on particles are considered. Size-based fractionation of polystyrene microspheres and dielectric properties-based isolation of MDA-MB-231 from blood cells are numerically realized, respectively, by the proposed separator with sample throughputs up to 2.6 mL/min. Notably, the induced flows can promote DEP discrimination of heterogeneous cells. This work provides a reference on tailoring design of enlarged DEP platforms for highly efficient separation of (bio)samples at high throughput.

show abstract

“…with p being the dipole moment of a cell, expressed as: p = ql q-electric charge of the dipole point charges, l-distance between the point charges; l is directly linked to the size of the cell [15].…”

Section: Introductionmentioning

confidence: 99%

“…Because of the electric charge present on a dielectric substrate’s surface, the gradient electric field dE / dx ( E –intensity of the electric field) influences the motion of the cells in the solution [ 14 ]. Therefore, the electrostatic force ( F ) that acts on the cell dipole is [ 14 ]:

with p being the dipole moment of a cell, expressed as:

q— electric charge of the dipole point charges, l— distance between the point charges; l is directly linked to the size of the cell [ 15 ]. …”

Section: Introductionmentioning

confidence: 99%

“…In fact, since Sc cells are ellipsoid-like in shaped [ 16 ], the value of their dipole moment is directly influenced by their dimensions [ 15 ]. Therefore, if the goal is to attach the highest possible number of cells to the substrate surface and since the Sc cell dimensions vary among their population [ 17 ], the electric field at the substrate surface must be statistically distributed over it.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Correlation of Statistical Distributions of the Dimension of Yeast Cells Attached to the Substrate and Its Surface Electrical Potential

et al. 2021

View full text Add to dashboard Cite

The ability of cells to adhere to substrates is an important factor for the effectiveness of biotechnologies and bioimplants. This research demonstrates that the statistical distribution of the sizes of the cells (Saccharomyces cerevisiae) attached to the substrate surface correlates with the statistical distribution of electrical potential on the substrate’s surface. Hypothetically, this behavior should be taken into consideration during the processing of surfaces when cell adhesion based on cell size is required.

show abstract

Analysis of the equivalent dipole moment of red blood cell by using the boundary element method

Cited by 6 publications

References 22 publications

On-Chip Impedance Spectroscopy of Malaria-Infected Red Blood Cells

On-Chip Impedance Spectroscopy of Malaria-Infected Red Blood Cells

Rational Design and Numerical Analysis of a Hybrid Floating cIDE Separator for Continuous Dielectrophoretic Separation of Microparticles at High Throughput

Correlation of Statistical Distributions of the Dimension of Yeast Cells Attached to the Substrate and Its Surface Electrical Potential

Contact Info

Product

Resources

About