Nowadays, predicting students' performance is one of the most specific topics for learning environments, such as universities and schools, since it leads to the development of effective mechanisms that can enhance academic outcomes and avoid destruction. In education 4.0, Artificial Intelligence (AI) can play a key role in identifying new factors in students' performance and implementing personalized learning, answering routine student questions, using learning analytics, and predictive modeling. It is a new challenge to redefine education 4.0 to recognize the creative and innovative intelligent students, and it is difficult to determine students' outcomes. Hence, in this paper, Hybridized Deep Neural Network (HDNN) to predict student performance in Education 4.0. The proposed HDNN method is utilized to determine the dynamics that likely influence the student's performance. The deep neural network monitors predict, and evaluate students' performance in an education 4.0 environment. The findings show that the proposed HDNN method achieved better prediction accuracy when compared to other popular methods.