Analysis of the Influenza A (H1N1) 2009 Pandemic Infection in Japanese Asthmatic Patients: Using a Questionnaire-Based Survey

Koshio, Nao; Hasegawa, Takashi; Suzuki, Kazuo; Tanabe, Yoshinari; Koya, Toshiyuki; Sakagami, Takuro; Aoki, Nobumasa; Hoshino, Yoshifumi; Kagamu, Hiroshi; Tsukada, Hiroki; Arakawa, Masaaki; Gejyo, Fumitake; Narita, Ichiei; Suzuki, Eiichi

doi:10.2332/allergolint.13-oa-0609

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…Only 1 study focused on adults with asthma . In this study, the H1N1 influenza vaccine was found to be protective against influenza in those aged under 61 years, but not in older patients.…”

Section: Effectiveness Of Influenza Vaccination In Asthmamentioning

confidence: 74%

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Influenza burden, prevention, and treatment in asthma‐A scoping review by the EAACI Influenza in asthma task force

Schwarze

Openshaw

Jha

et al. 2018

Allergy

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To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness, and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma. The strongest evidence of an association was seen in studies of children. Countries in the European Union currently recommend influenza vaccination of adults with asthma; however, coverage varied between regions. Coverage was lower among children with asthma. Limited data suggest that good seroprotection and seroconversion can be achieved in both children and adults with asthma and that vaccination confers a degree of protection against influenza illness and asthma-related morbidity to children with asthma. There were insufficient data to determine efficacy in adults. Overall, influenza vaccines appeared to be safe for people with asthma. We identify knowledge gaps and make recommendations on future research needs in relation to influenza in patients with asthma.

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Section: Effectiveness Of Influenza Vaccination In Asthmamentioning

confidence: 74%

“…There are limited data on the effectiveness of influenza vaccination in patients with asthma or high‐risk populations that included asthma. Six studies assessed the effectiveness of seasonal influenza vaccines, while 1 other studied the H1N1 pandemic vaccine …”

Section: Effectiveness Of Influenza Vaccination In Asthmamentioning

confidence: 99%

Influenza burden, prevention, and treatment in asthma‐A scoping review by the EAACI Influenza in asthma task force

Schwarze

Openshaw

Jha

et al. 2018

Allergy

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“…Patients that were not on long-term therapeutics to control asthma symptoms had a higher incidence of pH1N1 infection ( 120 , 121 , 134 , 135 ). While the pH1N1 virus did increase the number of asthma exacerbations compared to seasonal strains ( 126 ), virus infection did not correlate to the severity of asthma symptoms ( 126 ). Higher rates of infection and hospitalization of children also corresponded with higher rates of admission to pediatric intensive care units (PICU) during the 2009 influenza pandemic.…”

Section: Asthma and The 2009 Swine Flu Pandemicmentioning

confidence: 98%

“…Specific diagnosis for asthma requires common allergen testing, serum IgE testing, successfully executed spirometry at baseline and often after exercise, symptom reversal after treatment with short acting beta agonists ( 40 , 45 ) etc., that require a specialist. As such, data that relied on self-reporting or clinician’s notes at triage must be carefully interpreted ( 124 – 126 ) as wheezing non-asthmatics may have been categorized incorrectly as asthmatics. Although environmental pollutants are known to complicate asthma ( 127 ) and influenza ( 128 ), information on tobacco smoke exposure was only provided in a small number of these reports (Figure 4 ).…”

Section: Asthma and The 2009 Swine Flu Pandemicmentioning

confidence: 99%

Influenza in Asthmatics: For Better or for Worse?

2018

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Asthma and influenza are two pathologic conditions of the respiratory tract that affect millions worldwide. Influenza virus of the 2009 pandemic was highly transmissible and caused severe respiratory disease in young and middle-aged individuals. Asthma was discovered to be an underlying co-morbidity that led to hospitalizations during this influenza pandemic albeit with less severe outcomes. However, animal studies that investigated the relationship between allergic inflammation and pandemic (p)H1N1 infection, showed that while characteristics of allergic airways disease were exacerbated by this virus, governing immune responses that cause exacerbations may actually protect the host from severe outcomes associated with influenza. To better understand the relationship between asthma and severe influenza during the last pandemic, we conducted a systematic literature review of reports on hospitalized patients with asthma as a co-morbid condition during the pH1N1 season. Herein, we report that numerous other underlying conditions, such as cardiovascular, neurologic, and metabolic diseases may have been underplayed as major drivers of severe influenza during the 2009 pandemic. This review synopses, (1) asthma and influenza independently, (2) epidemiologic data surrounding asthma during the 2009 influenza pandemic, and (3) recent advances in our understanding of allergic host–pathogen interactions in the context of allergic airways disease and influenza in mouse models. Our goal is to showcase possible immunological benefits of allergic airways inflammation as countermeasures for influenza virus infections as a learning tool to discover novel pathways that can enhance our ability to hinder influenza virus replication and host pathology induced thereof.

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Asthma and influenza vaccination in elderly hospitalized patients: Matched case-control study in Spain

Suárez-Varela¹,

Llopis²,

Fernández-Fabrellas

et al. 2017

Journal of Asthma

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Analysis of the Influenza A (H1N1) 2009 Pandemic Infection in Japanese Asthmatic Patients: Using a Questionnaire-Based Survey

Abstract: The effectiveness of the vaccination against the H1N1 pdm09 virus was confirmed during the first pandemic season, but it was limited. Further investigation on H1N1 pdm09 virus infection in asthmatics will be required.

Cited by 3 publications

References 22 publications

Influenza burden, prevention, and treatment in asthma‐A scoping review by the EAACI Influenza in asthma task force

Influenza burden, prevention, and treatment in asthma‐A scoping review by the EAACI Influenza in asthma task force

Influenza in Asthmatics: For Better or for Worse?

Asthma and influenza vaccination in elderly hospitalized patients: Matched case-control study in Spain

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