The surface uplift history of the Tibetan Plateau and Himalaya is among the most interesting topics in geosciences because of its effect on regional and global climate during Cenozoic time, its influence on monsoon intensity, and its reflection of the dynamics of continental plateaus. Models of plateau growth vary in time, from pre-India-Asia collision (e.g., Ϸ100 Ma ago) to gradual uplift after the India-Asia collision (e.g., Ϸ55 Ma ago) and to more recent abrupt uplift (<7 Ma ago), and vary in space, from northward stepwise growth of topography to simultaneous surface uplift across the plateau. Here, we improve that understanding by presenting geologic and geophysical data from north-central Tibet, including magnetostratigraphy, sedimentology, paleocurrent measurements, and 40 Ar/ 39 Ar and fission-track studies, to show that the central plateau was elevated by 40 Ma ago. Regions south and north of the central plateau gained elevation significantly later. During Eocene time, the northern boundary of the protoplateau was in the region of the Tanggula Shan. Elevation gain started in pre-Eocene time in the Lhasa and Qiangtang terranes and expanded throughout the Neogene toward its present southern and northern margins in the Himalaya and Qilian Shan.climate ͉ tectonics ͉ magnetostratigraphy ͉ Hoh Xil Basin ͉ Cenozoic T he Tibetan Plateau is the most extensive region of elevated topography in the world (Fig. 1). How such high topography, which should have an effect on climate, monsoon intensity, and ocean chemistry (1-5), has developed through geologic time remains disputed. Various lines of investigation, including evidence from the initiation of rift basins (6), potassium-rich (K-rich) volcanism (7), tectonogeomorphic studies of fluvial systems and drainage basins (8), thermochronologic studies (9), upper-crustal deformation histories (10, 11), stratigraphic and magnetostratigraphic studies of sediment accumulation rates (12), paleobotany (13), and oxygen isotope-based paleoaltimetry (14-22), have suggested different uplift histories. Authors of recent geologic studies (11) have proposed that significant crustal thickening (and by inference, surface uplift) in the Qiangtang terrane occurred in the Early Cretaceous [Ϸ145 mega-annum (Ma) age], followed by major crustal thickening within the Lhasa terrane between Ϸ100 and 50 Ma ago. This hypothesis remains disputed (23). Other models of plateau growth range from Oligocene (e.g., Ϸ30 Ma ago) gradual surface uplift (7) to more recent (Ͻ7 Ma ago) and abrupt surface uplift (24), with oblique stepwise growth of elevation northward and eastward after the India-Eurasia collision (7,20,25,26). With few exceptions (e.g., see refs. 11 and 27), most of these models focus on data from the Himalaya and southern Tibet and remain relatively unconstrained by geologic data from the interior of the Tibetan Plateau.The Hoh Xil Basin (HXB) of the north-central Tibetan Plateau (Figs. 1 and 2) is the most widespread exposure of Paleogene sediments on the high plateau and contains Ͼ5,000...