A simple radial basis function (RBF) meshless method is used to solve the two-dimensional shallow water equations (SWEs) for simulation of dam break flows over irregular, frictional topography involving wetting and drying. At first, we construct the RBF interpolation corresponding to space derivative operators. Next, we obtain numerical schemes to solve the SWEs, by using the gradient of the interpolant to approximate the spatial derivative of the differential equation and a third-order explicit Runge-Kutta scheme to approximate the temporal derivative of the differential equation. For the problems involving shock or discontinuity solutions, we use an artificial viscosity for shock capturing. en, we apply our scheme for several theoretical twodimensional numerical experiments involving dam break flows over nonuniform beds and moving wet-dry fronts over irregular bed topography. Promising results are obtained.