Analysis of the Inflammatory Network in Benign Prostate Hyperplasia and Prostate Cancer

König, J; Senge, Theodor; Allhoff, E.P.; König, W

doi:10.1016/s0022-5347(05)00607-5

Cited by 26 publications

(35 citation statements)

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“…Partin et al 7 have demonstrated that doxazosin treatment resulted in caspase-3 activation within 24 h. Caspase-3 is a crucial enzyme for the executive phase of apoptosis that can be activated after the stimulation of tumor necrosis factor family receptors. Konig et al 26,27 have demonstrated that TNF-a can be one of the key factors in the benign prostate hyperplasia (BPH) pathogenesis. TNF-a induces cell death and cell proliferation within prostate tissues.…”

Section: Discussionmentioning

confidence: 99%

The influence of α1-antagonist on the expression pattern of TNF receptor family in primary culture of prostate epithelial cells from BPH patients

Drewa

Wolski

Misterek

et al. 2007

Prostate Cancer Prostatic Dis

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Doxazosin triggers apoptosis via an imprecisely defined receptor mechanism that is related to tumor necrosis factor receptors (TNFRs). The aim of this study was to determine CD95, TNFR-1, TNFR-2, CD40 expression in primary prostate epithelial cultures incubated with doxazosin. Epithelial cultures were cultivated from 10 benign prostate hyperplasia patients. The cells were incubated with 20, 50 and 80 lM of doxazosin. Apoptosis was confirmed by fluorescence microscopy and flow cytometry. The cells were analyzed for expression of FAS, CD40, TNFR-1 and TNFR-2 by flow cytometry. Early apoptotic cells were present in all groups. A positive correlation was noticed between doxazosin dose and TNFR-1-, -2-positive cells. A decrease of CD40-positive cell population was observed in the lowest concentration. A decrease of mean fluorescence intensity signal of CD40 and CD95 was observed in the lowest concentration. Doxazosin-triggered apoptosis was doseindependent. The initiation of apoptosis was a result of receptors 'crosstalk' rather than a single receptor pathway activation. TNF receptor self-assembly process should be checked as a potential mechanism leading to apoptosis after doxazosin treatment.

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Section: Discussionmentioning

confidence: 99%

The influence of α1-antagonist on the expression pattern of TNF receptor family in primary culture of prostate epithelial cells from BPH patients

Drewa

Wolski

Misterek

et al. 2007

Prostate Cancer Prostatic Dis

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“…There is a clear correlation between age and incidence of prostatic calculi, although the presence of prostatic calculi in younger men is often associated with symptoms of inflammation and prostatitis [7]. Konig et al [8] reported that prostatic calculi induce prostatitis, which produces and aggravates LUTS. Prostatitis produces LUTS by contraction of the smooth muscle of the prostate and bladder neck.…”

Section: Introductionmentioning

confidence: 99%

Are prostatic calculi independent predictive factors of lower urinary tract symptoms?

Park¹,

Nam²,

Lee³

et al. 2009

Asian J Androl

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We determined the correlation between prostatic calculi and lower urinary tract symptoms (LUTS), as well as the predisposing factors of prostatic calculi. Of the 1 527 patients who presented at our clinic for LUTS, 802 underwent complete evaluations, including transrectal ultrasonography, voided bladder-3 specimen and international prostatic symptoms score (IPSS). A total of 335 patients with prostatic calculi and 467 patients without prostatic calculi were divided into calculi and no calculi groups, respectively. Predictive factors of severe LUTS and prostatic calculi were determined using uni/multivariate analysis. The overall IPSS score was 15.7 ± 9.2 and 14.1 ± 9.1 in the calculi and no calculi group, respectively (P = 0.013). The maximum flow rate was 12.1 ± 6.9 and 14.2 ± 8.2 mL s −1 in the calculi and no calculi group, respectively (P = 0.003). On univariate analysis for predicting factors of severe LUTS, differences on age (P = 0.042), prostatic calculi (P = 0.048) and prostatitis (P = 0.018) were statistically significant. However, on multivariate analysis, no factor was significant. On multivariate analysis for predisposing factors of prostatic calculi, differences on age (P < 0.001) and prostate volume (P = 0.001) were significant. To our knowledge, patients who have prostatic calculi complain of more severe LUTS. However, prostatic calculi are not an independent predictive factor of severe LUTS. Therefore, men with prostatic calculi have more severe LUTS not only because of prostatic calculi but also because of age and other factors. In addition, old age and large prostate volume are independent predisposing factors for prostatic calculi.

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“…Studies by Phipps et al 2 have demonstrated fundamental morphological differences between BPH and PCa. Using reverse transcription-PCR to investigate inflammatory and cell biological cascades, Konig et al 3 found distinct differences in gene expression between prostate tissue obtained from patients with BPH vs PCa. However, they concluded that inflammation appeared to be involved in the development of both prostate problems.…”

Section: Introductionmentioning

confidence: 99%

Effect of diet and exercise intervention on the growth of prostate epithelial cells

Barnard

Kobayashi

Aronson

2008

Prostate Cancer Prostatic Dis

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Epidemiological studies suggest a positive association between nutrient intake, hyperinsulinemia and risk of Benign prostatic hyperplasis (BPH). This study tests the hypothesis that a low-fat, highfiber diet and daily exercise would lower serum insulin and reduce the growth of serum-stimulated primary prostate epithelial cells in culture. Serum samples were obtained from eight overweight men before and after the Pritikin residential, 2-week diet and exercise intervention and from seven men who were long-term followers of the low-fat, high-fiber diet and regular exercise lifestyle. The serum was used to stimulate primary prostate epithelial cells in culture. Growth was measured after 48 and 96 h and apoptosis after 96 h. At 48 h there was no significant difference in growth within the Pre, 2-week or Long-Term groups. At 96 h growth was significantly reduced in the 2-week (13%) and in the Long-Term (14%) groups compared to the Pre data. At 96 h, apoptosis was not significantly different among the three groups. Fasting insulin was reduced by 30% in the 2-week group and by 52% in the Long-Term group compared to the Pre data. Testosterone was unchanged in the 2-week group. The results of this study indicate that a low-fat, high-fiber diet and daily exercise lowers insulin and reduces growth of prostate primary epithelial cells and suggests that lifestyle may be an important factor in the development or progression of BPH. Future prospective trials should address the effects of this lifestyle modification on BPH symptomatology and progression.

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Analysis of the Inflammatory Network in Benign Prostate Hyperplasia and Prostate Cancer

Cited by 26 publications

References 0 publications

The influence of α1-antagonist on the expression pattern of TNF receptor family in primary culture of prostate epithelial cells from BPH patients

The influence of α1-antagonist on the expression pattern of TNF receptor family in primary culture of prostate epithelial cells from BPH patients

Are prostatic calculi independent predictive factors of lower urinary tract symptoms?

Effect of diet and exercise intervention on the growth of prostate epithelial cells

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